B-Cell Lymphoma of Bronchus-Associated Lymphoid Tissue (BALT): CT Features in 10 Patients

“…Computed tomography (CT) (figs. 1b and c), which is more sensitive than standard radiography, has demonstrated that the lesions are usually bilateral (60-70%) and multiple (70-77%) [25,26]. Nearly all these lesions contain clear areas corresponding to an intact bronchial lumen ( fig.…”

Section: Mucosa-associated Lymphoid Tissue Lymphomamentioning

confidence: 96%

Primary pulmonary lymphoma

Cadranel¹,

Wislez²,

Antoine³

2002

European Respiratory Journal

332

345

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Three distinct entities are now covered by the definition of primary pulmonary clonal lymphoid proliferation. The aim of this review is to describe the pathophysiological, diagnostic, prognostic and therapeutic aspects of these three entities.Low-grade pulmonary B-cell lymphoma is the most frequent form of primary pulmonary clonal lymphoid proliferation. It arises from mucosa-associated lymphoid tissue. It is usually indolent and appears in the form of a chronic alveolar opacity. The prognosis is excellent, but treatment is controversial (simple monitoring, surgery or single-agent chemotherapy). High-grade pulmonary B-cell lymphoma is far rarer and usually occurs in individuals with an underlying disorder (e.g. immunodeficiency). The prognosis is poor and therapeutic options depend on the underlying disorder.The inclusion of lymphomatoid granulomatosis in the definition of primary pulmonary lymphomas is controversial. The clonal nature of the proliferation is very rarely demonstrated and extrapulmonary involvement is frequent (upper airways, skin, kidneys, central nervous system, etc.). The prognosis is extremely variable, with some authors reporting complete remission with steroids and cyclophosphamide and others reporting failure of combination chemotherapy. Eur Respir J 2002; 20: 750-762.

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“…[11,13,14]. Bae and coworkers classified the findings of chest CT in BALToma into four patterns, namely solitary nodule with consolidation, multiple nodular lesion with consolidation, bronchiolitis with bronchiectasis, and diffuse interstitial pneumonia [15]. It is difficult to arrive at a diagnosis of MALToma from an infiltrated lesion with manifest bronchiectasis of one entire lobe like the right lower lobe in the present case by recalling conventional chest imaging patterns of MALToma.…”

Section: Discussionmentioning

confidence: 88%

A Case of Mucosa-Associated Lymphoid Tissue Lymphoma (MALToma) That Developed From Lungs and Stomach

Ono¹

2011

J Med Cases

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The case concerns a 52-year-old male who presented at our hospital because of abnormal chest X-ray findings following a group medical examination. On the computed tomography (CT) image, there was an infiltrative shadow with bronchiectasis manifest in the right lower lobe, a right pleural effusion (PE), densities on bronchovascular bundles elsewhere in the lungs and clear thickening of the gastric wall. In the PE, we detected cells reminiscent morphologically of malignant lymphoma and with a chromosomal abnormality, and a gene rearrangement of the B-cell. By trans-bronchial brushing, we detected cells that were similar to those in the PE in the right lower lobe, and the findings of transbronchial lung biopsies (TBLB) and gastric biopsies were both compatible with mucosa-associated lymphoid tissue lymphoma (MALToma). Thus, we diagnosed this as a case of MALToma which developed from the lungs and the stomach, and suggest that MALToma should be considered in the differential diagnosis of lung disease.

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B-Cell Lymphoma of Bronchus-Associated Lymphoid Tissue (BALT): CT Features in 10 Patients

Cited by 82 publications

References 23 publications

The radiological spectrum of pulmonary lymphoproliferative disease

The radiological spectrum of pulmonary lymphoproliferative disease

Primary pulmonary lymphoma

A Case of Mucosa-Associated Lymphoid Tissue Lymphoma (MALToma) That Developed From Lungs and Stomach

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