Avian cryptosporidiosis and its zoonotic significance in Asia

Zaheer, Tean; Imran, Muhammad; Abbas, Rao Zahid; Zaheer, Iqra; Malik, M. A.

doi:10.1080/00439339.2020.1866961

Cited by 5 publications

(7 citation statements)

References 87 publications

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“…Birds may act as a source of infection as well as a vector by shedding oocysts into the environment. Foreign travel is a key element in the spread of sickness, and the export of birds from countries where the disease is endemic also helps (Zaheer et al, 2021).…”

Section: Primers Of Pcrmentioning

confidence: 99%

Traditional and Molecular Detection of Cryptosporidium Parasite in Quails (Coturnix coturnix) in Baghdad Province, Iraq

Yahya¹,

Al-Zubaidi²

2023

AAVS

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Section: Primers Of Pcrmentioning

confidence: 99%

Traditional and Molecular Detection of Cryptosporidium Parasite in Quails (Coturnix coturnix) in Baghdad Province, Iraq

Yahya¹,

Al-Zubaidi²

2023

AAVS

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“…Cryptosporidium can be transmitted in many ways, but the most common way to spread the parasite is through water (drinking and recreational water). The parasite’s outer shell protects it from chlorine disinfection and allows it to exist outside the body for long periods ( Zaheer et al., 2021 ). Cryptosporidium parvum can stop an infant’s development suddenly and can be fatal in immunocompromised people.…”

Section: Functional Role Of Dubs Indifferent Parasitesmentioning

confidence: 99%

The emerging role of Deubiquitinases (DUBs) in parasites: A foresight review

Kumar

Mandal

et al. 2022

Front. Cell. Infect. Microbiol.

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Before the discovery of the proteasome complex, the lysosomes with acidic proteases and caspases in apoptotic pathways were thought to be the only pathways for the degradation of damaged, unfolded, and aged proteins. However, the discovery of 26S and 20S proteasome complexes in eukaryotes and microbes, respectively, established that the degradation of most proteins is a highly regulated ATP-dependent pathway that is significantly conserved across each domain of life. The proteasome is part of the ubiquitin-proteasome system (UPS), where the covalent tagging of a small molecule called ubiquitin (Ub) on the proteins marks its proteasomal degradation. The type and chain length of ubiquitination further determine whether a protein is designated for further roles in multi-cellular processes like DNA repair, trafficking, signal transduction, etc., or whether it will be degraded by the proteasome to recycle the peptides and amino acids. Deubiquitination, on the contrary, is the removal of ubiquitin from its substrate molecule or the conversion of polyubiquitin chains into monoubiquitin as a precursor to ubiquitin. Therefore, deubiquitylating enzymes (DUBs) can maintain the dynamic state of cellular ubiquitination by releasing conjugated ubiquitin from proteins and controlling many cellular pathways that are essential for their survival. Many DUBs are well characterized in the human system with potential drug targets in different cancers. Although, proteasome complex and UPS of parasites, like plasmodium and leishmania, were recently coined as multi-stage drug targets the role of DUBs is completely unexplored even though structural domains and functions of many of these parasite DUBs are conserved having high similarity even with its eukaryotic counterpart. This review summarizes the identification & characterization of different parasite DUBs based on in silico and a few functional studies among different phylogenetic classes of parasites including Metazoan (Schistosoma, Trichinella), Apicomplexan protozoans (Plasmodium, Toxoplasma, Eimeria, Cryptosporidium), Kinetoplastidie (Leishmania, Trypanosoma) and Microsporidia (Nosema). The identification of different homologs of parasite DUBs with structurally similar domains with eukaryotes, and the role of these DUBs alone or in combination with the 20S proteosome complex in regulating the parasite survival/death is further elaborated. We propose that small molecules/inhibitors of human DUBs can be potential antiparasitic agents due to their significant structural conservation.

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“…Various types of Cryptosporidiosis such respiratory, ocular, renal and intestinal have been observed based on clinical signs and symptoms. Respiratory Cryptosporidiosis is more common in domestic poultry birds than intestinal Cryptosporidiosis except turkey (Zaheer et al 2021). C. meleagridis, C. baileyi and C. galli are the important causative agents in avian Cryptosporidiosis that infect chickens, turkeys, quails, ostriches, Passeriformes and Psittaciformes (Novaes et al 2018;Kabir et al 2020).…”

Section: Avian Cryptosporidiosismentioning

confidence: 99%

“…From 2009 to 2017, the number of human Cryptosporidiosis outbreaks in the United States increased at an annual rate of 12.8%. In under-developed countries, the situation could be even worse (Zaheer et al 2021). Foodborne diseases cost the global economy by $15.5 billions per year due to infections caused by enteric microorganisms.…”

Section: Introductionmentioning

confidence: 99%

Cryptosporidiosis

2021

Int J Vet Sci

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Avian cryptosporidiosis and its zoonotic significance in Asia

Cited by 5 publications

References 87 publications

Traditional and Molecular Detection of Cryptosporidium Parasite in Quails (Coturnix coturnix) in Baghdad Province, Iraq

Traditional and Molecular Detection of Cryptosporidium Parasite in Quails (Coturnix coturnix) in Baghdad Province, Iraq

The emerging role of Deubiquitinases (DUBs) in parasites: A foresight review

Cryptosporidiosis

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