Azobenzene-grafted carboxymethyl cellulose hydrogels with photo-switchable, reduction-responsive and self-healing properties for a controlled drug release system

Kim, Young S.; Jeong, Dae‐Yong; Shinde, Vijay Vilas; Hu, Yan‐Yan; Kim, Chulgu; Jung, Seunho

doi:10.1016/j.ijbiomac.2020.07.071

Cited by 56 publications

(30 citation statements)

References 51 publications

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“…Indeed, CD dimers can interact with hosts [ 77 , 89 ] and this interaction can have an important physicochemical involvement. Kim et al in 2020 synthesized azobenzene-grafted carboxymethyl cellulose (CMC) hydrogels for a controlled drug release system [ 90 ]. This system was photo-switchable, reduction-responsive and self-healing as it is seen in Figure 13 .…”

Section: Cellulosementioning

confidence: 99%

Azo-Dyes-Grafted Oligosaccharides—From Synthesis to Applications

Léonard

Fayeulle

2021

Molecules

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Azobenzenes are photochromic molecules that possess a large range of applications. Their syntheses are usually simple and fast, and their purifications can be easy to perform. Oligosaccharide is also a wide family of biopolymer constituted of linear chain of saccharides. It can be extracted from biomass, as for cellulose, being the principal constituent of plant cell wall, or it can be enzymatically produced as for cyclodextrins, having properties not far from cellulose. Combining these two materials families can afford interesting applications such as controlled drug-release systems, photochromic liquid crystals, photoresponsive films or even fluorescent indicators. This review will compile the different syntheses of azo-dyes-grafted oligosaccharides, and will show their various applications.

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Section: Cellulosementioning

confidence: 99%

Azo-Dyes-Grafted Oligosaccharides—From Synthesis to Applications

Léonard

Fayeulle

2021

Molecules

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“…The classification of self-healing mechanisms is summarized in Table 2 and is presented in Figure 3. [66,67] Acylhydrazone bonds [68,69] Microcapsule [70,71] Host-guest interactions [72][73][74] Boronate-diol complexation [75,76] Hydrogen bond [77][78][79] Diels-Alder click chemistry [80][81][82] Hydrophobic interactions [83,84] Disulfide bonds [85,86] π-π stacking [87,88] Imine bonds (Schiff base) [89,90] Electrostatic (or ionic) interaction is based on the interaction between ions incorporated into the HG matrix ( Figure 3A). By the mutual attraction of oppositely charged ions or ions and polymer chains, the HG structure can be reconstructed, e.g., between two pieces of HG placed on each other [66].…”

Section: Self-healingmentioning

confidence: 99%

“…Again, no significant differences between the initial and healed HG were observed. Another study presented the host-guest relationship between cyclodextrin and azobenzene, showing that the additional presence of agarose improved and enhanced the self-healing properties of the HG structure [74].…”

Section: Self-healingmentioning

confidence: 99%

Hydrogel Properties and Their Impact on Regenerative Medicine and Tissue Engineering

Chyzy

Płońska‐Brzezińska

2020

Molecules

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Hydrogels (HGs), as three-dimensional structures, are widely used in modern medicine, including regenerative medicine. The use of HGs in wound treatment and tissue engineering is a rapidly developing sector of medicine. The unique properties of HGs allow researchers to easily modify them to maximize their potential. Herein, we describe the physicochemical properties of HGs, which determine their subsequent applications in regenerative medicine and tissue engineering. Examples of chemical modifications of HGs and their applications are described based on the latest scientific reports.

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“…Hydrogels containing β‐cyclodextrin also respond to multiple stimuli, including temperature, UV light, pH, and competitive guests, depending on the guest molecules. [ 43–48 ]…”

Section: Introductionmentioning

confidence: 99%

Stimuli‐Responsive, Self‐Healing, and Injectable Hydrogels with Dual‐Crosslinked Design from Phenolphthalein‐Grafted N‐Carboxyethyl Chitosan

Savetsakulanont

Chalitangkoon

Monvisade

2021

Macro Materials & Eng

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A new biomaterial, a hydrogel, with dual‐crosslinked design, has been created with enhanced mechanical performance. The hydrogels are fabricated based on water‐soluble chitosan, with dual‐crosslinking of imine linkages and host–guest interactions. Phenolphthalein‐grafted N‐carboxyethyl chitosan (CECS‐g‐PHP), as a guest polymer, is synthesized and structurally characterized and complexed with hexamethylenediamine modified β‐cyclodextrin (β‐CD‐HDA), as a host molecule. Oxidized sodium alginate (OSA) is added to form crosslinking networks via imine linkages with the existing amino groups. The hydrogels show significantly shorter gelation times and higher compressive stresses, compared with single‐crosslinked hydrogels. The phenolphthalein units in the hydrogel change color with pH and other added chemicals. Moreover, the hydrogels can be injected and are self‐healing with >80% recovery within 4 h. Thus, these dual‐crosslinked hydrogels, which respond to pH and other stimuli, are promising designs for new multifunctional biomaterials.

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Azobenzene-grafted carboxymethyl cellulose hydrogels with photo-switchable, reduction-responsive and self-healing properties for a controlled drug release system

Cited by 56 publications

References 51 publications

Azo-Dyes-Grafted Oligosaccharides—From Synthesis to Applications

Azo-Dyes-Grafted Oligosaccharides—From Synthesis to Applications

Hydrogel Properties and Their Impact on Regenerative Medicine and Tissue Engineering

Stimuli‐Responsive, Self‐Healing, and Injectable Hydrogels with Dual‐Crosslinked Design from Phenolphthalein‐Grafted N‐Carboxyethyl Chitosan

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