“…Basic reaction conditions allowed unwanted retro‐aldol reactions, and silane scavengers gave decomposition products through hydride attack at the α,β‐unsaturated carbonyl moiety . Nevertheless, reliable protocols for solid‐phase peptide synthesis were developed, and the coupling reagents 1‐ethyl‐3‐(3‐dimethylaminopropyl)carbodiimide (EDC), N,N,N′,N′‐tetramethyl‐O‐(1H‐benzotriazol‐1‐yl)uronium hexafluorophosphate (HBTU), 1‐[bis(dimethylamino)methylen]‐5‐chlorobenzotriazolium 3‐oxide hexafluorophosphate (HCTU), benzotriazol‐1‐yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP), and diphenylphosphoryl azide (DPPA) were successfully employed …”