U-Shaped Association of Body Mass Index with the Risk of Peripheral Arterial Disease in Chinese Hypertensive Population

Abstract

Background: High body mass index (BMI) is a well-recognized risk factor for cardiovascular diseases. But its role in peripheral artery disease (PAD) remains perplexing. Our study aims to evaluate the association of BMI with PAD in the Chinese hypertensive population. Methods: This is a cross-sectional study with enrollment data from the Chinese H-type Hypertension Registry.10896 hypertensive patients aged ≥18 years were included in the final analysis. Results: The prevalence of PAD diagnosed by ABI in this study was 3.2% (n=351). A U-shaped association between BMI and PAD was found. Per SD increment (3.6 kg/m 2 ) on the left side of the BMI threshold (BMI < 25.7 kg/m 2 ) was associated with a 27% decrease in the adjusted risk of PAD [OR, 0.73; 95% confidence interval (CI) 0.60, 0.89; P=0.002]; BMI was significantly positively associated with the risk of PAD (OR, 1.52; 95% CI 1.52, 1.93; P=0.001) in those with BMI ≥25.7 kg/m 2 . Conclusion: In summary, a U-shaped association between BMI and the risk of PAD in the Chinese hypertensive population was found. BMI with the lowest risk of PAD was estimated to be 25.7 kg/m 2 .

Associations Between the Metabolic Score for Insulin Resistance Index and the Risk of Type 2 Diabetes Mellitus Among Non-Obese Adults: Insights from a Population-Based Cohort Study

“…We incorporated all initial variables into the ordinary least squares (OLS) model and calculated the variance inflation factor (VIF) of each variable to test for multicollinearity. 29 Variables with VIF>5 were considered to have serious multicollinearity and cannot be included in the multiple regression model. A Cox proportional-hazard regression model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incidents of T2DM by quartiles of the METS-IR index, with the lowest quartile as the reference.…”

Predictive Effect of Triglyceride-Glucose Index on Adverse Prognostic Events in Patients with Type 2 Diabetes Mellitus and Ischemic Cardiomyopathy

“… 31 High BMI and LDL-C are known as risk factors for CVD worldwide. 32 , 33 As a result, early detection of high-risk individuals and timely implementation of treatment plans based on the TyG index improve the prognosis of these patients. In addition, it aids in the screening of high-risk patients for early intervention.…”

Association Between Lipid Accumulation Product and Cognitive Function in Hypertensive Patients With Normal Weight: Insight From the China H-type Hypertension Registry Study

“…Briefly, the study was a large-scale, realworld observational registry study that aimed to create a national registry of patients with H-type hypertension, investigate the prevalence and control of H-type hypertension in China, and explore related factors that would affect disease prognosis. Details of the methodology of this study had been published elsewhere (18). The enrolled participants fulfilled the following criteria: (1) age ≥ 18 years and (2) hypertension defined as systolic blood pressure (SBP) ≥ 140 mm Hg and/or diastolic blood pressure (DBP) ≥ 90 mm Hg, self-reported diagnosis of hypertension previously, or receiving antihypertensive medication at baseline.…”