Avocado/soybean unsaponifiables: a novel regulator of cutaneous wound healing, modelling and remodelling

Abstract

We investigated the effects of avocado/soybean unsaponifiables (ASU) on the healing response of cutaneous wound defect in rats. Sixty male rats were randomly divided into three groups including control, vehicle and treatment (n = 20 in each group). A 2 × 2 cm(2) wound defect was made on the dorsum. The control, vehicle and treatment groups were treated daily with topical application of saline, cream and cream/ASU for 10 days, respectively. The wounds were monitored daily. The animals were euthanised at 10, 20 and 30 days post injury (D). The dry matter, hydroxyproline, collagen, n-acetyl glucosamine (NAGLA) and n-acetyl galactosamine (NAGAA) contents of the skin samples were measured and the histopathological and biomechanical characteristics of the samples were investigated. Statistics of P < 0·05 was considered significant. Treatment significantly increased tissue glycosaminoglycans and collagen contents at various stages of wound healing compared to controls. Treatment modulated inflammation, improved fibroplasia and produced high amounts of scar tissue at short term. At long term, treatment reduced the scar tissue size and increased the quality and rate of wound contraction and reepithelisation compared to controls. The treated lesions were more cosmetically pleasing and had significantly higher biomechanical characteristics than controls. ASU was effective in rat wound healing.

Accelerative effect of topical Zataria multiflora essential oil against infected wound model by modulating inflammation, angiogenesis, and collagen biosynthesis

“…It was reported that IGF-1 increases fibroblast cells in in vitro assessment (Lisa et al 2011). Improving cellular proliferation and differentiation are essential for shortening the healing time (Oryan et al 2015;Karimzadeh and Farahpour 2017). Proliferative effect of ZMEO is partly owing to its antioxidant activity.…”

Topical application of Cinnamomum hydroethanolic extract improves wound healing by enhancing re-epithelialization and keratin biosynthesis in streptozotocin-induced diabetic mice

“…Rapid cellular proliferation and differentiation are necessary in shortening the healing time (Oryan et al. 2015; Karimzadeh and Farahpour 2017). Controlled apoptosis and up-regulated revascularization are associated with the increase in collagen deposition which accelerates the healing process (Wu and Chen 2014; Manzuoerh et al.…”

Avocado–Soybean Unsaponifiables: A Panoply of Potentialities to Be Exploited

“…The study found that treatment (cream plus ASU) produced a significantly higher level of tissue glycosaminoglycan and collagen contents compared to controls. It was also reported that the treatment had a modulating effect on inflammation, improved fibroplasia and provided higher amounts of scar tissue; so, it was concluded that ASU is a promising agent in wound healing [115].…”