B-1 B Cell Subset Composition of DBA/2J Mice

Howell, Koko; Campo, Melissa; Chiasson, Roderick; Duffy, Kevin T.; Riggs, James E.

doi:10.1078/0171-2985-00133

Cited by 3 publications

(5 citation statements)

References 35 publications

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“…Neither of these studies monitored CD11b expression on B‐cell subsets. Recent research indicates that this marker is definitive for the B‐1 cells found in certain strains of mice 27,28 . To ensure a complete analysis of B‐cell subset composition, future studies will need to include CD11b in the growing panel of reagents employed to define these cells 17 .…”

Section: Discussionmentioning

confidence: 99%

“…Recent research indicates that this marker is de®nitive for the B-1 cells found in certain strains of mice. 27,28 To ensure a complete analysis of B-cell subset composition, future studies will need to include CD11b in the growing panel of reagents employed to de®ne these cells. 17 Consistent with prior studies, XID PerC B-1 cells were found to express the leukosialin-speci®c marker CD43 and the tetraspanin-speci®c marker CD9 24,30,40 (data not shown).…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have shown that CD11b expression best defines B‐1 B cells in several strains of mice 27,28 . As B‐1 B cells are essential for innate immunity, we felt that the B‐1 B‐cell phenotype of XID mice should be revisited using this marker 19–21 .…”

Section: Introductionmentioning

confidence: 99%

“…7,9,10,15±18 Recent studies have shown that CD11b expression best de®nes B-1 B cells in several strains of mice. 27,28 As B-1 B cells are essential for innate immunity, we felt that the B-1 Bcell phenotype of XID mice should be revisited using this marker. 19±21 In this report we show that B-1b cells are present in XID mice; B-1a cells, when present, are found at a lower frequency.…”

Section: Introductionmentioning

confidence: 99%

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X‐chromosome‐linked immune‐deficient mice have B‐1b cells

et al. 2003

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SUMMARYThe B lymphocyte subsets of X-chromosome-linked immune-de®cient (XID) mice were examined by¯ow cytometric analyses of spleen and peritoneal cells. As shown in prior studies, young adult XID mice had reduced representation of the CD5 (B-1a) subset in their peritoneal cavity. However, the CD11b (B-1b) B-cell subset was present and exhibited the IgM hi CD45 lo CD23À phenotype characteristic of most B-1 cells. Although present at a lower frequency than that found in their normal counterparts, B-1b cells were evident in CBA/N and (XD2J)F 1 male mice. With increasing age, B-1b cell number increased and in the oldest XID mice were present as B-cell chronic lymphocytic leukaemia. These results show that XID mice do have B-1 cells, particularly the B-1b subset.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

X‐chromosome‐linked immune‐deficient mice have B‐1b cells

et al. 2003

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“…The loss of B cells and mast cells may be a consequence of the secondary necrosis of apoptotic macrophages that may occur in the absence of a population of viable macrophages to phagocytose the dying cells. Also, a subset of B lymphocytes and mast cells may express CD11b and this may account for the reduced numbers seen after the administration of DT (30)(31)(32).…”

Section: Transgenic Pleural Resident Mφ Are Ablated By Dt In Vivomentioning

confidence: 99%