Avian Influenza A(H7N2) Virus in Human Exposed to Sick Cats, New York, USA, 2016

Marinova‐Petkova, Atanaska; Laplante, Jen; Jang, Yunho; Lynch, Brian; Zanders, Natosha; Rodriguez, Marisela R.; Jones, Joyce; Thor, Sharmi; Hodges, Erin; Cruz, Juan A. De La; Belser, Jessica A.; Yang, Hua; Carney, P.J.; Shu, Bo; Berman, LaShondra; Stark, Thomas; Barnes, John; Havers, Fiona; Yang, Patrick; Trock, Susan C.; Fry, Alicia M.; Gubareva, Larisa V.; Bresee, Joseph S.; Stevens, James; Daskalakis, Demetre; Liu, Dakai; Lee, Christopher T.; Torchetti, Mia Kim; Newbury, Sandra; Cigel, Francine; Toohey-Kurth, Kathy; George, Kirsten St.; Wentworth, David E.; Lindstrom, Stephen; Davis, C. Todd

doi:10.3201/eid2312.170798

Cited by 45 publications

(34 citation statements)

References 12 publications

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“…Unlike the H7N2, H7N3 and H7N7 mainly caused only mild symptoms [10][11][12][13], the H7N4 virus led to a severe human infection, as most of the reported H7N9 patients [22]. However, distinct from the H7N9, all gene segments of the H7N4 were from influenza viruses of wild birds, where reassortments might occur.…”

Section: Resultsmentioning

confidence: 99%

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Severe human infection with a novel avian-origin influenza A(H7N4) virus

Xiang

Cui

Chen³

et al. 2018

Science Bulletin

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a b s t r a c tHuman infections with influenza H7 subtypes, such as H7N9, have raised concerns worldwide. Here, we report a human infection with a novel influenza A(H7N4) virus. A 68 years-old woman with cardiovascular and cholecystic comorbidities developed rapidly progressed pneumonia with influenza-like-illness as initial symptom, recovered after 23 days-hospitalization including 8 days in ICU. Laboratory indicators for liver and blood coagulation dysfunction were observed. Oseltamivir phosphate, glucocorticoids and antibiotics were jointly implemented, with nasal catheterization of oxygen inhalation for this patient. We obtained the medical records and collected serial respiratory and blood specimens from her. We collected throat, cloacal and/or feces samples of poultry and wild birds from the patient's backyard, neighborhood, local live poultry markets (LPMs) and the nearest lake. All close contacts of the patient were followed up and sampled with throat swabs and sera. Influenza viruses and other respiratory pathogens were tested by real-time RT-PCR, viral culturing and/or sequencing for human respiratory and bird samples. Micro-neutralizing assay was performed for sera. A novel reassortant wild bird-origin H7N4 virus is identified from the patient and her backyard poultry (chickens and ducks) by sequencing, which is distinct from previously-reported avian H7N4 and H7N9 viruses. At least four folds increase of neutralizing antibodies to H7N4 was detected in her convalescent sera. No samples from close contacts, wild birds or other poultry were tested positive for H7N4 by real-time RT-PCR.

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Section: Resultsmentioning

confidence: 99%

“…The H7 subtype HA gene has been found in combination with all nine NA subtype genes [9]. Other influenza A subtype H7 viruses, such as H7N2, H7N3 and H7N7, were documented being capable of infecting human as well [10][11][12][13], but usually selflimiting.…”

Section: Introductionmentioning

confidence: 99%

Severe human infection with a novel avian-origin influenza A(H7N4) virus

Xiang

Cui

Chen³

et al. 2018

Science Bulletin

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“…Even though this seems an isolated event of AIV trespassing the human host range, it certainly reminds us the plasticity of the IAV to cross the species barrier. 98 …”

mentioning

confidence: 99%

Sialic acid receptors: focus on their role in influenza infection

Ayora-Talavera¹

2018

JRLCR

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“…The cats were subsequently moved into a separate facility to facilitate control efforts, but because of the large number of cats in the shelter it took a number of weeks to bring the outbreak under control (Blachere et al 2018). A human infection was observed in one of the veterinarians involved in the control program at the shelter, in whom virus was sampled from the respiratory tract, but no clinical disease was observed (Belser et al 2017;Marinova-Petkova et al 2017). Sequence and phylogenetic analysis showed that the virus closely matched circulating avian H7N2 in the New York area over the preceding decade (Fig.…”

Section: Outbreak Of H7n2 Influenza Avian Influenza Virus In Cats Inmentioning

confidence: 99%