Axin1 Protects Colon Carcinogenesis by an Immune-Mediated Effect

Sanson, R D De; Lazzara, Silvia Luna; Cune, David; Pitasi, Caterina Luana; Trentesaux, Chantal; Fraudeau, Marie; Letourneur, Franck; Saintpierre, Benjamin; Gall, Morgane Le; Bossard, Pascale; Terris, Benoı̂t; Finetti, Pascal; Bertucci, François; Mamessier, Émilie; Romagnolo, Béatrice

doi:10.1016/j.jcmgh.2022.10.017

Cited by 8 publications

(6 citation statements)

References 59 publications

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“…Gene ontology analysis additionally supported these findings and highlighted many pathways; a big part of these pathways were related to immune system, infection, and caner. For example, RUNX3 signaling, 53 AXIN1 signaling, 54 noncanonical NF-kB signaling, 55 and TCR signaling 56 have been linked to immune-mediated pro-tumorigenic processes.…”

Section: Discussionmentioning

confidence: 99%

Manipulating macrophage polarization with nanoparticles to control metastatic behavior in heterotypic breast cancer micro-tissues via exosome signaling

Sungu,

Isik,

Güler

et al. 2024

Nanoscale

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Section: Discussionmentioning

confidence: 99%

Manipulating macrophage polarization with nanoparticles to control metastatic behavior in heterotypic breast cancer micro-tissues via exosome signaling

Sungu,

Isik,

Güler

et al. 2024

Nanoscale

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“…Sanson et al . 4 suggest that the function of Axin1 in the Wnt/β-catenin pathway can be entirely compensated for by Axin2, and vice versa. It remains a subject of debate as other studies describe otherwise.…”

Section: Axin1 Contributes To Intestinal Inflammation By Regulating T...mentioning

confidence: 96%

“… 11 A study utilizing RNA-seq has unveiled that Axin1 is linked to IFN-γ/STAT1/Th1 immune program through an unidentified mechanism; moreover, CRC patients exhibiting an Axin1-dependent gene expression signature tend to have a more favorable prognosis. 4 Guo et al . propose that Axin1 enhances the antiviral response to influenza by activating the JNK/c-Jun and Smad3 pathways, reducing virus replication, and increasing interferon (IFN) production.…”

Section: Axin1 Contributes To Intestinal Inflammation By Regulating T...mentioning

confidence: 99%

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Axin1‘s mystique in manipulating microbiome amidst colitis

Garrett,

Asada,

Sun

2023

Gut Microbes

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Classically, Axin1 is considered a regulator of Wnt/β-catenin signaling. However, Axin1’s roles in host-microbial interactions have been unknown. Our recent study has demonstrated that deletion of intestinal epithelial Axin1 in epithelial cells and Paneth cells protects the host against colitis by enhancing Akkermansia muciniphila . Loss of intestinal epithelial or Paneth cell Axin1 results in increased Wnt/β-catenin signaling, proliferation, and cell migration. This is associated with morphologically altered goblet and Paneth cells, including increased Muc2 and decreased lysozyme. Axin1 deletion specifically enriched Akkermansia muciniphila . Akkermansia muciniphila in Axin1 knockout mice is the driver of protection against DSS-induced inflammation. Here, we feature several significant conceptual changes, such as differences between Axin1 and Axin2, Axin1 in innate immunity and microbial homeostasis, and Axin1 reduction of Akkermansia muciniphila . We discuss an important trend in the field related to Paneth cells and tissue-specific Axin1 manipulation of microbiome in health and inflammation.

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“…7 , highlights significant tissue-specific variations, particularly within complexes composed of AXIN1 or AXIN2. Notably, in the mouse small intestine and colon, AXIN1 deficiency does not impede intestinal differentiation, as AXIN2 can effectively compensate for the loss of AXIN1, leading to the downregulation of WNT/β-catenin activity [ 189 ]. However, the mutation data suggests that AXIN1 and CTNNB1 play more pivotal roles in the liver.…”

Section: Introductionmentioning

confidence: 99%

The scaffold protein AXIN1: gene ontology, signal network, and physiological function

Qiu,

Sun,

Ning

et al. 2024

Cell Commun Signal

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AXIN1, has been initially identified as a prominent antagonist within the WNT/β-catenin signaling pathway, and subsequently unveiled its integral involvement across a diverse spectrum of signaling cascades. These encompass the WNT/β-catenin, Hippo, TGFβ, AMPK, mTOR, MAPK, and antioxidant signaling pathways. The versatile engagement of AXIN1 underscores its pivotal role in the modulation of developmental biological signaling, maintenance of metabolic homeostasis, and coordination of cellular stress responses. The multifaceted functionalities of AXIN1 render it as a compelling candidate for targeted intervention in the realms of degenerative pathologies, systemic metabolic disorders, cancer therapeutics, and anti-aging strategies. This review provides an intricate exploration of the mechanisms governing mammalian AXIN1 gene expression and protein turnover since its initial discovery, while also elucidating its significance in the regulation of signaling pathways, tissue development, and carcinogenesis. Furthermore, we have introduced the innovative concept of the AXIN1-Associated Phosphokinase Complex (AAPC), where the scaffold protein AXIN1 assumes a pivotal role in orchestrating site-specific phosphorylation modifications through interactions with various phosphokinases and their respective substrates.

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Axin1 Protects Colon Carcinogenesis by an Immune-Mediated Effect

Cited by 8 publications

References 59 publications

Manipulating macrophage polarization with nanoparticles to control metastatic behavior in heterotypic breast cancer micro-tissues via exosome signaling

Manipulating macrophage polarization with nanoparticles to control metastatic behavior in heterotypic breast cancer micro-tissues via exosome signaling

Axin1‘s mystique in manipulating microbiome amidst colitis

The scaffold protein AXIN1: gene ontology, signal network, and physiological function

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