Avaliação prospectiva do perfil lipídico na artrite reumatóide

Abstract

Objective: To evaluate the lipid profile in rheumatoid arthritis and its association with the disease activity. Methods: This was a prospective study with 21 female patients who had rheumatoid arthritis and whose progress was accompanied for 1 year. Total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, apolipoproteins A and B, lipoprotein (a), ESR, as well as HAQ and disease activity through DAS28, were evaluated. Results: After 1 year, the total cholesterol level was increased in 66.6% of the patients (p=0.019) and the LDL-cholesterol level was also elevated in 80.9% of the patients (p=0.008). In contrast, the lipoprotein (a) level was reduced in 33.33% of the cases (p=0.003). A significant decrease also occurred in ESR, HAQ and DAS28. However, there was no association between the alteration of the lipid profile and the disease activity. Conclusion: Although the reduction in the disease activity (DAS28) was significant, the lipid profile worsened.

Laryngeal involvement in rheumatoid arthritis

“…The RA patients in this study had moderate disease activity 19 , 20 , with a DAS-28 score lower than what has been found in other populations. Corbacho et al 21 , Avelar et al 22 and Ranzolin et al 23 found DAS-28 scores equal to 4.68 ± 1.79; 6.33 ± 0.92 and 4.23 ± 1.2 points. There are no studies assessing the DAS-28 relationship with the laryngeal changes.…”

Perfil lipídico em pacientes adultos com artrite idiopática juvenil

“…2,3 Muitos estudos foram feitos na artrite reumatoide (AR) do adulto e mostraram claramente essa repercussão, que gera aumento de risco de morte pelas complicações cardiovasculares. 7 O uso crônico de glicocorticoides para tratamento dessa entidade tem sido ligado à ocorrência de hipercolesterolemia. 7 O uso crônico de glicocorticoides para tratamento dessa entidade tem sido ligado à ocorrência de hipercolesterolemia.…”