ML Flow serological test: complementary tool in leprosy

Montanha, Janaína Olher Martins; Nardi, Susilene Maria Tonelli; Tolentino, Fernanda Modesto; Pedro, Heloisa da Silveira Paro; Santi, Milena Polotto de; Paschoal, Vânia Del'Arco

doi:10.1016/j.abd.2022.05.005

Cited by 6 publications

(12 citation statements)

References 20 publications

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“…intradermal smear, providing less discomfort to the patient (Francisco et al, 2019). Furthermore, according to Montanha et al (2023), when comparing the results of sputum smear microscopy and the ML Flow test, there was an agreement of 75% between the positives and 100% between the negatives, with these results being considered satisfactory and promising for the rapid test.…”

Section: Resultsmentioning

confidence: 96%

“…Furthermore, the results indicate greater vulnerability in children aged between 8 and 14 years, associating it with precarious housing conditions, with the increase in cases in a younger age group suggesting a greater prevalence of M. Leprae, as it highlights the transmission of the disease in all age groups (Rodrigues et al, 2020;Araújo et al, 2020). According to Montanha et al (2023) and Rodrigues et al (2020), the occurrence of leprosy is closely related to unfavorable socioeconomic factors, precarious living conditions and waste disposal. This is due to the fact that people with limited resources often face challenges when seeking access to appropriate healthcare.…”

Section: Resultsmentioning

confidence: 99%

“…From this perspective, when analyzing the available technologies, it was possible to realize that the implementation of the rapid immunochromatographic test for the qualitative determination of IgM anti Mycobacterium leprae antibodies in the complementary diagnosis of Leprosy in the SUS (Unified Health System) helps to reduce the time between the appearance of symptoms and the beginning of treatment, in order to reduce the risk of permanent disabilities and the spread of the disease. Among the serological tests available, ML Flow is considered a quick, individual, easyto-perform test, with sensitivity and specificity similar to ELISA, in addition to providing a better cost-benefit ratio (Montanha et al, 2023).…”

Section: Resultsmentioning

confidence: 99%

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Evaluation of the Importance of Rapid Tests in the Early Diagnosis of Leprosy and Their Role in Promoting Public Health

Sousa,

Silva,

Cabral

et al. 2023

JHS

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INTRODUCTION: Leprosy still represents a serious public health problem in Brazil and the delay in detection can be attributed to the lack of diagnostic capacity and the absence of rapid tests. With this, Brazil became the first country to incorporate the rapid immunochromatographic test into the Unified Health System (SUS) for the early detection of leprosy -technology that plays a crucial role in promoting health, reducing the burden of the disease in the community, preventing disabilities and improving the quality of life of affected patients. This study aims to discuss the main scientific evidence about the importance of early detection of leprosy and the impact of rapid tests on the current epidemiological scenario of the disease. METHODS: This integrative review was based on 13 studies on the importance of rapid tests in the early diagnosis of Leprosy. The PICO strategy was used to construct the research question and articles were selected from databases such as MEDLINE/PubMed, SCIELO and LILACS. RESULTS: To advance the fight and achieve the global strategy towards zero leprosy, it is necessary to invest and advance in research and distribution of rapid tests, overcome infrastructural obstacles, in addition to improving the quality of clinical services for diagnosis and monitoring of leprosy complications. illness. Furthermore, psychological support for affected people and families is essential, ensuring their longitudinal approach. CONCLUSION: In short, this review highlights the persistence of leprosy in developing countries, identifying a succession of failures in the process of combating this disease. This way, the relevance of early diagnosis and the importance of implementing rapid testing in this investigation and reducing the burden of the disease in the community were highlighted.

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Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of the Importance of Rapid Tests in the Early Diagnosis of Leprosy and Their Role in Promoting Public Health

Sousa,

Silva,

Cabral

et al. 2023

JHS

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“…Additionally, the Fast ML Flow leprosy test yielded a positive result in this case. This is an IgM antibody detection test against the PGL-1 antigen (phenol glycolipid-1), which plays a pivotal role in facilitating early diagnosis, with a sensitivity of 90% and specificity of 98% 5 - 7 . It is a minimally invasive procedure that expedites initiation of treatment 3 .…”

Section: Discussionmentioning

confidence: 99%

“…Recently, the use of serological kits as diagnostic tools for neural leprosy has emerged as a promising approach. The anti-PGL1 IgM serology ELISA was a great advancement, being positive in 52% of multibacillary cases 4 , 5 . The use of the ML Flow test as a criterion for classification in one study increased to 11% of patients requiring treatment for multibacillary leprosy in Brazil 6 , 7 .…”

Section: Introductionmentioning

confidence: 99%

Neural leprosy investigation using electroneuromyography and the ML Flow rapid test: a case report

Oliveira Neto,

Dorilêo,

Mendonça

et al. 2024

Rev. Soc. Bras. Med. Trop.

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Neural leprosy, which is characterized by nerve involvement without visible skin lesions, presents a diagnostic challenge. This case report examined the significance of diverse diagnostic modalities in the identification of pure neural leprosy. A 28-year-old patient with symptoms of edema, pain, paresthesia, and diminished sensitivity in the lower limbs underwent various tests. A stilt skin smear yielded negative results on bacilloscopy, whereas a Fast ML Flow leprosy test and electroneuromyography supported the diagnosis. This discussion highlights the importance of accessible methods for early investigation. This study emphasizes the multidisciplinary approach and value of the Fast ML Flow leprosy test and electroneuromyography for diagnosing neural leprosy.

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