Avian Antibodies (IgY)-A New Weapon against Antibiotic Resistance

Kollberg, H

doi:10.4172/2327-5073.1000304

Cited by 2 publications

(1 citation statement)

References 8 publications

(6 reference statements)

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“…Inclusion of stabilizing agents (e.g., glycerol or glycine, sucrose, maltose) conferred comparatively more protection against high pressure, acid pH and thermal denaturation of IgY. Longterm storage (20 years) of IgY is reported without any remarkable loss of antibody titer at +4°C ( Kollberg et al , 2015 ). IgY shown resistant against trypsin and chymotrypsin inactivation and retained 40% immunologic activity after 8 h of digestion in vitro in the presence of these pancreatic enzymes ( Hatta et al , 1993 ).…”

Section: Intrinsic Properties Of Igy and Its Application To Heterologmentioning

confidence: 99%

Chicken Egg Yolk Antibodies (IgY) for Prophylaxis and Treatment of Rotavirus Diarrhea in Human and Animal Neonates: A Concise Review

Thu¹,

Myat²,

Win³

et al. 2017

Korean Journal for Food Science of Animal Resources

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The rotavirus-induced diarrhea of human and animal neonates is a major public health concern worldwide. Until recently, no effective therapy is available to specifically inactivate the rotavirion particles within the gut. Passive immunotherapy by oral administration of chicken egg yolk antibody (IgY) has emerged of late as a fresh alternative strategy to control infectious diseases of the alimentary tract and has been applied in the treatment of diarrhea due to rotavirus infection. The purpose of this concise review is to evaluate evidence on the properties and performance of anti-rotavirus immunoglobulin Y (IgY) for prevention and treatment of rotavirus diarrhea in human and animal neonates. A survey of relevant anti-rotavirus IgY basic studies and clinical trials among neonatal animals (since 1994-2015) and humans (since 1982-2015) have been reviewed and briefly summarized. Our analysis of a number of rotavirus investigations involving animal and human clinical trials revealed that anti-rotavirus IgY significantly reduced the severity of clinical manifestation of diarrhea among IgY-treated subjects relative to a corresponding control or placebo group. The accumulated information as a whole depicts oral IgY to be a safe and efficacious option for treatment of rotavirus diarrhea in neonates. There is however a clear need for more randomized, placebo controlled and double-blind trials with bigger sample size to further solidify and confirm claims of efficacy and safety in controlling diarrhea caused by rotavirus infection especially among human infants with health issues such as low birth weights or compromised immunity in whom it is most needed.

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Section: Intrinsic Properties Of Igy and Its Application To Heterologmentioning

confidence: 99%

Chicken Egg Yolk Antibodies (IgY) for Prophylaxis and Treatment of Rotavirus Diarrhea in Human and Animal Neonates: A Concise Review

Thu¹,

Myat²,

Win³

et al. 2017

Korean Journal for Food Science of Animal Resources

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show abstract

Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects

Uddin

Chakraborty

Khusro³

et al. 2021

Journal of Infection and Public Health

477

214

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Avian Antibodies (IgY)-A New Weapon against Antibiotic Resistance

Abstract: Alternatives to antibiotics for the treatment and prevention of infections are badly needed. Passive immune therapy with avian antibodies (immune globulin, IgY) from eggs of hens, that have been vaccinated with a specific microbe, is a real alternative.

Cited by 2 publications

References 8 publications

Chicken Egg Yolk Antibodies (IgY) for Prophylaxis and Treatment of Rotavirus Diarrhea in Human and Animal Neonates: A Concise Review

Chicken Egg Yolk Antibodies (IgY) for Prophylaxis and Treatment of Rotavirus Diarrhea in Human and Animal Neonates: A Concise Review

Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects

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