Average Evoked Responses in Normal and Minimally Brain Dysfunctioned Children Treated With Amphetamine

Buchsbaum, Monte S.

doi:10.1001/archpsyc.1973.04200060050007

Cited by 115 publications

(34 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Children with ADHD showed greater amplitude variability than healthy controls during WM task, both in an easy WM task (BM1) over central and posterior regions and in a difficult WM task (BM2) over frontal, temporal, central and posterior regions. An increased ERP amplitude variability is reported by a number of other studies [16,40,41], and this is not always co-existent with increased response variability [20].…”

Section: Discussionmentioning

confidence: 76%

See 1 more Smart Citation

Within-subject variability during spatial working memory in children with ADHD: an event-related potentials study

Myatchin

Lemiere

Danckaerts

et al. 2012

Eur Child Adolesc Psychiatry

View full text Add to dashboard Cite

Working memory (WM) dysfunction and increased within-subject variability are known issues in attention deficit/hyperactivity disorder (ADHD) patients. Little is known about the electrophysiological characteristics of this variability. We evaluated behavioral and electrophysiological within-subject variability taking developmental aspects into account in a group of ADHD patients. Multichannel (n = 31) event-related potentials (ERP) were measured during a visuo-spatial backmatching task; 44 children (8-16 years old) were tested: 22 children with ADHD, combined (n = 17) and inattentive (n = 5) type, and 22 age- and intelligence-matched control children. One-backmatching (BM1) and two-backmatching (BM2) tasks were performed. Classical behavioral parameters and target and nontarget ERP were compared between groups. In addition, motor response variability and ERP amplitude variability were studied. Age-related changes in both motor response and ERP amplitude variability were analyzed in each group. Attention deficit/hyperactivity disorder children made more commission errors, which was more pronounced in the difficult (BM2) task. No difference between groups was found in ERP amplitude and in motor response variability. However, ADHD patients had higher ERP amplitude variability, which was again more pronounced in the difficult WM task. A delayed maturation of amplitude variability was seen in ADHD patients with a slower than in controls decrease in variability with age. This amplitude variability was correlated with the number of commissions, but in an opposite way for ADHD and control children. Our findings indicate an impaired visuo-spatial WM processing in ADHD children with greater ERP amplitude variability compared to controls. Our results also support the view of a delayed cortical development of visuo-spatial WM circuits in this disorder.

show abstract

Section: Discussionmentioning

confidence: 76%

“…In the BM1 task there was no global difference in SD of RT between ADHD and control groups (F (1,40) = 0.06, p = 0.8, g 2 = 0.002). With respect to maturation, in both ADHD and control groups younger participants had the highest SD of RT, which lowered significantly as age increased.…”

Section: Response Variabilitymentioning

confidence: 86%

Within-subject variability during spatial working memory in children with ADHD: an event-related potentials study

Myatchin

Lemiere

Danckaerts

et al. 2012

Eur Child Adolesc Psychiatry

View full text Add to dashboard Cite

show abstract

“…In the study by Hall et al [12], in which 2 samples of hyperactive children were investigated, the earlier find ings of Buchsbaum and Wender [11] concerning the cor relation between amphetamine response and the slope of the ASF were not replicated. However, several predrug ERP variables were significantly related to the drug …”

Section: Psychos Ti M Ulantsmentioning

confidence: 91%

Event-Related Potentials and the Prediction of Differential Drug Response in Psychiatry

Hegerl¹,

Herrmann²

1990

Neuropsychobiology

View full text Add to dashboard Cite

Differences in physiological trait or state characteristics of the organism are ultimately responsible for the wide range of interindividual variability in the clinical response to psychoactive drugs. Event-related potentials (ERPs) appear especially valuable in assessing these physiological characteristics, and might therefore be useful as predictors of the individual drug response. Seven criteria for the selection of potential predictor variables are presented. A review of the literature reveals consistent, prospective and cross-validated results concerning the prediction of the clinical response to psychostimulants in hyperkinetic children. Consistent findings have also been reported concerning the relationship between ERPs and the antidepressive as well as prophylactic effects of lithium. Relating to other aspects of drug therapy in psychiatry, there have been isolated studies describing ERP differences between responders and nonresponders. It is concluded that the use of ERPs in the prediction of differential drug response is a promising research strategy, deserving more attention. Its relevance will be seen not only in its practical value for therapeutic decisions, but also in the clarification of therapeutic mechanisms.

show abstract

“…The present results could be compared with results obtained with N1P2 in those hyperkinetic children im proved by stimulant drugs: an increase of amplitude with methylphenidate, both under passive conditions, show ing no intensity effect [Dykman et al, 1983], and under attentive task conditions [Halliday et al, 1976], and a decrease of variability with amphetamine [Buschbaum and Wender, 1973], In view of the small sample size and the great inter subject variability, our results about AEP augmentingreducing as predictor of drug effects need further confir mation. However, the tendency found (responders tend to be augmenters) is also in line with previous results showing that the ameliorative effects of methylphenidate were more evident in hyperactive children showing aug menting AEP patterns [Dykman et al, 1983].…”

Section: Discussionmentioning

confidence: 57%

Auditory Evoked Potential Modifications according to Clinical and Biochemical Responsiveness to Fenfluramine Treatment in Children with Autistic Behavior

Bruneau

Barthélémy²,

Roux³

et al. 1989

Neuropsychobiology

View full text Add to dashboard Cite

Evoked potentials to auditory stimulations varying in intensity were studied in 13 children with autistic behavior treated with fenfluramine. Modifications of both amplitude and single-trial potential variability were considered according to the clinical and biochemical responsiveness to this drug. Six children (responders) were clinically improved by the treatment. Electrophysiological data were affected according to the clinical and biochemical responsiveness to fenfluramine: the auditory evoked potential amplitude increased, and the single-trial potential variability decreased at each intensity level only in responders whose dopaminergic metabolism was significantly modified by fenfluramine treatment. No modification was found in nonresponders. Both biochemical and electrophysiological results argued for an amphetamine-like action of fenfluramine in those autistic children whose attention deficits are associated with motor disturbances including hyperactivity.

show abstract

Average Evoked Responses in Normal and Minimally Brain Dysfunctioned Children Treated With Amphetamine

Cited by 115 publications

References 17 publications

Within-subject variability during spatial working memory in children with ADHD: an event-related potentials study

Within-subject variability during spatial working memory in children with ADHD: an event-related potentials study

Event-Related Potentials and the Prediction of Differential Drug Response in Psychiatry

Auditory Evoked Potential Modifications according to Clinical and Biochemical Responsiveness to Fenfluramine Treatment in Children with Autistic Behavior

Contact Info

Product

Resources

About