Unusual complication of B.C.G. vaccination.

Immunotherapy of Cancer with Nonliving BCG and Fractions Derived from Mycobacteria: Role of Cord Factor (Trehalose-6, 6′-Dimycolate) in Tumor Regression

“…However, living BCG can cause disseminated disease in an immunosuppressed host (10,14,18,19,29). Although local reactions at the site of injections may be severe, they generally disappear (16,31). Seventeen deaths from generalized infection with BCG have been reported also during large scale vaccination (10,18,29).…”

Juvenile Melanoma after BCG Vaccination

“…Keloid, epithelial cysts and granuloma have been described [Watkins, 1971] and recently a basal cell epithelioma [Nielsen, 1979], Lokich [1975] re ported the development of a malignant melanoma 4 weeks after a BCG scarification in a patient with multiple melanomas. In this last case, however, no inflammatory cells were observed, although skin test with BCG showed the same positive responses as the pretherapy tests.…”

Allergic contact sensitivity to BCG

“…The BCG was administered by scarification at 4 different sites (upper arms and thighs) at weekly intervals. Each scarification was made with one vial (6X 10 8 viable organisms) oflyophilized BCG Pasteur F. Extensive contact dermatitis was observed in 2 patients after the 6th inoculation, in another 2 patients after the lOth inoculation, and in 2 patients after the 19th and 24th inoculations (6)(7)(8)(9)(10)(11). The rash developed simultaneously at a114 sites.…”