Avaliação do efeito da clorpromazina sobre a função renal de cães submetidos à isquemia e reperfusão

Abstract

ABSTRACT.-Menezes L.B., Fioravanti M.C.S., Silva M.S.B., Franco L.G., Sales T.P., Andrascko M.M., Veado J.C. Renal ischemia may occur in different situations such as vascular or renal surgery and also in renal transplantation. This study evaluates renal function in dogs submitted to ischemia and reperfusion after chlorpromazine application. Twelve adult mongrel dogs were distributed into two groups with six animals each. Group A was composed of dogs submitted to renal ischemia and reperfusion without previous administration of chlorpromazine. Group B was composed of dogs with renal ischemia and reperfusion previously treated with chlorpromazine. In order to evaluate the possible ischemia/ reperfusion late effects, blood and urine samples were sampled in four different times: Before ischemia, early stages of reperfusion, 120 minutes after reperfusion, and every week until 28th day postsurgery. Renal function was evaluated by clinical examination, serum urea and creatinine levels and urinary GGT activity. PU/CU and GGT urinary activity were more sensitive in detecting acute tubular injury than routine urine examination because these variables showed earlier changes. Based on urinalysis, urea and creatinine serum levels plus urinary excretion of GGT and PU/CU, no evidences of protective action of chlorpromazine were observed.INDEX TERMS: Fenotiazinic, gamma-glutamiltransferase, acute renal failure.

Biochemical parameters of the giant anteater (Myrmecophaga tridactyla Linnaeus, 1758) of the Brazilian Cerrado

“…Because they are eliminated exclusively by the kidneys, the increase in these metabolites suggests a failure in renal function (Menezes et al 2010). The mean creatinine levels were very similar to those proposed previously, indicating that several extrinsic factors such as location, time of year and nutritional status of these animals did not interfere in the serum levels of this analyte.…”

Renal biomarkers of male and female Wistar rats (Rattus norvegicus) undergoing renal ischemia and reperfusion

“…Menezes et al 23 note that assessment of the UP/UCr ratio and GGT urine activity are more sensitive exams than the routine urine exam in detecting acute tubular injury (ATI), since these variables present changes before serum urea and creatinine. In this study, the UP/UCr ratios observed in the I/R animals were higher than in the control group at 24 hours, and at five and seven days, with a tendency to return to normal levels on the 14 th and 21 st days, possibly indicating the increased excretion of protein in urine and a potential risk of (ATI) in the first days, with subsequent regeneration.…”

Functional and Morphostructural Evaluation of the Kidneys of Wistar Rats after the Use of a Protein-Based Food Supplement

“…The results of this study corroborate the study of Martin et al who reported that the renal impact due to a highprotein diet for a short period of time is different from the impact caused by a chronic consumption of this type of diet; therefore, the supplementation period of 14 days was insufficient to cause a significant change in the protein metabolism and increased level of this metabolite [6]. The serum urea generally does not increase until more than 60% of nephrons do not function; therefore, this is a high specificity but low sensitivity marker [7].…”