2018
DOI: 10.1590/1678-4162-9462
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Abstract: RESUMO Foram avaliados os efeitos tóxicos do hormônio 17β-estradiol (E2) livre e complexado à β-ciclodextrina (CD) sobre o comportamento e a fisiologia de tilápia (Oreochromis niloticus). Os peixes foram observados por 30 dias, em dois estágios do desenvolvimento (alevino e juvenil), pelo método ad libitum, para a confecção de um etograma. Posteriormente, juvenis foram divididos em três grupos: controle e expostos ao E2 (10ng/L) livre e complexado à β-ciclodextrina (β-CD:E2) por 90 dias. Foram avaliados o comp… Show more

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Cited by 2 publications
(2 citation statements)
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“…Complexation with cyclodextrins is one of the most commonly used strategy to increase the solubility, stability and safety of poorly soluble molecules [11]. Thus, the physicochemical characterization of such complexes is of utmost importance in order to prove that complexation has taken place.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Complexation with cyclodextrins is one of the most commonly used strategy to increase the solubility, stability and safety of poorly soluble molecules [11]. Thus, the physicochemical characterization of such complexes is of utmost importance in order to prove that complexation has taken place.…”
Section: Discussionmentioning
confidence: 99%
“…Cyclodextrins (CDs) are cyclic oligosaccharides of a variable number of glucose units, linked by α-(1,4) glycosidic bonds. They are characterized by a hydrophobic cavity and a hydrophilic exterior, and for this reason, CDs are able to host hydrophobic molecules in their interior, therefore, forming the so-called inclusion complexes (ICs) [11]. Some drugs are already marketed in Europe, Japan, United States and Brazil as complexes with cyclodextrins, which includes dexamethasone, nimesulide, omeprazole, piroxicam, indomethacin and itraconazole [12,13].…”
Section: Introductionmentioning
confidence: 99%