Enhanced user-control of small molecule drug release from a poly(ethylene glycol) hydrogel via azobenzene/cyclodextrin complex tethers

Nehls, Eric M.; Rosales, Adrianne M.; Anseth, Kristi S.

doi:10.1039/c5tb02004b

Cited by 43 publications

(22 citation statements)

References 33 publications

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“…423 Photo-switchable azobenzene moieties have been used to reversibly alter thermal properties in linear structures 424,425 or mechanical properties in networks. [426][427][428][429][430][431] The same moiety was critical to the all-optical control of shape deformation and shape restoration in photoresponsive liquid crystal elastomers. 432 Furthermore, the dynamic nature of azobenzene moiety was employed to create light-driven chiroptical switches.…”

Section: Resultsmentioning

confidence: 99%

Stereochemical enhancement of polymer properties

et al. 2019

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The importance of stereochemistry to the function of molecules is generally well understood. However, to date, control over stereochemistry and its potential to influence properties of the resulting polymers are, as yet, not fully realised. This review focuses on the state-of-the-art with respect to how stereochemistry in polymers has been used to influence and control their physical and mechanical properties as well as begin to control their function. A brief overview of the synthetic methodology by which to access these materials is included, with the main focus directed towards stereochemical control over properties such as mechanical, biodegradation and conductivity. Additionally, the advances being made towards enantioseparation, enantioselective catalyst supports and stereo-directed transitions are discussed. Finally, we also consider the opportunities that the rich stereochemistry of sustainably-sourced monomers could offer in this field. Where possible, parallels and general design principles are drawn together to identify opportunities and limitations that these approaches may present in their effects on materials properties, performance and function.

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Section: Resultsmentioning

confidence: 99%

Stereochemical enhancement of polymer properties

et al. 2019

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“…Gupta and coworkers pioneered the design of photoresponsive nanogels based on the hydrophobic association of azobenzenemodified dextran. [109] Host-guest complexes between an azobenzene functionalized peptide as model drug and a fourarm PEGbased hydrogel functionalized with βcyclodextrin were shown to regulate the drug release under irradiation with 365 nm light. A more recent example of an azobenzene host-guest interactionbased release mecha nism capable to photocontrol the release of a model drug was given by Anseth and coworkers.…”

Section: Controlled Drug Releasementioning

confidence: 99%

Design and Applications of Photoresponsive Hydrogels

2019

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materials with diverse applications in var ious fields due to their tunable chemistry structure and physical properties as well as excellent biocompatibility. [2][3][4][5] Hydrogel research has evolved from static mate rials to smart ones, whose structures and property show responsiveness to external stimuli, including temperature, pH, light, electric or magnetic fields, and the pres ence of enzymes or ion concentrations. [6][7][8][9][10][11] This unprecedented level of control over material properties has driven both med ical and industrial fields into the realm of possibility: controlled drug delivery, [12] chemical sensors, [13] soft actuators or robotics, [14][15][16] or scaffolds for dynamic 3D cell culture. [17] Photoresponsiveness is attractive due to the inherent advan tages of light as stimulus. Light is non invasive and allows remote manipulation of materials without requiring additional reagents, thus, with limited byproducts. Modulation of irradiation parameters, such as light intensity and irradiation time, permits the pre cise control of irradiation dosage, thereby, the degree of photo reactions. Spatial control can be achieved in both 2D and 3D, and temporal control is possible by simply turning the respec tive light source on or off. Wavelengthselective photo chemical reactions can be used for orthogonal photomediation of hydrogel properties. [18] Photoresponsive hydrogels, as externally tunable materials, strongly contribute to the field of soft smart materials in regard to the abovementioned applications. [19] In this review, we elaborate on the design and the emerging appli cations of photoresponsive hydrogels. A comprehensive review about utilizing light for the formation of hydrogels is given by Mi and coworkers. [20] First, we discuss responsive modes and photochemical mechanisms of photoresponsive hydrogels. Fol lowing this, we highlight their applications for dynamic cell environments, smart biointerfaces, controlled drug delivery, photodriven actuators, and lighthealing materials. The review concludes with an outlook on the challenges and potential future approaches for photo responsive hydrogels. Light as Stimulus for Hydrogels Macroscopic Hydrogel PhotoresponsesThe interaction of light with photoresponsive hydrogels can result in different responses, some of which are observable with the bare eye. Those include hydrogel formation or degradation, network contraction or expansion, and chemical modifications in the network, which then have an immediate consequence on Hydrogels are the most relevant biochemical scaffold due to their tunable properties, inherent biocompatibility, and similarity with tissue and cell environments. Over the past decade, hydrogels have developed from static materials to "smart" responsive materials adapting to various stimuli, such as pH, temperature, chemical, electrical, or light. Light stimulation is particularly interesting for many applications because of the capability of contact-free remote manipulation of biomaterial properties and inherent spatial and t...

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“…Upon light irradiation, such hydrogels undergo reversible gel-sol transitions due to the cis-trans photoisomerization of azobenzene units. [177,178] Chen et al reported such an injectable NC hydrogel for sustained cancer treatment (Figure 7). The NC hydrogel was prepared through hostguest chemistry-based crosslinking.…”

Section: Light-responsive Injectable Hydrogels For Controlled and Locmentioning

confidence: 99%

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Rizzo

Kehr

2020

Adv Healthcare Materials

209

152

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Injectable hydrogels have received considerable interest in the biomedical field due to their potential applications in minimally invasive local drug delivery, more precise implantation, and site‐specific drug delivery into poorly reachable tissue sites and into interface tissues, where wound healing takes a long time. Injectable hydrogels, such as in situ forming and/or shear‐thinning hydrogels, can be generated using chemically and/or physically crosslinked hydrogels. Yet, for controlled and local drug delivery applications, the ideal injectable hydrogel should be able to provide controlled and sustained release of drug molecules to the target site when needed and should limit nonspecific drug molecule distribution in healthy tissues. Thus, such hydrogels should sense the environmental changes that arise in disease states and be able to release the optimal amount of drug over the necessary time period to the target region. To address this, researchers have designed stimuli‐responsive injectable hydrogels. Stimuli‐responsive hydrogels change their shape or volume when they sense environmental stimuli, e.g., pH, temperature, light, electrical signals, or enzymatic changes, and deliver an optimal concentration of drugs to the target site without affecting healthy tissues.

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Enhanced user-control of small molecule drug release from a poly(ethylene glycol) hydrogel via azobenzene/cyclodextrin complex tethers

Cited by 43 publications

References 33 publications

Stereochemical enhancement of polymer properties

Stereochemical enhancement of polymer properties

Design and Applications of Photoresponsive Hydrogels

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

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