Azithromycin as an adjunctive treatment of aggressive periodontitis: 12‐months randomized clinical trial

Haas, Alex Nogueira; Castro, Gabriel Dias de; Moreno, Tatiana; Susin, Cristiano; Albandar, Jasim M.; Oppermann, Rui Vicente; Rösing, Cassiano Kuchenbecker

doi:10.1111/j.1600-051x.2008.01254.x

Cited by 104 publications

(169 citation statements)

References 53 publications

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“…Clinical studies have documented the presence of remaining biofilm despite good levels of plaque control. 7,8 The consumption of oral hygiene products has increased worldwide. For example, less than one toothbrush per capita was consumed in the 1990s in Brazil.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of two soft-bristle toothbrushes in plaque removal: a randomized controlled trial

et al. 2016

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The aim of this study was to compare the efficacy in supragingival plaque removal of two soft-bristle toothbrushes. Seventy volunteers were allocated randomly to the Colgate SlimSoft or Curaprox CS5460 toothbrush grourps. At baseline appointment, volunteers underwent plaque examination using the Rustogi Modification of the Navy Plaque Index. Under supervision, they then brushed their teeth for 1minute with their assigned toothbrushes and the plaque examination was repeated. Volunteers performed daily oral hygiene with their assigned toothbrush and a regular dentifrice provided by the researchers for 7 days. The baseline experimental procedures were then repeated. Separate analyses of variance were performed for the whole-mouth, interproximal, and gumline plaque scores (p < 0.05). No difference in baseline pre-brushing scores was found between groups. After a single toothbrushing, the mean plaque score was significantly reduced in both groups (p < 0.05), with greater reduction of whole-mouth and interproximal plaque scores observed in the SlimSoft group compared with the Curaprox group (p < 0.05). After 7 days, the SlimSoft group showed greater reduction of the whole-mouth and interproximal plaque scores compared with the Curaprox group (p < 0.05). In conclusion, the SlimSoft toothbrush presented greater efficacy in supragingival plaque removal than did the Curaprox CS5460 toothbrush, as reflected by whole-mouth and interproximal plaque scores.

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Section: Introductionmentioning

confidence: 99%

Efficacy of two soft-bristle toothbrushes in plaque removal: a randomized controlled trial

et al. 2016

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“…Studies demonstrated that the use of systemic antimicrobial agents adjunct to mechanical periodontal treatment may be an important therapeutic strategy in the treatment of chronic [2][3][4] and aggressive [5][6][7][8][9] periodontal diseases. These results were observed with the use of different antibiotics, such as amoxicillin/metronidazole 4,[8][9][10][11] , azythromicin [12][13][14] , clindamycin 15 and clarithromycin 16 , which showed favorable results as adjunct to therapy for aggressive periodontitis and chronic periodontal disease, when compared with the control group treated with mechanical therapy alone. In addition to the effects of systemic antibiotic therapy based on the isolated use of a certain drug, the use of associations of antibiotics has also shown promising clinical and microbiological results 3,5,8,17 .…”

Section: Introductionmentioning

confidence: 68%

“…In this regard, various researchers showed that there was a significant benefit of their use as adjunct to mechanical treatment, when compared with individuals who received mechanical treatment only 5,6 . Haas et al 12 (2008) used an antibiotic regime of 500 mg azythromicin, once a day, for 3 days, associated with root scaling and planing, and after 12 months of follow-up, obtained significant improvement in the evaluated clinical parameters (probing depth and clinical attachment level) in comparison with the group that received mechanical therapy alone. In addition to the clinical benefits, some recent studies also reported the positive effects of the adjunct use of antibiotics on the subgingival microbiota of individuals with aggressive periodontitis.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the use of systemic antimicrobial agents by professionals for the treatment of periodontal diseases

Monteiro¹,

Ribeiro²,

Casarin³

et al. 2013

Braz. J. Oral Sci.

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Aim: To investigate the indication of systemic antimicrobial agents used by dental professionals for treatment of patients affected by periodontal diseases. Methods: Interviews by a questionnaire were held with 225 professionals of different dental specialties and who performed periodontal treatment. Results: Among interviewees, 94% indicated systemic antibiotics as a form of periodontal disease treatment. Their main indication was for periodontal abscesses (80%) followed by aggressive periodontitis (62%) and necrotizing diseases (45%). The most frequently used antibiotics were amoxicillin (81%) and metronidazole (57%). The medications were indicated in association with mechanical therapy by 67% of the professionals. As regards the occasion of indication, 60% indicated systemic antibiotic therapy before and after mechanical periodontal scaling and root planing. Seventy-eight percent of the professionals indicated antibiotics associated with periodontal surgery for access to scaling, and 76% indicated it before and after the surgical procedure. Among the interviewees, 99% took into account systemic involvement for drug administration. Conclusions: It was concluded that a considerable portion of professionals indicate systemic antibiotic-therapy in an incoherent manner and in situations in which there is no indication for antibiotic use, or with ineffective protocols.

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“…Azithromycin is another who presented antimicrobial clinical benefits (PD and CAL) in AP treatment when associated with the SRP for a period of 12 months. In addition, the researchers noted that this is a protocol that requires less time and dosage, which facilitates the patient's collaboration 43 .…”

Section: Antibioticsmentioning

confidence: 99%

Auxiliary chemical therapies in the treatment of aggressive periodontitis: current aspects

Ayub

Júnior

Grisi

et al. 2015

RGO, Rev. Gaúch. Odontol.

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Aggressive periodontitis, a distinct clinical entity of periodontal disease, is characterized by a pronounced episodic and rapid destruction of periodontal tissues and may result in rapid and RESUMOA periodontite agressiva, uma entidade clínica distinta da doença periodontal, é caracterizada por uma pronunciada destruição episódica e rápida dos tecidos periodontais e pode resultar em perda rápida e precoce dos dentes. Alguns trabalhos têm mostrado que o debridamento mecânico convencional juntamente com higiene oral muitas vezes não é suficiente para o controle da doença. Apesar de não existir consenso, estudos recentes desta condição mostram efeitos benéficos de terapias auxiliares ou coadjuvantes como a administração de antimicrobianos sistêmicos e locais. Entre os coadjuvantes locais, a literatura apresenta os antissépticos, antibióticos e terapia fotodinâmica. Dentre os sistêmicos são representados os antibióticos e antiinflamatórios. Independentemente dos resultados apresentados por cada um deles, se reconhece a dificuldade em se estabelecer um protocolo único para todos os casos em função da resposta individual apresentada por cada paciente. O objetivo do presente estudo foi revisar os resultados atuais sobre administração de coadjuvantes químicos associados à terapia convencional em casos de periodontite agressiva e sugerir protocolos clínicos.Termos de indexação: Periodontite agressiva. Antibacterianos. Anti-infecciosos locais. Antissépticos bucais. Anti-inflamatórios. Fotoquimioterapia. and alveolar bone destruction and c) family concentration of cases. The diagnosis of AP requires the exclusion of systemic diseases that may harm the host defense and lead to premature teeth loss (periodontal manifestations of systemic diseases). Auxiliary chemical therapies in the treatment of aggressive periodontitis: current aspectsThe existence of particular forms of AP was also recognized based on specific clinical and lab characteristics: localized aggressive periodontitis (LAP) and generalized aggresssive periodontitis (GAP) 2 .A successful treatment of AP is dependent of early diagnosis, directing the therapy to the elimination or deletion of pathogens, providing a favorable

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Azithromycin as an adjunctive treatment of aggressive periodontitis: 12‐months randomized clinical trial

Abstract: The adjunctive use of azithromycin has the potential to improve periodontal health of young patients with AgP.

Cited by 104 publications

References 53 publications

Efficacy of two soft-bristle toothbrushes in plaque removal: a randomized controlled trial

Efficacy of two soft-bristle toothbrushes in plaque removal: a randomized controlled trial

Evaluation of the use of systemic antimicrobial agents by professionals for the treatment of periodontal diseases

Auxiliary chemical therapies in the treatment of aggressive periodontitis: current aspects

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