Axonal loss after traumatic optic neuropathy documented by optical coherence tomography

Medeiros, Felipe A.; Moura, Frederico Castelo; Vessani, Roberto Murad; Susanna, Remo

doi:10.1016/s0002-9394(02)02049-4

Cited by 93 publications

(53 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[9][10][11][12][13]19,20 Recently, we and Monteiro et al also reported that OCT could detect RNFL thickness reduction corresponding to band atrophy in eyes with compressive lesions at the chiasmal region. 14,21 In this study, peripapillary RNFL thickness of optic atrophy showed global reduction in all quadrantic sections consistent with previous reports on compressive optic neuropathy and traumatic optic neuropathy.…”

Section: Discussionmentioning

confidence: 74%

“…[16][17][18][19][20] From this point, it would be an important feature of optic nerve disease that foveal thickness in eyes with optic atrophy does not correlate with BCVA in our study, and be helpful in differential diagnosis. In addition, there was a tendency that an area with severe visual field loss has more marked retinal thinning at the corresponding retinal area.…”

Section: Discussionmentioning

confidence: 99%

“…14,21 In this study, peripapillary RNFL thickness of optic atrophy showed global reduction in all quadrantic sections consistent with previous reports on compressive optic neuropathy and traumatic optic neuropathy. 14,[19][20][21] Taken together, biometrical assessment of RNFL thickness with OCT reflects the loss of retinal ganglion cell axons in most cases of optic neuropathy.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7][8][9][10][11][12][13][14] In eyes with macular disease such as occult macular dystrophy, and various types of macular oedema, foveal thickness have shown a correlation with visual acuity, and alterations of macular thickness have been adopted in assessing progress of disease. [15][16][17][18] On the other hand, some studies remarked and demonstrated the decrease in peripapillary RNFL thickness in eyes with glaucoma, traumatic optic neuropathy, and compression optic neuropathy using OCT. [9][10][11][12][13][14]19,20 Although it has been reported that peripapillary RNFL thickness represents the severity of visual field loss and would be of clinical use, 14,21 little attention have been paid to the relationship between visual function and macular thickness in eyes with optic nerve disease. The purpose of the current study was to clarify the detailed characteristics of retinal damages in the macular regions due to optic nerve diseases.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Macular thickness reduction in eyes with unilateral optic atrophy detected with optical coherence tomography

Kusuhara

Nakamura

Nagai-Kusuhara

et al. 2005

Eye

View full text Add to dashboard Cite

Aims To assess the changes in macular and peripapillary retinal nerve fibre layer (RNFL) thickness in eyes with unilateral optic atrophy and to evaluate the relationship between retinal thickness and visual function. Methods Enrolled were 22 patients with unilateral optic atrophy. Macular thickness at the divided nine areas and peripapillary RNFL thickness in quadrantic sections were measured by optical coherence tomography. Thickness values in the affected eyes were compared with those in the contralateral unaffected eyes. The correlation of foveal thickness with best-corrected visual acuity (BCVA) was evaluated. The correlation between retinal thickness and the remaining visual field area circumscribed with I-4-e isopter in superior and inferior hemifield was assessed.Results Macular thinning was observed in all areas (Po0.001 in each area) other than the fovea (P ¼ 0.068). Peripapillary RNFL thickness decreased in all quadrantic sections (Po0.001 in each section). The affected to unaffected eye ratio of retinal thickness was more than 0.6 in each area. BCVA did not correlate with foveal thickness (correlation coefficient ¼ 0.094, P ¼ 0.668). Although not statistically significant (P ¼ 0.281, superior hemifield; P ¼ 0.053, inferior hemifield), there was a tendency that eyes with severe visual field loss show more marked retinal thinning. Conclusions Macular thinning with the preserved foveal thickness is a hallmark of eyes with optic atrophy. Together with no correlation between foveal thickness and BCVA, this finding would help in differential diagnosis of macular and optic nerve diseases.

show abstract

Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Macular thickness reduction in eyes with unilateral optic atrophy detected with optical coherence tomography

Kusuhara

Nakamura

Nagai-Kusuhara

et al. 2005

Eye

View full text Add to dashboard Cite

show abstract

“…2 In this case, no radiological evidence existed of direct optic nerve injury. The end result of RNFL loss suggests a common feature in both direct and indirect traumatic optic neuropathy consisting of cell death and neuronal atrophy.…”

mentioning

confidence: 66%

A Survey of Ophthalmology Residents’ Attitudes Toward Pediatric Ophthalmology

Kothari

Mody

2011

J Pediatr Ophthalmol Strabismus

View full text Add to dashboard Cite

Reproducibility of Optical Coherence Tomography in Multiple Sclerosis

et al. 2008

View full text Add to dashboard Cite

Background: Optical coherence tomography (OCT) is a promising new method of quantifying axon thickness in the retinal nerve fiber layer (RNFL) that has been used predominantly by ophthalmologists to monitor glaucoma. Optical coherence tomography is being considered as a potential outcome measure in multiple sclerosis (MS) clinical trials, but no data exist on the reproducibility of this technique in MS centers. Objective: To determine the reproducibility of OCT measurement of mean RNFL thickness in the undilated eyes of healthy control subjects and patients with MS. Design: Prospective analysis of 4 healthy controls to determine interrater, intrarater, and longitudinal reproducibility. Cross-sectional analysis of 3 cohorts of patients with MS (n=396) and healthy controls (n = 153). Setting: Multiple sclerosis clinics at 3 academic medical centers. Patients or Other Participants: Healthy controls and patients with MS. Main Outcome Measure: Thickness of RNFL. Results: We found excellent agreement with respect to interrater (intraclass correlation [ICC], 0.89), intrarater (ICC, 0.98), and intervisit (ICC, 0.91) results. Mean RNFL thickness did not vary significantly among research centers for patients with MS (93, 92, and 90 µm) or among healthy controls (103, 105, and 104 µm) by site. Conclusions: We demonstrate that mean RNFL thickness can be reproducibly measured by trained technicians in an MS center using the OCT-3 model. The RNFL measures from cohorts of age-matched controls and patients with MS from 3 different research centers were remarkably similar.

show abstract

Axonal loss after traumatic optic neuropathy documented by optical coherence tomography

Cited by 93 publications

References 6 publications

Macular thickness reduction in eyes with unilateral optic atrophy detected with optical coherence tomography

Macular thickness reduction in eyes with unilateral optic atrophy detected with optical coherence tomography

A Survey of Ophthalmology Residents’ Attitudes Toward Pediatric Ophthalmology

Reproducibility of Optical Coherence Tomography in Multiple Sclerosis

Contact Info

Product

Resources

About