Awareness of major cardiovascular risk factors and its relationship with markers of vascular aging: Data from the Brisighella Heart Study

Presta, Vivianne; Cicero, Arrigo Francesco Giuseppe; D’Addato, Sergio; Borghi, Claudio; Fogacci, Federica; Giovannini, Marina; Rizzoli, Elisabetta; Ventura, Fulvio; Coppola, Paolo Elia; Piani, Federica; Soldati, Mario; Iamino, Ilaria Ricci; Palmisano, Silvia; Landolfo, Matteo; Rosticci, Martina; Derosa, Giuseppe; Bacchelli, Stefano; Borghi, Claudio

doi:10.1016/j.numecd.2020.03.005

Cited by 25 publications

(18 citation statements)

References 28 publications

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“…It is possible that the lower level of awareness could be explained by the absence of atherosclerotic cardiovascular disease in the BHS. In that study, 19.5% and 22.5% individuals had abnormal high serum values of cholesterol and triglycerides without their awareness 14 . The authors concluded that the lack of awareness of hypercholesterolemia and hypertension is frequent and it is associated with higher arterial stiffness.…”

Section: Discussionmentioning

confidence: 84%

“…The authors concluded that the lack of awareness of hypercholesterolemia and hypertension is frequent and it is associated with higher arterial stiffness. It will be important to determine the level of awareness of dyslipidemia in the general population since this is a common modifiable risk factor associated with CVDs 14 . In general, to increase the awareness of HTN and other modifiable risk factors, it will be important to improve the levels of education, income, and health care, including ample screening programs, particularly in the rural areas.…”

Section: Discussionmentioning

confidence: 99%

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Low levels of awareness, treatment, and control of hypertension in Andean communities of Ecuador

Félix

Baldeón

Zertuche

et al. 2020

J of Clinical Hypertension

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Cardiovascular diseases (CVD) are the principal cause of mortality in low-medium-income countries (LMIC). 1 Globally, hypertension (HTN) is the main modifiable risk factor for CVD with a population attributable risk of 32.5% (42.7% for coronary heart disease, 38.9% for stroke, and 21.9% for heart failure). 2 Currently, HTN is common in LMIC where the percentages of awareness, treatment, and control of the disease are very low, 3 particularly in Latin America. 4 Few population studies on HTN prevalence have been carried out in Ecuador, and however, it is not known the rates of awareness, treatment, and control of HTA. 5 Thus, the aim of the present study was to determine the prevalence, awareness, treatment, and control of HTA and the association with socioeconomic , nutritional, and lifestyle habits in urban and rural communities of Pichincha province in Ecuador, that are included in the Prospective Urban and Rural Epidemiology (PURE) study. 4 2 | ME THODS 2.1 | Study design and participants Ecuadorian participants (n = 2020) are part of the international cohort of the PURE study, coordinated by the Population Health

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Low levels of awareness, treatment, and control of hypertension in Andean communities of Ecuador

Félix

Baldeón

Zertuche

et al. 2020

J of Clinical Hypertension

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“…1, Table 3). The lack of knowledge about preventable risk factors could hinder the action plans on reducing CVDs [71].…”

Section: Discussionmentioning

confidence: 99%

Pathways leading to prevention of fatal and non-fatal cardiovascular disease: An interaction model on 15 years population-based cohort study

et al. 2020

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Background: A comprehensive study on the interaction of cardiovascular disease (CVD) risk factors is critical to prevent cardiovascular events. The main focus of this study is thus to understand direct and indirect relationships between different CVD risk factors. Methods: A longitudinal data on adults aged ≥35 years, who were free of CVD at baseline, were used in this study. The endpoints were CVD events, whereas their measurements were demographic, lifestyle components, socioeconomics, anthropometric measures, laboratory findings, quality of life status, and psychological factors. A Bayesian structural equation modelling was used to determine the relationships among 21 relevant factors associated with total CVD, stroke, acute coronary syndrome (ACS), and fatal CVDs. Results: In this study, a total of 3161 individuals with complete information were involved in the study. A total of 407 CVD events, with an average age of 54.77(10.66) years, occurred during follow-up. The causal associations between six latent variables were identified in the causal network for fatal and non-fatal CVDs. Lipid profile, with the coefficient of 0.26 (0.01), influenced the occurrence of CVD events as the most critical factor, while it was indirectly mediated through risky behaviours and comorbidities. Lipid profile at baseline was influenced by a wide range of other protective factors, such as quality of life and healthy lifestyle components. Conclusions: Analysing a causal network of risk factors revealed the flow of information in direct and indirect paths. It also determined predictors and demonstrated the utility of integrating multi-factor data in a complex framework to identify novel preventable pathways to reduce the risk of CVDs.

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“…All subjects were asked to do an overnight fast Venous blood samples were obtained from all study participants and analyzed by Biaojia Biotechnology Laboratory in Shenzhen, China. Lipids (including total cholesterol (TC, mmol/L), triglycerides (TG, mmol/L), highdensity lipoprotein-cholesterol (HDL-C, mmol/L), lowdensity lipoprotein cholesterol (LDL-C, mmol/L)), 12,13 estimated glomerular filtration rate (eGFR, mL/min/ 1.73 m 2 ), fasting blood glucose (FBG, mmol/L) and homocysteine (Hcy, μmol/L) were measured using automatic clinical analyzers (Beckman Coulter, USA) and the laboratory staff were blind to the research protocol.…”

Section: Laboratory Biochemical Examinationmentioning

confidence: 99%

U-Shaped Association of Body Mass Index with the Risk of Peripheral Arterial Disease in Chinese Hypertensive Population

Li¹,

Yu²,

Zhou³

et al. 2021

IJGM

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Background: High body mass index (BMI) is a well-recognized risk factor for cardiovascular diseases. But its role in peripheral artery disease (PAD) remains perplexing. Our study aims to evaluate the association of BMI with PAD in the Chinese hypertensive population. Methods: This is a cross-sectional study with enrollment data from the Chinese H-type Hypertension Registry.10896 hypertensive patients aged ≥18 years were included in the final analysis. Results: The prevalence of PAD diagnosed by ABI in this study was 3.2% (n=351). A U-shaped association between BMI and PAD was found. Per SD increment (3.6 kg/m 2 ) on the left side of the BMI threshold (BMI < 25.7 kg/m 2 ) was associated with a 27% decrease in the adjusted risk of PAD [OR, 0.73; 95% confidence interval (CI) 0.60, 0.89; P=0.002]; BMI was significantly positively associated with the risk of PAD (OR, 1.52; 95% CI 1.52, 1.93; P=0.001) in those with BMI ≥25.7 kg/m 2 . Conclusion: In summary, a U-shaped association between BMI and the risk of PAD in the Chinese hypertensive population was found. BMI with the lowest risk of PAD was estimated to be 25.7 kg/m 2 .

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Awareness of major cardiovascular risk factors and its relationship with markers of vascular aging: Data from the Brisighella Heart Study

Cited by 25 publications

References 28 publications

Low levels of awareness, treatment, and control of hypertension in Andean communities of Ecuador

Low levels of awareness, treatment, and control of hypertension in Andean communities of Ecuador

Pathways leading to prevention of fatal and non-fatal cardiovascular disease: An interaction model on 15 years population-based cohort study

U-Shaped Association of Body Mass Index with the Risk of Peripheral Arterial Disease in Chinese Hypertensive Population

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