Avaliação ecocardiográfica evolutiva do infarto do miocárdio em ratos jovens e adultos

Pabis, Francisco Cesar; Miyague, Nelson Itiro; Francisco, Júlio César; Woitowicz, Vinícius; Carvalho, Katherine Athayde Teixeira de; Faria-Neto, José Rocha; Moisés, Valdir Ambrósio; Guarita-Souza, Luiz César

doi:10.1590/s0066-782x2008001700007

Cited by 5 publications

(4 citation statements)

References 28 publications

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“…ECHO was performed in anesthetized animals (50 mg/kg of ketamine - Fort Dodge; Iowa, USA and 10 mg/kg of xylazine - Bayer; Germany, intramuscularly 11 . The functional analysis was carried out by a two-dimensional device for transthoracic echocardiography (5500 Sonos, Hewlet Packard) with S12 (5 - 12 MHz) sectors conductor and 15L6 (7-15 MHz), which allowed the analysis of up to 160 MHz.…”

Section: Methodsmentioning

confidence: 99%

Short-Term Thyroid Hormone Excess Affects the Heart but Does not Affect Adrenal Activity in Rats

Szkudlarek¹,

Aldenucci²,

Miyagui³

et al. 2014

Arquivos Brasileiros De Cardiologia

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BackgroundHyperthyroidism (Hy) exerts a broad range of influences on a variety of physiological parameters. Its disruptive effect on cardiovascular system is one of its most remarkable impacts. Moreover, Hy has been clinically associated with stress - induced hyperactivation of the hypothalamic-pituitary-adrenal axis.ObjectiveEvaluate the impact of short-term Hy on cardiac performance and adrenal activity of rats.MethodsInduction of Hy in Wistar rats through injections of T3 (150 µg/kg) for 10 days (hyperthyroid group - HG) or vehicle (control group). The cardiovascular performance was evaluated by: echocardiography (ECHO); heart weight/body weight (mg/gr) ratio; contractility of isolated papillary muscles (IPM) and direct measurement of blood pressures. Adrenal activity was evaluated by adrenal weight/body weight (mg/gr) ratio and 24-hour fecal corticosterone (FC) levels on the, 5th and 10th days of T3 treatment.ResultsIn HG, the ECHO showed reduction of the End Systolic and End Diastolic Volumes, Ejection, Total Diastolic and Isovolumic Relaxation Times, Diastolic and Systolic Areas and E/A ratio. Heart Rate, Ejection Fraction and Cardiac Output increased. The heart weight/body weight ratio was higher. Similarly, in IPM, the maximum rate of force decay during relaxation was higher in all extracellular calcium concentrations. Systolic blood pressure (SBP) levels were higher. (p ≤ 0.05). On the other hand, there was no difference in the adrenal weight/body weight ratio or in the 24-hour FC levels.ConclusionsHy induces positive inotropic, chronotropic and lusitropic effects on the heart by direct effects of T3 and increases SBP. Those alterations are not correlated with changes in the adrenal activity.

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Section: Methodsmentioning

confidence: 99%

Short-Term Thyroid Hormone Excess Affects the Heart but Does not Affect Adrenal Activity in Rats

Szkudlarek¹,

Aldenucci²,

Miyagui³

et al. 2014

Arquivos Brasileiros De Cardiologia

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“…The intrinsic determinants include the rat's age and lineage, individual variations in the anatomy of the coronary artery, and individual physiological factors. On the age of the rat, spontaneous improvement in systolic function and ventricular volume can occur within 30 days after creation of an AMI in young rats [ 12 ] . Hence, adult rats whose ages of the approximately 150 days and have a body weight of approximately 350 grams are preferred for creating the experimental AMI [ 12 ] .…”

Section: Discussionmentioning

confidence: 99%

“…On the age of the rat, spontaneous improvement in systolic function and ventricular volume can occur within 30 days after creation of an AMI in young rats [ 12 ] . Hence, adult rats whose ages of the approximately 150 days and have a body weight of approximately 350 grams are preferred for creating the experimental AMI [ 12 ] . The extrinsic determinants include the site of the occlusion, which is dependent of the surgeon's experience and skill in occluding the LADCA.…”

Section: Discussionmentioning

confidence: 99%

“…Consequently, cardiac muscle tissue loss results in a decrease in LVEF with an increase in end systolic and end diastolic volume of the left ventricle. This process results in ventricular dilatation and an increase in diastolic tension [ 10 , 12 ] . We found no significant differences in the echocardiographic measurements of the G1 and G2 rats whose LVEF were less than 40%.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of Two Surgical Techniques for Creating an Acute Myocardial Infarct in Rats

Capriglione¹,

Barchiki²,

Ottoboni³

et al. 2014

Revista Brasileira De Cirurgia Cardiovascular

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ObjectiveTo perform a comparative assessment of two surgical techniques that are used creating an acute myocardial infarc by occluding the left anterior descending coronary artery in order to generate rats with a left ventricular ejection fraction of less than 40%.MethodsThe study was completely randomized and comprised 89 halothane-anaesthetised rats, which were divided into three groups. The control group (SHAM) comprised fourteen rats, whose left anterior descending coronary artery was not occluded. Group 1 (G1): comprised by 35 endotracheally intubated and mechanically ventilated rats, whose left anterior descending coronary artery was occluded. Group 2 (G2): comprised 40 rats being manually ventilated using a nasal respirator whose left anterior descending coronary artery was occluded. Other differences between the two techniques include the method of performing the thoracotomy and removing the pericardium in order to expose the heart, and the use of different methods and suture types for closing the thorax. Seven days after surgery, the cardiac function of all surviving rats was determined by echocardiography.ResultsNo rats SHAM group had progressed to death or had left ventricular ejection fraction less than 40%. Nine of the 16 surviving G1 rats (56.3%) and six of the 20 surviving G2 rats (30%) had a left ventricular ejection fraction of less than 40%.ConclusionThe results indicate a tendency of the technique used in G1 to be better than in G2. This improvement is probably due to the greater duration of the open thorax, which reduces the pressure over time from the surgeon, allowing occlusion of left anterior descending coronary artery with higher accuracy.

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Surgical and physiological challenges in the development of left and right heart failure in rat models

et al. 2019

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Avaliação ecocardiográfica evolutiva do infarto do miocárdio em ratos jovens e adultos

Abstract: SummaryBackground: The regeneration of cardiomyocytes after a myocardial infarction (MI) is more evident in young animals; however, it is not known whether it is associated with functional improvement.

Cited by 5 publications

References 28 publications

Short-Term Thyroid Hormone Excess Affects the Heart but Does not Affect Adrenal Activity in Rats

Short-Term Thyroid Hormone Excess Affects the Heart but Does not Affect Adrenal Activity in Rats

Comparison of Two Surgical Techniques for Creating an Acute Myocardial Infarct in Rats

Surgical and physiological challenges in the development of left and right heart failure in rat models

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