Axonal regrowth through a collagen guidance channel bridging spinal cord to the avulsed C6 roots: Functional recovery in primates with brachial plexus injury

Liu, S.; Bodjarian, Nadia; Langlois, O; Bonnard, Anne-Sophie; Boisset, Nazaire; Peulvé, P; Said, G.; Tadié, M

doi:10.1002/(sici)1097-4547(19980315)51:6<723::aid-jnr6>3.3.co;2-j

Cited by 6 publications

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“…Among them, collagen material has been widely applied in SCI repair because of its abundance, good plasticity and great biocompatibility 30. Many types of collagen scaffolds have been tested to repair the SCI in animal models, including collagen tubes, fibers, membranes, and gels 31–35. It has been shown that the axons were regenerated and their functions were partially restored after collagen scaffold was grafted into the transected spinal cord.…”

Section: Introductionmentioning

confidence: 99%

Novel nerve guidance material prepared from bovine aponeurosis

Lin

Chen

Wang

et al. 2006

J Biomedical Materials Res

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Spinal cord injury (SCI) creates an adverse environment for axon regeneration. As a result, the axons at the injury sites begin to be atrophy, retract and lose their functions. Several strategies to promote axon regeneration at the injury site have been tested, but the progress is very limited. One of the major reasons is that the regenerated axons often extend randomly and do not reach the proper place. Fabricating linearly ordered materials as nerve guidance would be important to solve such problems. In this study, a novel type of nerve guidance material was prepared from the bovine aponeurosis, which mainly consisted of ordered collagen fibers. The processed material showed good cell compatibility and low immunogenisity. Moreover, the processed material guided the neurites outgrowth of in vitro cultured cortical neurons along its fibers. The results suggested that the processed aponeurosis would be a proper nerve guidance biomaterial for SCI repair.

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Section: Introductionmentioning

confidence: 99%

Novel nerve guidance material prepared from bovine aponeurosis

Lin

Chen

Wang

et al. 2006

J Biomedical Materials Res

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Partial Return of Motor Function in Paralyzed Legs after Surgical Bypass of the Lesion Site by Nerve Autografts Three Years after Spinal Cord Injury

Tadié

Liu

Robert

et al. 2002

Journal of Neurotrauma

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Spinal cord injuries often result in irreversible loss of motor and somatosensory functions below the lesion level. Treatment is limited to physiotherapy aimed at compensating disability. We previously showed that re-establishment of tissue continuity can be achieved in animal models through nerve autografts implanted between the rostral spinal ventral horn and the caudal ventral roots. Rostral motor neuron axons could thus reach peripheral targets, leading to some return of motor function. We used a similar approach in a paraplegic patient with stabilized clinical states three years after spinal cord traumatic damage at the T9 level. Three segments from autologous sural nerves were implanted into the right and left antero-lateral quadrant of the cord at T7-8 levels, then connected to homolateral L2-4 lumbar ventral roots, respectively. Eight months after surgery, voluntary contractions of bilateral adductors and of the left quadriceps were observed. Muscular activity was confirmed by motor unit potentials in response to attempted muscle contraction. Motor-evoked potentials from these muscles were recorded by transcranial magnetic stimulation. These data support the hypothesis that muscles have been re-connected to supra-spinal centers through motor neurons located in the rostral stump of the damaged cord. They suggest that delayed surgical reconstruction of motor pathways may contribute to partial functional recovery.

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Delayed Implantation of a Peripheral Nerve Graft Reduces Motoneuron Survival but Does Not Affect Regeneration following Spinal Root Avulsion in Adult Rats

Chai

Zhang

et al. 2004

Journal of Neurotrauma

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Adult spinal motoneurons can regenerate their axons into a peripheral nerve (PN) graft following root avulsion injury if the graft is implanted immediately after the lesion is induced. The present study was designed to determine how avulsed motoneurons respond to a PN graft if implantation takes place a few days to a few weeks later. Survival, regeneration, and gene expression changes of injured motoneurons after delayed PN graft implantation were studied. The survival rates of spinal motoneurons were 78%, 65%, 57%, or 53% if a PN graft was implanted immediately, 1, 2, or 3 weeks after root avulsion, respectively. Interestingly, most of the surviving motoneurons were able to regenerate their axons into the graft regardless of the delay. All regenerating motoneurons expressed p75, but not nNOS, while all motoneurons that failed to regenerate expressed nNOS, but not p75. p75 and nNOS may, therefore, be used as markers for success or failure to regenerate axons. In the group with immediate graft implantation, 85% of the surviving motoneurons extended axons into the PN graft, while in the groups in which implantation was delayed 1, 2, or 3 weeks, 84%, 82%, and 83% of the surviving motoneurons, respectively, were found to have regenerated into the grafts. These findings indicate that avulsed spinal motoneurons retain the ability to regenerate for at least 3 weeks, and perhaps for as long as they survive. Therefore, the delayed implantation of a PN graft after root avulsion may provide a continued conducive environment to support regeneration.

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Axonal regrowth through a collagen guidance channel bridging spinal cord to the avulsed C6 roots: Functional recovery in primates with brachial plexus injury

Cited by 6 publications

References 0 publications

Novel nerve guidance material prepared from bovine aponeurosis

Novel nerve guidance material prepared from bovine aponeurosis

Partial Return of Motor Function in Paralyzed Legs after Surgical Bypass of the Lesion Site by Nerve Autografts Three Years after Spinal Cord Injury

Delayed Implantation of a Peripheral Nerve Graft Reduces Motoneuron Survival but Does Not Affect Regeneration following Spinal Root Avulsion in Adult Rats

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