Avaliação in vivo do efeito hipocolesterolêmico e toxicológico preliminar do extrato bruto hidroalcoólico e decocção da Vitex megapotamica (Spreng) Moldenke (V. montevidensis Cham.)

Abstract

Unitermos: Vitex megapotamica, Lamiaceae, hipocolesterolemia, hipotrigliceridemia.ABSTRACT: "Evaluation of prospective hypocholesterolemic effect and preliminary toxicology of crude extract and decoction from Vitex megapotamica (Spreng) Moldenke (V. montevidensis Cham.) in vivo". The cardiovascular diseases are, in general, associated with high levels of serum lipids which have high incidence in middle-age men and women. Among other properties characterized by popular medicine, the Vitex megapotamica (Spreng) Moldenke (V. montevidensis Cham) -Tarumã, decreases the serum cholesterol and triacylglycerol levels. The main proposition of the present study was to evaluate the hypocholesterolemic and hipolipidaemic potential of V. megapotamica and to analyze the preliminary toxicity. It was an induction hyperlipidaemic model using propiltiuracil 1.25 mg/kg weight and cholesterol 200 mg/ kg weight per oros in male rats, weigthing 300 ± 10 g. It was administred to the animals 300 mg/ kg of hydroalcoholic leaves extract of V. megapotamica or 300 mL of hull decoction per oros. After the end of each treatment, the lipid profile was essayed as well as glucose, when relevant. Our results confirmed the V. megapotamica extract and decoction hypolipidaemic effect by the decrease of cholesterol and triacylglycerides serum levels in concentration, via and preparation performed. Furthermore, the toxicological preliminary assays showed there was not extract and decoction damage induction in cardiac and hepatic tissues, as well as in kidney physiology by assays performed.

Renoprotective Effects ofVitex megapotamica(Spreng.) Moldenke in C57BL/6 LDLr-Null Mice Undergoing High Fat Diet

“…In addition to activities directly renoprotective, MEVM treatment was able to reduce the TC levels in LDLr-null mice without affecting the elevation of HDL levels. Furthermore, a significant reduction in serum triglyceride was also observed, as previously reported [ 7 ]. Treatment with the highest dose of MECS showed significant reduction in the atherosclerotic index serum (AIS), with potential cardiovascular and renoprotective effect of this species.…”

“…In folk medicine, the infusion of the leaves of this plant is used in the treatment of hemorrhoids, hypertension, and as diuretic, hypocholesterolemic, anti-inflammatory, among other therapeutic properties [ 5 , 6 ]. This species has been characterized due to the presence of various substances of pharmacological interest, such as tannins, flavonoid glycosides, polyphenols, alkaloids, saponins, and essential oils [ 7 , 8 ].…”

“…Few pharmacological and toxicological studies have been carried out with this species. Brandt et al [ 7 ] have shown hypolipidemic effect by the decrease of serum cholesterol and triacylglycerides levels in mice after administration of the ethanolic extract and decoction obtained from Vitex megapotamica . Furthermore, two toxicological preliminary assays have shown no mutagenic activity or damage in cardiac and hepatic tissues, as well as in kidney physiology [ 7 , 8 ].…”

Total Phenolic and Flavonoid Content and Antioxidant Activity of Vitex Montevidensis (Spreng) Moldenke - Verbenaceae

“…The isolation of steroids and iridoids (Rimpler, 1969;Rimpler, 1972), a hypoglycemic activity of the leaves of V. megapotamica (Zanatta et al, 2007), the hypolipidemic effect of the crude hydroalcoholic extract and the decoction of the bark, including their contribution in reducing serum levels of cholesterol and triglyceride (Brandt et al, 2009), have been reported for the species under study.…”

<b> ANÁLISE FITOQUÍMICA DAS FOLHAS DE VITEX MEGAPOTAMICA (SPRENGEL) MOLDENKE </b>

“…10 e em 2009, foi demonstrado a ação do extrato bruto hidroalcóolico e decocção das cascas sobre efeito hipolipidêmico e redução dos níveis séricos de colesterol e triacilglicerol. 11 Estes mesmos autores realizaram um estudo fitoquímico preliminar do extrato bruto das folhas de V. megapotamica que revela a presença de taninos, glicosídeos flavonônicos, polifenóis, alcalóides, óleos essências e saponinas. Sendo assim, devido à escassez de estudos que comprovem tais efeitos, este estudo teve como objetivo realizar uma análise farmacognóstica dos extratos de V. megapotamica em diferentes solventes.…”