Axillary Treatment in Conservative Management of Operable Breast Cancer: Dissection or Radiotherapy? Results of a Randomized Study With 15 Years of Follow-Up

Louis-Sylvestre, Christine; Clough, Krishna B.; Asselain, Bernard; Vilcoq, Jacques R.; Salmon, Rémy; Campana, F.; Fourquet, A.

doi:10.1200/jco.2004.12.108

Cited by 208 publications

(136 citation statements)

References 15 publications

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“…There is some evidence to support the management of women who are clinically node negative with axillary radiotherapy only. A study with 15 years of follow-up has found no difference in survival between clinically node negative women with early breast cancer managed with ALND or axillary radiotherapy, although a slightly higher rate of axillary recurrence was noted [72]. However this may be an equitable solution, in view of the fact that MM are likely to represent a lower risk of local and distant failure than macrometastasis and women could be spared the morbidity of ALND.…”

Section: Discussionmentioning

confidence: 93%

The clinical significance of sentinel lymph node micrometastasis in breast cancer

Patani

Mokbel

2008

Breast Cancer Res Treat

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Section: Discussionmentioning

confidence: 93%

The clinical significance of sentinel lymph node micrometastasis in breast cancer

Patani

Mokbel

2008

Breast Cancer Res Treat

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“…In SLND studies, including the current study, the axillary lymph node recurrence rate after SLND is comparable to or less than the axillary lymph node recurrence rate of 1-2.5% after ALND for early-stage breast carcinoma at a median interval of 2.6 years between axillary surgery and disease recurrence. [17][18][19][20] The prevalence of axillary metastases is highly variable in patients with clinically negative lymph nodes and can be predicted based on the primary tumor size, ranging from 12.3% for T1a tumors, 18.5% for T1b tumors, 30.4% for T1c tumors, 48% for T2 tumors to 77.3% for T3 tumors. 21 The risk of axillary lymph node recurrence also varies accordingly.…”

Section: Discussionmentioning

confidence: 99%

Axillary disease recurrence after sentinel lymph node dissection for breast carcinoma

Swenson

Mahipal

Nissen

et al. 2005

Cancer

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BACKGROUNDSurgical recommendation for early‐stage breast carcinoma includes removal of the primary breast tumor and evaluation of the axillary lymph nodes on the ipsilateral side. Sentinel lymph node dissection (SLND) is increasingly being used to evaluate axillary lymph nodes in clinically lymph node negative patients as an alternative to axillary lymph node dissection (ALND). Results from SLND are highly predictive of metastatic involvement in the axilla, and are associated with fewer side effects. However, the greatest concern with SLND alone is the potential for a higher rate of axillary lymph node recurrence. The purpose of the current study was to review data collected on 700 consecutive patients with early‐stage breast carcinoma who underwent SLND without concomitant ALND.METHODSA retrospective study was conducted using the oncology registry at Park Nicollet Health Services (Minneapolis, MN). Consecutive breast carcinoma cases with SLND only for axillary surgery, from January 28, 1999 to December 31, 2003, were included in the study. During this period, 700 patients with breast carcinoma were identified who had SLND alone. Fifty‐two patients were excluded from the analysis because they had ductal carcinoma in situ.RESULTSWith a median follow‐up of 33 months (range, 2‐73 mos), axillary lymph node recurrence occurred in 4 of 647 (0.62%) patients overall. In these 4 patients, the axillary lymph node recurrences were isolated to the axillary lymph nodes and amenable to surgery.CONCLUSIONSData from the current study showed that axillary lymph node recurrence after SLND occurred very infrequently in early‐stage breast carcinoma, and these results were comparable to other studies. Cancer 2005. © 2005 American Cancer Society.

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“…106 In these patients, excision of all regional lymph nodes from the axilla compared with excision of sentinel lymph node alone did not result in additional benefit. 107,108 Therefore, it was concluded that removal of the sentinel lymph node might be sufficient and more extensive removal of axillary nodes was not recommended in patients without sentinel lymph node metastasis.…”

Section: The Role Of Vegfs In Lymphangiogenesismentioning

confidence: 99%

Interaction of tumor cells and lymphatic vessels in cancer progression

2011

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Axillary Treatment in Conservative Management of Operable Breast Cancer: Dissection or Radiotherapy? Results of a Randomized Study With 15 Years of Follow-Up

Abstract: In early breast cancers with clinically uninvolved lymph nodes, our findings show that long-term survival does not differ after axillary radiotherapy and axillary dissection. The only difference is a better axillary control in the group with axillary dissection.

Cited by 208 publications

References 15 publications

The clinical significance of sentinel lymph node micrometastasis in breast cancer

The clinical significance of sentinel lymph node micrometastasis in breast cancer

Axillary disease recurrence after sentinel lymph node dissection for breast carcinoma

Interaction of tumor cells and lymphatic vessels in cancer progression

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