Axono-cortical evoked potentials: A proof-of-concept study

Mandonnet, Emmanuel; Dadoun, Y; Poisson, Isabelle; Madadaki, C.; Froelich, Sébastien; Lozeron, Pierre

doi:10.1016/j.neuchi.2015.09.003

Cited by 20 publications

(17 citation statements)

References 9 publications

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“…The measured latencies of the first negative peak were around 20 ms in accordance with those measured in Matsumoto's group both for CCEPs and ACEPs [4,5]. In contrast, Mandonnet et al [6] measured shorter latencies for ACEPs (~ 10 ms). There is no precise explanation for these differences since ACEPs first propagate in the white myelinated pathways before being distributed in a cortical network where axons are not myelinated, thus constituting a limiting factor for a faster propagation.…”

Section: Discussionsupporting

confidence: 88%

“…In addition, the presence of axono-cortical evoked potentials (ACEPs) has been highlighted during the propagation of 1 Hz DES between white matter pathways and connected cortical sites [5,6]. Despite, some technical differences with these studies, we observed a similar waveform.…”

Section: Discussionsupporting

confidence: 62%

“…This interpretation is correct if it is assumed that slow myelinated axons may propagate the evoked potentials (min conduction velocity ~ 10 m/s) and cannot stand for a propagation along fast myelinated axons (max conduction velocity ~ 100 m/s). In the same vein, despite DES was applied very close to the recording site in our case (< 5 mm), the latencies differences that we measured with respect to Mandonnet et al study [6] may also be explained by an indirect cortico -local U fibers subcortical pathways -cortical propagation. This double cortical propagation (at the end and at the beginning) could be limiting for the conduction velocity.…”

Section: Discussionsupporting

confidence: 42%

“…Usually, it is considered that about 0.5 ms are necessary for the signal to cross one synapse and the conduction velocity in non-myelinated fibers is about [0.4, 2] m/s [7]. Mandonnet et al [6] suggest that the latencies observed for the negative peak are twice that measured by Yamao et al [5] and maybe due to a DES applied about 2 times further on the axon. This interpretation is correct if it is assumed that slow myelinated axons may propagate the evoked potentials (min conduction velocity ~ 10 m/s) and cannot stand for a propagation along fast myelinated axons (max conduction velocity ~ 100 m/s).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, in only two studies the presence of axonocortical evoked potentials (ACEPs) has been highlighted during the propagation of 1 Hz DES between white matter pathways and connected cortical sites [6,7]. Despite technical differences between these two studies (monophasic pulses of alternating polarity and a monopolar electrode, and classical DES parameters used in awake surgery respectively), they reported a similar negative waveform for the ACEP with a negative peak that occurred between 10 and 20 ms and a quite large width around 40 ms.…”

mentioning

confidence: 99%

See 4 more Smart Citations

A measure of cortico-cortical potentials evoked by 10Hz direct electrical stimulation of the brain and by means of a differential recording mode of electrocorticographic signals

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Duffau

et al. 2016

2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 62%

Section: Discussionsupporting

confidence: 42%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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A measure of cortico-cortical potentials evoked by 10Hz direct electrical stimulation of the brain and by means of a differential recording mode of electrocorticographic signals

Vincent

Rossel

Duffau

et al. 2016

2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

View full text Add to dashboard Cite

Probabilistic mapping of language networks from high frequency activity induced by direct electrical stimulation

Perrone‐Bertolotti

Alexandre

Jobb

et al. 2020

Human Brain Mapping

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Direct electrical stimulation (DES) at 50 Hz is used as a gold standard to map cognitive functions but little is known about its ability to map large‐scale networks and specific subnetwork. In the present study, we aim to propose a new methodological approach to evaluate the specific hypothesis suggesting that language errors/dysfunction induced by DES are the result of large‐scale network modification rather than of a single cortical region, which explains that similar language symptoms may be observed after stimulation of different cortical regions belonging to this network. We retrospectively examined 29 patients suffering from focal drug‐resistant epilepsy who benefitted from stereo‐electroencephalographic (SEEG) exploration and exhibited language symptoms during a naming task following 50 Hz DES. We assessed the large‐scale language network correlated with behavioral DES‐induced responses (naming errors) by quantifying DES‐induced changes in high frequency activity (HFA, 70–150 Hz) outside the stimulated cortical region. We developed a probabilistic approach to report the spatial pattern of HFA modulations during DES‐induced language errors. Similarly, we mapped the pattern of after‐discharges (3–35 Hz) occurring after DES. HFA modulations concurrent to language symptoms revealed a brain network similar to our current knowledge of language gathered from standard brain mapping. In addition, specific subnetworks could be identified within the global language network, related to different language processes, generally described in relation to the classical language regions. Spatial patterns of after‐discharges were similar to HFA induced during DES. Our results suggest that this new methodological DES‐HFA mapping is a relevant approach to map functional networks during SEEG explorations, which would allow to shift from “local” to “network” perspectives.

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Dissociating motor–speech from lexico-semantic systems in the left frontal lobe: insight from a series of 17 awake intraoperative mappings in glioma patients

et al. 2019

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Axono-cortical evoked potentials: A proof-of-concept study

Cited by 20 publications

References 9 publications

A measure of cortico-cortical potentials evoked by 10Hz direct electrical stimulation of the brain and by means of a differential recording mode of electrocorticographic signals

A measure of cortico-cortical potentials evoked by 10Hz direct electrical stimulation of the brain and by means of a differential recording mode of electrocorticographic signals

Probabilistic mapping of language networks from high frequency activity induced by direct electrical stimulation

Dissociating motor–speech from lexico-semantic systems in the left frontal lobe: insight from a series of 17 awake intraoperative mappings in glioma patients

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