Azide-functionalized hollow silica nanospheres for removal of antibiotics

Gao, Jinsuo; Chen, Jingjing; Li, Xiaona; Wang, Meiwen; Zhang, Xueying; Tan, Feng; Xu, Shutao; Liu, Jian

doi:10.1016/j.jcis.2014.12.054

Cited by 33 publications

(22 citation statements)

References 35 publications

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“…Another passive functional group, poly(ethylene oxide), can be used to tune the surface charge of silica nanocapsules which, in turn, reduced the damaging interactions of the nanocapsules with red blood cells and platelets [107]. Reactive organic functional groups can also be incorporated onto silica shells to provide facile linker chemistry (e.g., thiol [98][99][100], azide [101], alkyl [102,105], epoxide [32], amine [103,104,106], or alkoxy [107]). The linker is especially important for conjugating various functional molecules or biomolecules onto the surfaces of silica nanocapsules, including stimuli-responsive materials (e.g., chitosan [32] and α-cyclodextrine [20,108]), targeting molecules (e.g., antibody [16] and folic acid [20]), fluorescence imaging agents (e.g., near-IR dye [16], coumarin blue dye [57], fluorescein isothiocyanate [31,58,64], and rhodamine B…”

Section: Biomoleculesmentioning

confidence: 99%

“…The silanol groups enable conjugation of organic functional groups either through covalent siloxane bonds or electrostatic interactions.There are two approaches that are commonly used for incorporating functional organic moieties onto silica shells through formation of covalent bonds, i.e., co-condensation and postsynthetic grafting. Using co-condensation methods, an organoalkoxysilane compound is added together with a silica precursor such as TEOS during the synthesis of silica nanocapsules (onepot)[98][99][100][101][102]. In contrast, a post-synthetic grafting process facilitates conjugation of organic functional groups to the exposed silica surfaces after the silica nanocapsules are formed[32,[103][104][105][106][107].…”

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confidence: 99%

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Interfacial engineering for silica nanocapsules

Wibowo

Hui

Middelberg

et al. 2016

Advances in Colloid and Interface Science

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Silica nanocapsules have attracted significant interest due to their core-shell hierarchical structure. The core domain allows the encapsulation of various functional components such as drugs, fluorescent and magnetic nanoparticles for applications in drug delivery, imaging and sensing, and the silica shell with its unique properties including biocompatibility, chemical and physical stability, and surface-chemistry tailorability provides a protection layer for the encapsulated cargo. Therefore, significant effort has been directed to synthesize silica nanocapsules with engineered properties, including size, composition and surface functionality, for various applications. This review provides a comprehensive overview of emerging methods for the manufacture of silica nanocapsules, with a special emphasis on different interfacial engineering strategies. The review starts with an introduction of various manufacturing approaches of silica nanocapsules highlighting surface engineering of the core template nanomaterials (solid nanoparticles, liquid droplets, and gas bubbles) using chemicals or biomolecules which are able to direct nucleation and growth of silica at the boundary of two-phase interfaces (solid-liquid, liquid-liquid, and gas-liquid). Next, surface functionalization of silica nanocapsules is presented. Furthermore, strategies and challenges of encapsulating active molecules (pre-loading and post-loading approaches) in these capsular systems are critically discussed. Finally, applications of silica nanocapsules in controlled release, imaging, and theranostics are reviewed.

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Section: Biomoleculesmentioning

confidence: 99%

mentioning

confidence: 99%

Interfacial engineering for silica nanocapsules

Wibowo

Hui

Middelberg

et al. 2016

Advances in Colloid and Interface Science

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“…For surface Huisgen click reaction, reflection infrared techniques , Raman and X‐ray photoelectron spectroscopy (XPS) have been employed with success. Particularly XPS brought strong supporting evidence for tracking the change in the surface chemical composition of materials after attachment of azido‐functionalized compounds to the surface followed by surface‐confined click reactions resulting in the attachment of polymers , biomacromolecules or metallic nanoparticles .…”

Section: Introductionmentioning

confidence: 99%

X-ray induced degradation of surface bound azido groups during XPS analysis

Saad

Abderrabba

Chehimi

2016

Surf. Interface Anal.

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Mesoporous silica SBA‐15 was synthesized and silanized with azidopropyl triethoxysilane in order to design a clickable material. Fourier transform infrared analysis permitted to prove the attachment of the azidopropylene groups to SBA‐15 resulting in the reactive and functional material N3‐SBA‐15. X‐ray photoelectron spectroscopy was used to determine the surface composition of SBA‐15. However, we unexpectedly found that the surface bound azido groups undergo X‐ray induced decomposition during the X‐ray photoelectron spectroscopy analysis resulting in the formation of nitrenes. These are very reactive groups able to intercalate C―C and C―H bonds of the propylene chains as judged from the N1s peak shape. Possible mechanisms of intercalation are suggested. C1s and N1s peaks were recorded at different exposure time. N/C, N+/N and N+/C undergo exponential decay. N+/N reaches the value of zero in less than 80 min of exposure to the X‐ray source. The N+/C decay plot was fitted with first‐order kinetics, and the decomposition kinetic constant (kdec) was found to equal to 516.4 s−1. This is a fast X‐ray induced degradation which must be considered with care when examining clickable materials with surface bound alkyl azido groups. Copyright © 2016 John Wiley & Sons, Ltd.

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“…Although, these processes showed good efficiencies the technical complexity, the use of chemicals associated with relatively high costs have hindered their use. On the other hand, adsorption has been considered one of the most effective method for antibiotic removal and different materials such as polystyrene resins [11], silica nanospheres [12], zeolite [13], birnessite [14], graphene [15,16] have been investigated. Specifically for the adsorption of ␤-lactam antibiotics several materials such as carbon nanotubes [17], activated carbon [18] and bentonite [19] have been investigated.…”

Section: Introductionmentioning

confidence: 99%