Avaliação do desempenho de um teste rápido imunocromatográfico no diagnóstico de hanseníase em uma região endêmica no norte do Brasil

Gois, Rosineide Vieira; Travaim, Sâmela Fideles; Prata, Gabrielle Melo Calegari; Degen, Andressa Nayara; Pereira, Giselle Cristina Andrade; Wolf, Jonas Michel; Silva, Márcia Susana Nunes

doi:10.4322/2357-9730.84986

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…The negative results had a 100% agreement for both tests. These findings are in disagreement with those found in the literature, where the ML Flow test is reported to have a greater sensitivity than bacilloscopy, 17 , 30 but can be justified due to the constant collection training for bacilloscopy carried out in the studied region.…”

Section: Discussioncontrasting

confidence: 99%

ML Flow serological test: complementary tool in leprosy

Montanha¹,

Nardi²,

Tolentino³

et al. 2023

Anais Brasileiros de Dermatologia

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Section: Discussioncontrasting

confidence: 99%

ML Flow serological test: complementary tool in leprosy

Montanha¹,

Nardi²,

Tolentino³

et al. 2023

Anais Brasileiros de Dermatologia

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Accuracy of rapid point-of-care serological tests for leprosy diagnosis: a systematic review and meta-analysis

Romero

Castro

Brasil

et al. 2022

Mem. Inst. Oswaldo Cruz

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BACKGROUND Leprosy is a chronic infectious disease, still endemic in many countries that may lead to neurological, ophthalmic, and motor sequelae if not treated early. Access to timely diagnosis and multidrug therapy (MDT) remains a crucial element in the World Health Organization’s strategy to eliminate the disease as a public health problem. OBJECTIVES This systematic review aims to evaluate the accuracy of rapid point-of-care (POC) tests for diagnosis of leprosy. METHODS Searches were carried out in electronic databases (PubMed, EMBASE, CRD, Cochrane Library and LILACS) in April 2021 for patients with suspicion or confirmatory diagnostic of leprosy, classified in multibacillary (MB) or paucibacillary (PB) cases, performing rapid POC serological tests compared to clinical evaluation, smear microscopy and immunohistochemistry analysis. Methodological quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies tool (QUADAS-2). A meta-analysis was undertaken to generate pooled estimates of diagnostic parameters, presenting sensitivity, specificity and diagnostic odds ratio (DOR) values. The review protocol was registered at PROSPERO, CRD # 42014009658. FINDINGS From 893 potentially relevant references, 12 articles were included reporting 16 diagnostic tests accuracy studies with 5395 individuals enrolled. Meta-analysis of NDO-LID and PGL-I tests data in MB patients showed sensitivity and specificity [95% confidence interval (CI)] of 0.83 (0.71-0.91), 0.91 (0.72-0.97); and 0.92 (0.86-0.96), 0.93 (0.78-0.98); respectively, with high heterogeneity among the studies. MAIN CONCLUSIONS Our results can inform policymakers regarding the possibility of implementing accurate, rapid POC tests for leprosy in public health services, especially within primary health care.

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Avaliação do desempenho de um teste rápido imunocromatográfico no diagnóstico de hanseníase em uma região endêmica no norte do Brasil

Cited by 2 publications

References 13 publications

ML Flow serological test: complementary tool in leprosy

ML Flow serological test: complementary tool in leprosy

Accuracy of rapid point-of-care serological tests for leprosy diagnosis: a systematic review and meta-analysis

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