Avaliação da função e da lesão renal: um desafio laboratorial

Sodré, Fábio L.; Costa, Josete Conceição Barreto; Lima, José Carlos C.

doi:10.1590/s1676-24442007000500005

Cited by 60 publications

(63 citation statements)

References 38 publications

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“…21 However, studies indicate that the MDRD equation proves more effective in detecting changes in patients with early renal disease, 23 as seen in the present study, where the prevalence of decreased renal function was greater in diabetic patients assessed by MDRD.…”

Section: Discussionmentioning

confidence: 45%

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Estimated glomerular filtration rate in patients with type 2 diabetes mellitus

Fontela¹,

Winkelmann²,

Ott

et al. 2014

Rev. Assoc. Med. Bras.

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Objective: to estimate the glomerular filtration using the Cockcroft-Gault (CG), Modification of Diet in Renal Disease (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations, and serum creatinine in the screening of reduced renal function in patients with type two diabetes (T2DM) enrolled in the Family Health Strategy (ESF, Brazilian federal healthcare program). Methods: a cross-sectional descriptive and analytical study was conducted. The protocol consisted of sociodemographics, physical examination and biochemical tests. Renal function was analyzed through serum creatinine and glomerular filtration rate (GFR) estimated according to the CG, MDRD and CKD-EPI equations, available on the websites of the Brazilian Nephrology Society (SBN) and the (NKF). Results: 146 patients aged 60.9±8.9 years were evaluated; 64.4% were women. The prevalence of serum creatinine >1.2 mg/dL was 18.5% and GFR <60 mL/min/1.73m² totaled 25.3, 36.3 and 34.2% when evaluated by the equations CG, MDRD and CKD-EPI, respectively. Diabetic patients with reduced renal function were older, had long-term T2DM diagnosis, higher systolic blood pressure and higher levels of fasting glucose, compared to diabetics with normal renal function. Creatinine showed strong negative correlation with the glomerular filtration rate estimated using CG, MDRD and CKD-EPI (-0.64, -0.87, -0.89) equations, respectively. Conclusion: the prevalence of individuals with reduced renal function based on serum creatinine was lower, reinforcing the need to follow the recommendations of the SBN and the National Kidney Disease Education Program (NKDEP) in estimating the value of the glomerular filtration rate as a complement to the results of serum creatinine to better assess the renal function of patients.

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Section: Discussionmentioning

confidence: 45%

“…Using the results of this practical study to calculate GFR estimated by MDRD, which is considered more effective, 23 36.3% of the patients were found to present levels below 60 mL/min/1.73m 2 . This represents an approximate decrease of 50% in normal kidney function.…”

Section: Discussionmentioning

confidence: 99%

Estimated glomerular filtration rate in patients with type 2 diabetes mellitus

Fontela¹,

Winkelmann²,

Ott

et al. 2014

Rev. Assoc. Med. Bras.

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“…Enquanto a creatinina é um produto residual da creatina, sendo produzida de acordo com a massa muscular (7) .…”

Section: Discussionunclassified

“…A IRA está intimamente relacionada ao aumento da morbimortalidade de 10 a 15 vezes, o que acarreta aumento abusivo de recursos terapêuticos (4) . Existe um consenso que os exames laboratoriais de creatinina e ureia subsidiam o diagnóstico precoce e prevenção de complicações (7) . Por isso, neste estudo definiu-se como sendo IRA os pacientes que apresentaram alterações relativas no nível sérico da creatinina (SCr), sendo classificado como risco: um aumento da SCr entre 1,5 e 2 mg/dl; dano: quando os valores da creatinina sérica estiverem entre 2 e 3 mg/dl; falência: caso a SCr encontrar-se entre 3 e 4 mg/dl; e perda: se a creatinina sérica alcançar um valor superior a 4 mg/dl (4) .…”

Section: Introductionunclassified

Incidência E Fatores Predisponentes De Insuficiência Renal Aguda Em Unidade De Terapia Intensiva

et al. 2017

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INCIDENCE AND RISK FACTORS ASSOCIATED WITH ACUTE KIDNEY INJURY IN INTENSIVE CARE UNIT ABSTRACT:The study aims to identify the incidence, classification and risk factors for acute kidney injury in patients admitted to an intensive care unit. Descriptive documentary study with a quantitative approach, conducted from January to February 2016, based on the analysis of 114 medical records of hospitalized patients. The diagnosis was based on the criterion of the Acute Dialysis Quality Initiative. Incidence and the classification of acute kidney injury were assessed. Also, correlation was assessed using the Chi-square test (p<0.05) and Prevalence Ratio (p<0.05). The incidence rate of the disease is 44.7% (51 patients). Of these, most were at the risk class: 41% (20 patients).The development of disease is associated with changes in blood pressure levels, body fluid balance, inability of the kidneys to produce sufficient amounts of urine, and elevated blood urea and creatinine levels, and when complicated by the occurrence of acute respiratory diseases, mortality increases substantially. Strict monitoring of the identified factors is necessary, aiming at the early detection of acute kidney injury and decrease in mortality rates.

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“…In addition, it was found that the groups that consumed noni had lower serum creatinine levels and, in turn, a higher ratio of urea/creatinine, which may indicate the presence of processes leading to a decrease in renal blood flow, such as dehydration, congestive heart failure and prolonged febrile conditions (Sodré et al, 2007;Bastos, 2011).…”

Section: Discussionmentioning

confidence: 99%

Effects of Consumption of Noni (Morinda citrifolia) in Rats Fed a High-Fat Diet

Machado¹,

Sousa²,

Montenegro³

et al. 2016

IJMP

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Objective: To evaluate the effects of noni consumption on risk factors for cardiovascular disease, fasting glucose and hepatic and renal function in rats fed a high-fat diet. Methods: 18 Wistar rats were divided into three groups. Group control (C) was fed with high-fat diet and water. Group's noni juice (NJ) and noni infusion (NI) received the same diet and noni juice and infusion, respectively, for 4 weeks. After this time were assessed anthropometric measurements, adiposity, organ weights and biochemical measurements. Results: Groups NJ and NI had higher waist circumference compared to group C (C=11.0 cm, NJ=12.8 cm and NI=14.0 cm, p<0.05), lower serum creatinine (C=0.8 mg/dL, NJ=0.2 mg/dL and NI=0.3 mg/dL, p<0.05), and higher blood urea nitrogen/creatinine ratio (C=92.7, NJ=349.3 and NI=230.4, p<0.05). Noni infusion consumption promoted higher serum total cholesterol (C=59.7 mg/dL, NJ=60.1 mg/dL and NI=99.8 mg/dL, p<0.05) and LDL (C=48.5 mg/dL, NJ=42.0 mg/dL and NI=78.7 mg/dL, p<0.05). Conclusion: Consumption of noni, either as juice or as infusion, promoted higher waist circumference and blood urea nitrogen/creatinine ratio. Furthermore, noni infusion consumption promoted increased of serum total cholesterol and LDL

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Avaliação da função e da lesão renal: um desafio laboratorial

Cited by 60 publications

References 38 publications

Estimated glomerular filtration rate in patients with type 2 diabetes mellitus

Estimated glomerular filtration rate in patients with type 2 diabetes mellitus

Incidência E Fatores Predisponentes De Insuficiência Renal Aguda Em Unidade De Terapia Intensiva

Effects of Consumption of Noni (Morinda citrifolia) in Rats Fed a High-Fat Diet

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