Aβ-fiber nociceptive primary afferent neurons: a review of incidence and properties in relation to other afferent A-fiber neurons in mammals

Djouhri, Laiche; Lawson, Sally N.

doi:10.1016/j.brainresrev.2004.07.015

Cited by 321 publications

(289 citation statements)

References 64 publications

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“…C3 expresses Th, Fam19a4, Cpne6 and Piezo2 [50]. Our finding indicates that C9 neurons are Aβ-MNs, consistent with the early idea regarding Aβ-fiber nociceptive DRG neurons [51]. C8 neurons differentially express Trpc1, Kcnk4, Asic3 and Piezo2, suggesting their roles in mechanoreception.…”

Section: Functional Annotations Of Neuron Types and Related Gene-netwsupporting

confidence: 88%

Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity

et al. 2015

Cell Res

398

432

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Section: Functional Annotations Of Neuron Types and Related Gene-netwsupporting

confidence: 88%

Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity

et al. 2015

Cell Res

398

432

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“…According to the international literature A␦-, compared to A␤-fibers, primarily mediate nociceptive responses. However, up to 60% of the nociceptive responses in rats (and other species) are reported to be mediated by A␤-fibers, which is generally neglected [11]. Therefore, conduction velocities alone cannot definitively distinguish between responses representing nociceptive or tactile sensations.…”

Section: Discussionmentioning

confidence: 99%

Somatosensory-evoked potentials indicate increased unpleasantness of noxious stimuli in response to increasing stimulus intensities in the rat

Oostrom

Stienen

Bos

et al. 2007

Brain Research Bulletin

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Recently, it has been shown in rats that specific characteristics of somatosensory-evoked potentials (SEPs) recorded from different sites on the scalp correlate differently to the amount of unpleasantness experienced by the animal following noxious stimulation. It was shown that the SEP recorded from vertex (Vx-SEP) did correlate with the unpleasantness, whereas the SEP recorded from the primary somatosensory cortex (SI-SEP) did not. In the present study, we further investigated the relationship between the Vx-SEP, SI-SEP and the unpleasantness of noxious stimuli. Therefore, different groups of rats were subjected to a SEP fear-conditioning paradigm in which the unconditioned stimulus (US), represented by noxious stimuli applied to evoke SEPs, was paired to a conditioned stimulus (CS) represented by a tone. Different stimulus intensities of the US were applied in the different groups. After CS-US presentation, CS-induced fear-conditioned behaviour was analysed in relation to the characteristics of the Vx-and SI-SEP during CS-US presentation. Results showed that increasing stimulus intensities led to increased SEP amplitudes, which were paralleled by an increased amount of CS-induced fear-conditioned behaviour. No differences between Vx-SEP and SI-SEP were found. The increase in the SEPs in parallel with the increased amount of fear-induced behaviour further supports the SEP to be a potentially valuable tool for studying acute pain and analgesia in animals.

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“…Moreover, many nociceptive neurones will respond to more than one 313 type of stimulus. C and the three A fibre nociceptor subtypes all respond to 314 mechanical stimuli, so the stimulus used in this study should have been appropriate 315 to differentiate our study groups (Djouhri and Lawson 2004). 316…”

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confidence: 99%

Mechanical nociceptive threshold testing in Bos indicus bull calves

et al. 2017

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Pain assessment in cattle is difficult, but is essential to assess the effect of surgery 13 and analgesic drugs. Nociceptive threshold testing is an objective pain assessment 14 tool that has not been described in Bos indicus cattle. A technique for mechanical 15 nociceptive threshold testing was developed for use in Bos indicus cattle undergoing 16 surgical castration to evaluate post-operative pain. 17 Abstract. 18The aim of this prospective, controlled, randomised trial was to develop a technique 19 for mechanical nociceptive threshold testing ( and on days 1, 2, 6, 10 and 13 after surgery. A handheld manual pneumatic device 27 with a 1 mm (diameter) blunt pin was used to deliver a mechanical stimulus to a 28 maximum of 27 Newtons (N) either side of the most dorsal aspect of the sacrum. 29The most frequent responses to the mechanical stimulus were lifting or kicking of 30 the leg on the same side as the stimulus (31%) and stepping away from the stimulus 31 (24.9 %). Data were analysed with a mixed effect linear model with the nociceptive 32 threshold (NT) as the response variable and day and analgesic treatment as 33 predictors (p < 0.05 was considered significant). For all groups, there was a trend 34 toward decreasing NT over the study period but there were no significant 35 differences between groups.Step down model selection with day, batch and 36 treatment terms revealed a significant effect of day (p < 0.001) and batch (p = 37 0.007). Mechanical NTT for assessment of pain in Bos indicus bull calves requires 38 further refinement to determine if this is a useful method of pain assessment. 39

show abstract

Aβ-fiber nociceptive primary afferent neurons: a review of incidence and properties in relation to other afferent A-fiber neurons in mammals

Cited by 321 publications

References 64 publications

Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity

Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity

Somatosensory-evoked potentials indicate increased unpleasantness of noxious stimuli in response to increasing stimulus intensities in the rat

Mechanical nociceptive threshold testing in Bos indicus bull calves

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