Event-Related Potentials and the Prediction of Differential Drug Response in Psychiatry

Hegerl, Ulrich; Herrmann, W. M.

doi:10.1159/000119434

Cited by 21 publications

(7 citation statements)

References 22 publications

(23 reference statements)

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“…Consistent with these findings, augmenters of the ERPs tend to be high sensation seekers, and reducers tend to be sensation avoiders 13 16 17 24 25 26 27 . Augmenting of the auditory N1/P2 amplitude has been suggested to reflect low central serotonergic neurotransmission, and vice versa 15 , a finding which appears in line with observations that responders to antidepressant or prophylactic medication are augmenters, whereas non-responders tend to be reducers 14 15 28 29 .…”

supporting

confidence: 71%

Personality and Augmenting/Reducing (A/R) in auditory event-related potentials (ERPs) during emotional visual stimulation

Pascalis

Fracasso

Corr

2017

Sci Rep

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An auditory augmenting/reducing ERP paradigm recorded for 5 intensity tones with emotional visual stimulation was used, for the first time, to test predictions derived from the revised Reinforcement Sensitivity Theory (rRST) of personality with respect to two major factors: behavioral inhibition system (BIS), fight/flight/freeze system (FFFS). Higher BIS and FFFS scores were negatively correlated with N1/P2 slopes at central sites (C3, Cz, C4). Conditional process analysis revealed that the BIS was a mediator of the association between the N1/P2 slope and the FFFS scores. An analysis of covariance showed that lower BIS scorers exhibited larger N1/P2 amplitudes across all tone intensities while watching negative, positive and neutral pictures. Additionally, lower FFFS scorers compared to higher FFFS scorers disclosed larger N1/P2 amplitudes to the highest tone intensities and these differences were even more pronounced while watching positive emotional pictures. Findings were explained assuming the operation of two different, but related processes: transmarginal inhibition for the BIS; the attention/emotional gating mechanism regulating cortical sensory input for the FFFS trait. These findings appear consistent with predictions derived from the rRST, which traced fear and anxiety to separate but interacting neurobehavioural systems.

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supporting

confidence: 71%

Personality and Augmenting/Reducing (A/R) in auditory event-related potentials (ERPs) during emotional visual stimulation

Pascalis

Fracasso

Corr

2017

Sci Rep

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“…Following the basic work by Buchsbaum et al [6], several studies found that patients with bipolar affective dis-orders (BAD) show a pronounced augmenting disposition in comparison to healthy controls. Another finding is that responders to antidepressant or prophylactic medication are augmenters, whereas nonresponders tend to be reducers [7,8]. With regard to unipolar depression (UPD), Buchsbaum's findings suggest that these patients exhibit a significantly lower intensity dependence than did BAD patients and healthy controls, thereby showing themselves to be reducers [9].…”

Section: Introductionmentioning

confidence: 99%

“…So far, studies on the effect of antidepressant medication with UPD patients have been mainly restricted to clinical responsiveness studies [8,16].…”

Section: Introductionmentioning

confidence: 99%

Sensation Seeking and Affective Disorders: Characteristics in the Intensity Dependence of Acoustic Evoked Potentials

et al. 2000

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Augmenting/reducing of the evoked potential has been shown to be related to sensation seeking (SS) and specific clinical disorders. Buchsbaum demonstrated that patients with bipolar affective disorders (BAD) tend to be augmenters, as is the case with sensation seekers, and patients with unipolar affective disorders (UPD) tend to be reducers. In addition, he reported that prophylactic medication reduced the tendency to augment in bipolar patients. However, evidence for these relations is restricted to a few studies. This study explores whether Buchsbaum’s initial findings can be found in a naturalistic clinical setting. Acoustic evoked potentials were recorded for six levels of intensity (59, 71, 79, 88, 92, 96 dB SPL) from 24 healthy adults, 21 unipolar depressed patients, and 21 patients with BAD. Participants also completed personality questionnaires, especially the Sensation Seeking Scales Form V. Results revealed a positive correlation between SS and augmenting/reducing in healthy controls, thereby replicating earlier findings. Bipolar depressed patients showed larger P1/N1 slopes than healthy controls, when medication was statistically controlled. Unipolar depressed patients showed smaller P2 slopes, but only when medication was not controlled. Implications of these results for further research on augmenting/reducing and affective disorders and their relationship to SS are discussed.

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“…V O l 3 . 1996 reported that patients with a strong intensity dependence of sensory evoked potentials are responders to acute antidepressive or antimanic lithium therapy (for review see Hegerl and Herrmann, 1990). We found that patients with affective psychoses responding to preventive lithium medication were also characterized by a strong intensity dependence of AEP (Hegerl et al, 1987).…”

Section: Arguments For a Relationship Between Serotonergic Function Amentioning

confidence: 58%

ERP and neurotransmitters

Hegerl

Juckel

Möller

1996

Euro J of Neurology

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The increasing knowledge concerning anatomical structures and cellular processes underlying event‐related potentials (ERP) and methodological advances in ERP data analysis (e.g. dipole source analysis) begins to bridge the gap between ERP and neurochemical aspects. Several recent reports are summarized suggesting that quite specific relationships may exist between certain ERP‐parameters and central cholinergic, noradrenergic and especially serotonergic function. Reliable indicators of the serotonin system are urgently needed because of its role in pathogenetic concepts and as target of pharmacotherapeutic interventions in psychiatric and neurologic disorders. Converging arguments from preclinical and clinical studies are presented supporting the hypothesis that the dependence of the auditory evoked N1/P2‐response on stimulus intensity (loudness) is regulated by the level of central serotonergic neurotransmission. Dipole source analysis represents an important methodological advance in this context, because N1/P2‐subcomponents, generated by different cortical structures with different serotonergic innervations, can be separated. A pronounced intensity dependence of the evoked activity of primary auditory cortices is supposed to indicate a low central serotonergic neurotransmission and vice versa. This intensity dependence is shown to be a parameter with clinical value because subgroups of patients with a serotonergic dysfunction can be identified and can be treated more specifically.

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Event-Related Potentials and the Prediction of Differential Drug Response in Psychiatry

Cited by 21 publications

References 22 publications

Personality and Augmenting/Reducing (A/R) in auditory event-related potentials (ERPs) during emotional visual stimulation

Personality and Augmenting/Reducing (A/R) in auditory event-related potentials (ERPs) during emotional visual stimulation

Sensation Seeking and Affective Disorders: Characteristics in the Intensity Dependence of Acoustic Evoked Potentials

ERP and neurotransmitters

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