"B.C.G. Sarcoidosis"

Ellman, Philip; Andrews, Leslie G.

doi:10.1136/bmj.1.5135.1433

Cited by 13 publications

(3 citation statements)

References 10 publications

(3 reference statements)

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“…The value for tryptophan was calculated by the method of Bencze & Schmid (1957). Titration with dithionitrobenzoic acid in 8M-urea (Ellman, 1959) indicates the presence of two reducing thiol groups per subunit of mol.wt. 40000.…”

Section: Resultsmentioning

confidence: 99%

Purification of yeast isocitrate dehydrogenase

Illingworth

1972

Biochemical Journal

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The NAD-linked isocitrate dehydrogenase from baker's yeast was purified to homogeneity (as judged by gel filtration and polyacrylamide-gel electrophoresis) with an overall yield of 50% by using dilute solutions of the allosteric effector (AMP) to elute the enzyme specifically from CM-cellulose. This method preserves the allosteric properties of the crude enzyme. Although the pure enzyme shows only a single band on electrophoresis in the presence of sodium dodecyl sulphate, two types of subunit are observed in 8m-urea. The isoelectric point of the enzyme rises during purification, and this may reflect the partial loss of an additional low-molecular-weight component. Values are included for the amino acid composition and extinction coefficients of the pure enzyme.

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Section: Resultsmentioning

confidence: 99%

Purification of yeast isocitrate dehydrogenase

Illingworth

1972

Biochemical Journal

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“…Old literatures suggested that BCG (Bacillus Calmette-Guerin) vaccination would be linked to the onset of sarcoidosis. 38 More recently, juvenile sarcoidosis, which is now designated as Blau syndrome in the entity of autoinflammatory diseases, 39 has been reported to develop after BCG vaccination. 40,41 In the light of the present case with presumed COVID-19 mRNA vaccine–associated sarcoidosis, immunological perturbation as a result of vaccination might underlay the onset of sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 mRNA Vaccine–Associated Uveitis Leading to Diagnosis of Sarcoidosis: Case Report and Review of Literature

Matsuo

Honda

Tanaka

et al. 2022

Journal of Investigative Medicine High Impact Case Reports

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A 34-year-old Japanese person with male gender identity who had been taking intramuscular injection of methyltestosterone depot for 11 years after bilateral mastectomy noticed blurred vision 5 days after the second vaccination for COVID-19 (Tozinameran; Pfizer-BioNTech) in the interval of 3 weeks following the first vaccination. The patient was diagnosed as granulomatous iritis with mutton-fat keratic precipitates and small iris nodules at the pupillary margin in the right eye and began to have 0.1% betamethasone eye drops with good response. The patient, however, continued to have fever and malaise and showed a high level of serum soluble interleukin-2 receptor (sIL-2R) even 4 weeks after the second vaccination. Computed tomographic scan disclosed mediastinal and bilateral hilar small lymphadenopathy together with limited granular lesion in the right lung. Gallium-67 scintigraphy demonstrated high uptake not only in mediastinal and hilar lymph nodes but also in bilateral parotid glands. Right parotid gland biopsy revealed noncaseating granulomas and proved pathological diagnosis of sarcoidosis. The systemic symptoms were relieved by oral prednisolone 20 mg daily. Even though the causal relationship remains undetermined, this case is unique at the point that vaccine-associated uveitis led to the detection of pulmonary lesions and lymphadenopathy, resulting in clinical and pathological diagnosis of sarcoidosis. In literature review, 3 patients showed sarcoidosis-like diseases after COVID-19 vaccination: 2 patients were diagnosed clinically as Lofgren syndrome with acute onset of erythema nodosum and ankle swelling, with or without mediastinal and hilar lymphadenopathy, whereas 1 patient with mediastinal lymphadenopathy but no uveitis was diagnosed pathologically by biopsy as sarcoidosis.

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“…vaccination reported include regional adenitis with or without caseation (cold abscess formation), lupus vulgaris, subcutaneous cold abscesses, scrofuloderma, lymphadenitis, tuberculid and tuberculosis verrucosa cutis at the site of the injection, ocular lesions (including phlyctenular conjunctivitis), and "lighting up" of underlying tuberculous infection, all of which are very uncommon (M. R.C., 1956;Horwitz and Meyer, 1957;Anderson et al, 1959). Provocation of sarcoidosis (Ellman and Andrews, 1959) may possibly also be a complication of B.C.G. vaccination.…”

mentioning

confidence: 99%

Unusual complication of B.C.G. vaccination.

Watkins¹

1971

BMJ

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"B.C.G. Sarcoidosis"

Cited by 13 publications

References 10 publications

Purification of yeast isocitrate dehydrogenase

Purification of yeast isocitrate dehydrogenase

COVID-19 mRNA Vaccine–Associated Uveitis Leading to Diagnosis of Sarcoidosis: Case Report and Review of Literature

Unusual complication of B.C.G. vaccination.

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