Azoospermia after treatment with clomiphene citrate in patients with oligospermia

Pasqualotto, Fábio Firmbach; Fonseca, Gabriela Poglia; Pasqualotto, Eleonora Bedin

doi:10.1016/j.fertnstert.2008.03.036

Cited by 44 publications

(37 citation statements)

References 2 publications

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“…Clomiphene citrate was not used in these patients because there were published data suggesting development of azoospermia after treatment with clomiphene citrate in patients having oligospermia (16).…”

Section: Discussionmentioning

confidence: 99%

Changes in hormonal profile and seminal parameters with use of aromatase inhibitors in management of infertile men with low testosterone to estradiol ratios

Gregoriou¹,

Bakas²,

Grigoriadis³

et al. 2012

Fertility and Sterility

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Section: Discussionmentioning

confidence: 99%

Changes in hormonal profile and seminal parameters with use of aromatase inhibitors in management of infertile men with low testosterone to estradiol ratios

Gregoriou¹,

Bakas²,

Grigoriadis³

et al. 2012

Fertility and Sterility

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“…Although all of these agents based on a rationale, they do not always achieve success and there is no reliable treatment to boost fertility. [7][8][9] Aromatase is an enzyme mostly located in testis, liver and brain, and converts irreversibly testosterone to estradiol. Testosterone is essential for spermatogenesis and decreased testosterone/ estradiol ratio is mostly associated with male infertility.…”

Section: Discussionmentioning

confidence: 99%

Histopathologic Effects of Anastrozole an Aromatase Enzyme Inhibitor on Rat Testicles

Öğreden¹,

Benli̇²,

Yariş³

et al. 2015

Turkiye Klinikleri J Urology

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A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : To investigate effects of anastrozole that used for idiopathic male infertility on testicular histopathology. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Twenty-eight rats were divided into four groups. Group I included rats that were given saline solution (placebo). Group II included rats that received low dose of anastrozole (0.001 mg/kg). Group III included rats that received routine dose of anastrozole (0.01 mg/kg). Group IV included rats that received high dose of anastrozole (0.1 mg/kg). Anastrozole was administered to treatment groups for 21 days and at the end of the treatment period, testicles were removed for histopathologic examination. R Re es su ul lt ts s: : Spermatogenetic activity was normal in 6, 5, 4 and 3 rats in group 1, group 2, group 3 and group 4, respectively. Slight testicular atrophy was detected in 1, 2, 2 and 1 rats in group1, group2, group 3 and group 4, respectively. Severe/complete testicular atrophy was detected in 1 rat in group 3 and in 3 rats in group 4. No severe/complete testicular atrophy was detected in groups 1 and 2. Leydig cells were hyperplastic in 1 rat in group 1 and in 2 rats in group 2. Leydig cells were hyperplastic in rats that had severe or complete atrophy in group 3. Leydig cells were hyperplastic in rats that had mild and complete atrophy in group 4. Basal lamina appeared normal in all groups. C Co on nc cl lu us si io on n: : High dose anastrozole treatment results in a significant decrease in testicular size. Although it was not statistically significant, mild and total atrophy and hyperplasia in leydig cells secondary to atrophy were also detected.

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“…In a study by Reifsnyder et al, the group did not see an improvement in sperm retrieval rate, clinical pregnancy, or birth rates in 1054 men undergoing microdissection TESE after treatment with clomiphene, hCG, or aromatase inhibitors pre-operatively if total testosterone was <300 ng/dL versus untreated, euandrogenic controls [54]. Additionally, there is a subset of patients where clomiphene citrate induces a paradoxical response, decreasing testosterone levels, or semen parameters [55,56]. The exact mechanism of this paradoxical effect is unclear; however, it may be explained by the molecular compounds that comprise clomiphene citrate.…”

Section: Clomiphene Citratementioning

confidence: 97%

Hormone-Based Treatments in Subfertile Males

2016

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Subfertility is defined as the condition of being less than normally fertile though still capable of effecting fertilization. When these subfertile couples seek assistance for conception, a thorough evaluation of male endocrine function is often overlooked. Spermatogenesis is a complex process where even subtle alterations in this process can lead to subfertility or infertility. Male endocrine abnormalities may suggest a specific diagnosis contributing to subfertility; however, in many patients, the underlying etiology is still unknown. Optimizing underlying endocrine abnormalities may improve spermatogenesis and fertility. This manuscript reviews reproductive endocrine abnormalities and hormone-based treatments.

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Azoospermia after treatment with clomiphene citrate in patients with oligospermia

Cited by 44 publications

References 2 publications

Changes in hormonal profile and seminal parameters with use of aromatase inhibitors in management of infertile men with low testosterone to estradiol ratios

Changes in hormonal profile and seminal parameters with use of aromatase inhibitors in management of infertile men with low testosterone to estradiol ratios

Histopathologic Effects of Anastrozole an Aromatase Enzyme Inhibitor on Rat Testicles

Hormone-Based Treatments in Subfertile Males

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