Avaliação do ritmo de filtração glomerular

Kirsztajn, Gianna Mastroianni

doi:10.1590/s1676-24442007000400007

Cited by 15 publications

(15 citation statements)

References 22 publications

(30 reference statements)

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“…28 But we cannot forget that, in elderly patients, glomerular filtration may decrease as part of the body's aging process, and it can be difficult to differentiate the age-related decrease in glomerular filtration from that seen in renal dysfunction in the elderly. Therefore, for purposes of stratification and intervention, the diagnosis of renal dysfunction should not be solely based on the estimate of GFR, but also the presence of other markers of kidney disease.…”

Section: Discussionmentioning

confidence: 99%

Estimated glomerular filtration rate in patients with type 2 diabetes mellitus

Fontela¹,

Winkelmann²,

Ott

et al. 2014

Rev. Assoc. Med. Bras.

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Objective: to estimate the glomerular filtration using the Cockcroft-Gault (CG), Modification of Diet in Renal Disease (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations, and serum creatinine in the screening of reduced renal function in patients with type two diabetes (T2DM) enrolled in the Family Health Strategy (ESF, Brazilian federal healthcare program). Methods: a cross-sectional descriptive and analytical study was conducted. The protocol consisted of sociodemographics, physical examination and biochemical tests. Renal function was analyzed through serum creatinine and glomerular filtration rate (GFR) estimated according to the CG, MDRD and CKD-EPI equations, available on the websites of the Brazilian Nephrology Society (SBN) and the (NKF). Results: 146 patients aged 60.9±8.9 years were evaluated; 64.4% were women. The prevalence of serum creatinine >1.2 mg/dL was 18.5% and GFR <60 mL/min/1.73m² totaled 25.3, 36.3 and 34.2% when evaluated by the equations CG, MDRD and CKD-EPI, respectively. Diabetic patients with reduced renal function were older, had long-term T2DM diagnosis, higher systolic blood pressure and higher levels of fasting glucose, compared to diabetics with normal renal function. Creatinine showed strong negative correlation with the glomerular filtration rate estimated using CG, MDRD and CKD-EPI (-0.64, -0.87, -0.89) equations, respectively. Conclusion: the prevalence of individuals with reduced renal function based on serum creatinine was lower, reinforcing the need to follow the recommendations of the SBN and the National Kidney Disease Education Program (NKDEP) in estimating the value of the glomerular filtration rate as a complement to the results of serum creatinine to better assess the renal function of patients.

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Section: Discussionmentioning

confidence: 99%

Estimated glomerular filtration rate in patients with type 2 diabetes mellitus

Fontela¹,

Winkelmann²,

Ott

et al. 2014

Rev. Assoc. Med. Bras.

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“…The Jaffé method was used to measure serum creatinine, and loss of renal function was defined as creatinine > 1.4mg/dL 29 .…”

Section: Methodsmentioning

confidence: 99%

Hyperuricemia and associated factors: a cross-sectional study of Japanese-Brazilians

et al. 2011

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IntroductionThe scientific literature makes widespread reference to the association between chronic noncommunicable diseases, especially rheumatic and cardiovascular diseases, and hyperuricemia 1,2,3 . The relationship between excess plasma uric acid and gout is described in the literature, but despite all the studies and technological advances, there is still limited evidence to show a direct relationship between hyperuricemia and cardiovascular diseases 3,4,5 .According to previous studies, some foods can help increase or decrease the serum uric acid levels 6,7,8 , depending on their purine content. There is still little information on the exact amount of purines contained in foods, since their content and availability depend on the food processing procedures, among other factors 4,9,10 .Various studies 3,8,11,12,13 have pointed to excessive intake of fat, alcohol, and fructose, as well as changes in body weight (both excess weight and sudden weight loss) as risk factors for hyperuricemia. In addition, a reduction in the consumption of protein-rich foods (especially animal protein) can help decrease the blood uric acid levels 11,13 . The literature includes reports that excess body fat may be the most important nutritional factor for hyperuricemia 2,4,14 .According to previous publications, hyperuricemia is associated with various chronic diseases such as arterial hypertension, cardio-ARTIGO ARTICLE Poletto J et al. 370 Cad. Saúde Pública, Rio de Janeiro, 27(2):369-378, fev, 2011

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“…A creatinina é um marcador de lesão renal mais eficaz que a ureia, pois em animais sadios ela não é reabsorvida pela parede das células dos túbulos renais, além de não ser influenciada pela dieta (Kirsztajn et al 2007, Braun et al 2010. Embora a creatinina se mostre elevada apenas quando há comprometimento de mais de 70% dos né-frons (Kozloski et al 2005), a análise conjunta da ureia e ausência do quadro clínico compatível com nefropatia dos animais permitiu excluir disfunções renais durante o experimento.…”

Section: Ureia E Creatinina Séricasunclassified

Avaliação clínica, laboratorial e anatomopatológica do sistema urinário de ovinos confinados com ou sem suplementação de cloreto de amônio

et al. 2016

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Resumo: A acidificação urinária com cloreto de amônio (CA) é um método preventivo eficiente em urolitíase obstrutiva em ovinos. Os objetivos deste estudo com ovinos confinados, que receberam dieta concentrada com elevado teor proteico, foram: verificar o efeito da dieta sobre a formação de urólitos e o desenvolvimento da doença; analisar as características macroscópicas e histopatológicas do sistema urinário; relacionar os achados clínicos, laboratoriais e necroscópicos com a presença de urólitos. Utilizaram-se 60 ovinos machos: grupo CA (n=40), 400 mg/kg CA/dia, tratados via oral, por 42 dias consecutivos; grupo-controle (n=20), não tratado. Determinaram-se sete momentos de colheita de amostras com intervalos de sete dias, no total de 56 dias de confinamento. Encontraram-se microcálculos na pelve renal em cinco animais de ambos os grupos. As lesões renais microscópicas mais relevantes foram congestão vascular e necrose tubular. Concluiu-se que a dieta rica em concentrado provocou lesão renal em ambos os grupos, embora sem alterar a função renal, o que foi comprovado em testes pela ureia e creatinina séricas. O cloreto de amônio fornecido ao grupo CA não impediu a calculogênese, mas reduziu sua prevalência em relação ao grupo-controle. Os ovinos do grupo-controle tiveram maior comprometimento renal, pela alta incidência de cristalúria e pela necrose tubular, induzidas pelo consumo da dieta rica em grãos.

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Avaliação do ritmo de filtração glomerular

Cited by 15 publications

References 22 publications

Estimated glomerular filtration rate in patients with type 2 diabetes mellitus

Estimated glomerular filtration rate in patients with type 2 diabetes mellitus

Hyperuricemia and associated factors: a cross-sectional study of Japanese-Brazilians

Avaliação clínica, laboratorial e anatomopatológica do sistema urinário de ovinos confinados com ou sem suplementação de cloreto de amônio

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