Azabrendanes V. Synthesis and reactions of stereoisomeric exo- and endo-5-aminomethylbicyclo[2.2.1]hept-2-ene-based ureas

“…The individuality of the constituent parts of the city at different levels of its organization is determined by the following properties: compositional (harmonious and regular organization of constituent elements), geometricity (spatial arrangement (architectonics), typology (commonality of signs), morphology, functionality (designation of territory), interconnection of the main functional zones and systems of connections between them (planning) 1 . They make it possible to consider the structure of the city not only as a certainly organized territory, but also for construction material (the physical structure of the city), which has distinctive features.…”

Section: № 5(45) Vol1 May 2019mentioning

confidence: 99%

“…The methodological basis for the study are the philosophical and ideological [1,2,3], axiomatic [4], systemic [5,6] and interdisciplinary [7] approaches. The philosophical approach formed the scientific position concerning the subject of the study.…”

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confidence: 99%

Methodological Bases of the Study of Morphological Characteristics of the City

Idak

2019

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The aim of the study is to formulate the basic theoretical positions and to substantiate the methodological approaches to the study of morphological characteristics of the city. They are connected with the process of studying of the form and structure of the city with the help of morphology as a science. The methodological basis of the study is the philosophical- ideological, axiomatic, systemic and interdisciplinary approaches.

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“…The model reaction of succinic anhydride and methylamine is studied in the gas phase and in the nonpolar solution. We selected benzene as a neutral, aprotic solvent, which is used for aminolysis of anhydrides in organic synthesis , and is not expected to have a catalytic effect. Kinetic investigations of the aminolysis reaction in benzene also have been carried out for the interaction between benzylamine and succinic anhydride by Smagowski and Bartnicka .…”

Section: Introductionmentioning

confidence: 99%

Computational Study of the Aminolysis of Anhydrides: Effect of the Catalysis to the Reaction of Succinic Anhydride with Methylamine in Gas Phase and Nonpolar Solution

et al. 2008

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Different possible pathways of the aminolysis reaction of succinic anhydride were investigated by applying high level electronic structure theory, examining the general base catalysis by amine and the general acid catalysis by acetic acid, and studying the effect of solvent. The density functional theory at the B3LYP/6-31G(d) and B3LYP/6-311++G(d,p) levels was employed to investigate the reaction pathways for the aminolysis reaction between succinic anhydride and methylamine. The single point ab initio calculations were based on the second-order Møller-Plesset perturbation theory (MP2) with 6-31G(d) and 6-311++G(d,p) basis sets and CCSD(T)/6-31G(d) level calculations for geometries optimized at the B3LYP/6-311++G(d,p) level of theory. A detailed analysis of the atomic movements during the process of concerted aminolysis was further obtained by intrinsic reaction coordinate calculations. Solvent effects were assessed by the polarized continuum model method. The results show that the concerted mechanism of noncatalyzed aminolysis has distinctly lower activation energy compared with the addition/elimination stepwise mechanism. In the case of the process catalyzed by a second methylamine molecule, asynchronous proton transfer takes place, while the transition vectors of the acid-catalyzed transition states correspond to the simultaneous motion of protons. The most favorable pathway of the reaction was found through the bifunctional acid catalyzed stepwise mechanism that involves formation of eight-membered rings in the transition state structures. The difference between the activation barriers for the two mechanisms averages 2 kcal/mol at various levels of theory.

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Azabrendanes V. Synthesis and reactions of stereoisomeric exo- and endo-5-aminomethylbicyclo[2.2.1]hept-2-ene-based ureas

Cited by 6 publications

References 21 publications

Azacycloalkanes from epoxides and aziridines

Azacycloalkanes from epoxides and aziridines

Methodological Bases of the Study of Morphological Characteristics of the City

Computational Study of the Aminolysis of Anhydrides: Effect of the Catalysis to the Reaction of Succinic Anhydride with Methylamine in Gas Phase and Nonpolar Solution

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