Avian oncogenesis induced by lymphoproliferative disease virus: A neglected or emerging retroviral pathogen?

Allison, Andrew B.; Keel, M. Kevin; Philips, Jamie E.; Cartoceti, Andrew N.; Munk, Brandon; Nemeth, Nicole M.; Welsh, Trista; Thomas, Jesse M.; Crum, James M.; Lichtenwalner, Anne; Fadly, A. M.; Zavala, Guillermo; Holmes, Edward C.; Brown, Justin D.

doi:10.1016/j.virol.2013.11.037

Cited by 32 publications

(66 citation statements)

References 41 publications

(54 reference statements)

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“…Lymphoproliferative disease (LD), caused by an exogenous retrovirus called lymphoproliferative disease virus (LPDV), occurs in domestic turkeys in Israel and several countries in Europe, and in wild turkeys in North America (Allison et al, 2014;Hayes and Langheinrich, 1992;Thomas et al, 2015). LD is characterized by multifocal to coalescing tan, raised, firm skin nodules composed of pleomorphic lymphoid cells admixed with plasma cells in unfeathered skin on the head or legs (Fig.…”

Section: Rna Virusesmentioning

confidence: 99%

Galliformes and Columbiformes

Crespo

França

Fenton

et al. 2018

Pathology of Wildlife and Zoo Animals

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Section: Rna Virusesmentioning

confidence: 99%

Galliformes and Columbiformes

Crespo

França

Fenton

et al. 2018

Pathology of Wildlife and Zoo Animals

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“…Likewise, we could not obtain any amplified fragments on our studied DNA template neither in spleen nor in liver of both studied peafowls. Similarly, DNA was extracted for LPDV detection by PCR using specific primers (Allison et al, 2014). All of the studied samples were negative for LPDV (data not shown).In conclusion, we could not find any MDV and/ or LPDV contamination in the studied samples.…”

Section: Pcr Analysismentioning

confidence: 72%

“…Extracted DNA was used as a template with specific primers of MDV, REV, ALV and LPDV viruses for the PCR as previously described (Smith Khordadmehr M, Firouzamandi M, Zehtab-Najafi M, Shahbazi R Naturally Occurring Co-infection of Avian Leukosis Virus (subgroups A-E) and Reticuloendotheliosis Virus in Green Peafowls (Pavo muticus) Cao et al, 2013;Allison et al, 2014). Sequences of the primers used, including MdCv/ pp38, REV long terminal repeat (LTR), ALV (H5/H7; H5/ AD1) and LPDV, are shown in Table 1.…”

Section: Molecular Diagnosismentioning

confidence: 99%

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Naturally Occurring Co-infection of Avian Leukosis Virus (subgroups A-E) and Reticuloendotheliosis Virus in Green Peafowls (Pavo muticus)

Khordadmehr

Firouzamandi

Zehtab-Najafi

et al. 2017

Rev. Bras. Cienc. Avic.

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Most of the neoplastic diseases affecting poultry have a viral etiology, such as Marek's disease, avian leukosis/sarcoma and reticuloendotheliosis. In the present paper, histopathology and molecular methods were performed, in addition of necropsy and gross morphology evaluation, for the differential diagnosis of these diseases in two green peafowls (Pavo muticus). The affected birds showed nonspecific signs, such as depression, anorexia, and diarrhea. At necropsy, diffuse enlargement by several times the normal size of the liver and the spleen was observed. In one of the birds, the liver presented white to grayish discoloration was present, and focal and nodular growths in the other bird. Grossly, the other visceral organs and the peripheral nerves were normal. Microscopically, most of the tumor cells were large and uniform with pleomorphic nuclei. The PCR analysis for Marek's disease virus (MDV), avian leukosis virus (ALV), lymphoproliferative disease virus (LPDV), and reticuloendotheliosis virus (REV)based on their specific sequences showed the presence of ALV subgroups A-E and REV. According to these results, definitive diagnosis was co-infection of ALV and REV in naturally-infected green peafowls.

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“…Lymphoproliferative disease virus (LPDV), an oncogenic avian retrovirus has been reported in domestic turkeys in Europe and Israel for decades. Allison et al (2014) described emerging LPDV in wild birds and genetic diversity and evolution of LPDV in the United States.…”

Section: Classical Methods For Study Of Virus Diversitymentioning

confidence: 99%

Next generation sequencing technologies: Tool to study avian virus diversity

Kapgate¹,

Barbuddhe²,

Kumanan³

2015

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Summary. -Increased globalisation, climatic changes and wildlife-livestock interface led to emergence of novel viral pathogens or zoonoses that have become serious concern to avian, animal and human health. High biodiversity and bird migration facilitate spread of the pathogen and provide reservoirs for emerging infectious diseases. Current classical diagnostic methods designed to be virus-specific or aim to be limited to group of viral agents, hinder identifying of novel viruses or viral variants. Recently developed approaches of next-generation sequencing (NGS) provide culture-independent methods that are useful for understanding viral diversity and discovery of novel virus, thereby enabling a better diagnosis and disease control. This review discusses the different possible steps of a NGS study utilizing sequence-independent amplification, high-throughput sequencing and bioinformatics approaches to identify novel avian viruses and their diversity. NGS lead to the identification of a wide range of new viruses such as picobirnavirus, picornavirus, orthoreovirus and avian gamma coronavirus associated with fulminating disease in guinea fowl and is also used in describing viral diversity among avian species. The review also briefly discusses areas of viral-host interaction and disease associated causalities with newly identified avian viruses.

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Avian oncogenesis induced by lymphoproliferative disease virus: A neglected or emerging retroviral pathogen?

Cited by 32 publications

References 41 publications

Galliformes and Columbiformes

Galliformes and Columbiformes

Naturally Occurring Co-infection of Avian Leukosis Virus (subgroups A-E) and Reticuloendotheliosis Virus in Green Peafowls (Pavo muticus)

Next generation sequencing technologies: Tool to study avian virus diversity

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