2017
DOI: 10.5851/kosfa.2017.37.1.1
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Abstract: The rotavirus-induced diarrhea of human and animal neonates is a major public health concern worldwide. Until recently, no effective therapy is available to specifically inactivate the rotavirion particles within the gut. Passive immunotherapy by oral administration of chicken egg yolk antibody (IgY) has emerged of late as a fresh alternative strategy to control infectious diseases of the alimentary tract and has been applied in the treatment of diarrhea due to rotavirus infection. The purpose of this concise … Show more

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Cited by 46 publications
(40 citation statements)
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“…IgYs cause agglutination of pathogens (virus, bacterial, fungal), leading to their immobilization, which facilitates their removal from the gut. 61…”
Section: Agglutinationmentioning
confidence: 99%
See 1 more Smart Citation
“…IgYs cause agglutination of pathogens (virus, bacterial, fungal), leading to their immobilization, which facilitates their removal from the gut. 61…”
Section: Agglutinationmentioning
confidence: 99%
“…Further, they can be stored for months in powder form at low moisture without the need for refrigeration, and they are cheaper and faster to produce than vaccines. 61 Use of IgY antibodies also has general advantages in the context of immunotherapy. Egg collection is pain-free and animal friendly, which is beneficial from the perspective of animal welfare.…”
Section: Advantages Of Passive Immunization With Igymentioning
confidence: 99%
“…Compared with the IgG from mammals, IgY is more stable (30,31), easy to collect (32), has a high yield (33) and does not react with rheumatoid factors, complement components or mammalian Fc receptors in human serum (34). At present, the application of IgY in the diagnosis and treatment of human diseases has become a research hotspot, particularly regarding infections caused by Helicobacter pylori (35), Vibrio cholerae (36) and other bacterial infections, as well as the infections by human rotavirus (37), severe acute respiratory syndrome coronavirus (38) and other viruses. IgY can also be used for the preparation of diagnostic antibodies for immunohistochemistry, ELISA (39), western blotting and other diagnostic techniques.…”
Section: Introductionmentioning
confidence: 99%
“…IgY is resistant against specific pathogens based on the antigen the hens are immunized against. It has been shown to be effective against a variety of intestinal pathogens particularly diarrhoea pathogens such as bovine and human rotaviruses, bovine coronavirus, enterotoxigenic Escherichia coli (ETEC) and Salmonella (Diraviyam et al, 2014;Muller et al, 2015;Sui et al, 2011;Thu et al, 2017;Xu et al, 2011). IgY has attracted considerable interest as an alternative to antibiotics for the control of infectious diseases in the alimentary tract (Li, Wang, Zhen, Li, & Xu, 2015).…”
Section: Introductionmentioning
confidence: 99%