Aylthonic acid, a new tetranorneoclerodane from Aylthonia macrantha (Velloziaceae)

3',8"-biisokaempferide, a cytotoxic biflavonoid and other chemical constituents of Nanuza plicata (Velloziaceae)

“…1 These plants live under conditions of high solar irradiation and low water availability. 2 Species of this family contain high amounts of diterpenes with a skeleton of the clerodane, 2 cleisthantane, isopimarane, 3 kaurane, 4 and labdane 5 types, besides flavonoids monoisoprenylated, C-alkylated and biflavonoids. [6][7][8][9] The genus Nanuza comprises three species, N. plicata, N. almeidae and N. luetzelburgii.…”

“…Foi isolado das folhas de Nanuza plicata um novo biflavonóide, chamado 3',8''-biisocampferideo (1), juntamente com os conhecidos compostos amentoflavona (2), ácido patagônico (3), (4aR,5S,6R,8aR)-5-[2-(2,5-dihidro-5-metóxi-2-oxofuran-3-il)etil]-3,4,4a,5,6,7,8, 8a-octahidro-5,6,8a-trimetilnaftaleno-1-ácido carboxílico (4), cafeoilquinato de metila (5), ácido 3,5-di-cafeoilquínico (6) e luteolina (7). Os compostos 3, 4, 5 e 6 são relatados pela primeira vez em Velloziaceae.…”

“…A citotoxicidade de 3',8''-biisocampferideo foi estudada em células de glioblastoma humano (GL-15). A concentração efetiva, que produziu morte em 50% das células após 72 h foi 36,5 μmol L A novel biflavonoid, named 3',8''-biisokaempferide (1), along with the known compounds amentoflavone (2), patagonic acid (3), (4aR,5S,6R,8aR)-5-[2-(2,5-Dihydro-5-methoxy-2-oxofuran-3-yl)ethyl]-3,4,4a,5,6,7,8,8a-octahydro-5,6,8a-trimethylnaphthalene-1-carboxylic acid (4), 5-caffeoylquinic acid methyl ester (5), 3,5-di-caffeoylquinic acid (6) and luteolin (7), were isolated of the leaves from Nanuza plicata. The compounds 3, 4, 5 and 6 are reported for the first time in Velloziaceae.…”

Tetranorclerodanes and Clerodane-Type Diterpene Glycosides from Dicranopteris dichotoma

“…The acetone extract of Dicranopteris dichotoma afforded two new tetranorclerodanes, 18-hydroxyaylthonic acid (1) and 18-oxo-aylthonic acid (2) 6), together with two known compounds, aylthonic acid (7) and (6S,13S)-cleroda-3,14-diene-6,13-diol (8). The structures of these new compounds were established by a combination of 1D and 2D NMR techniques, MS, and acid hydrolysis.…”

“…and reported the isolation and structural elucidation of two new highly oxygenated phenolic derivatives, dichotomains A and B. 6 Continuous screening of the fronds of D. dichotoma led to the discovery of two new tetranorclerodanes, 18hydroxyaylthonic acid (1) and 18-oxo-aylthonic acid (2) 6), together with two known compounds, aylthonic acid (7) 7 and (6S,13S)-cleroda-3,14-diene-6,13-diol (8). 6 In the present paper, we report the structural characterization of compounds 1-8 and their anti-HIV-1 activities.…”