Avaliação da atividade antibacteriana do óleo essencial de Rosmarinus officinalis L. e tintura de própolis frente à bactéria causadora da acne Propionibacterium acnes

Abstract

RESUMO:A acne é uma doença de pele extremamente comum. Sua patogênese é multifatorial, incluindo hiperqueratinização folicular, hiperplasia sebácea, hipercolonização bacteriana. A Propionibacterium acnes possui um papel relevante na resposta inflamatória da patogênese da acne. Os antibióticos representam uma das classes de medicamentos utilizadas no tratamento da acne. No entanto, as reações adversas causadas por esses fármacos tornam o tratamento desagradável, além de casos relatados de resistência bacteriana. Por esse motivo, o uso de produtos naturais tem sido destaque na área de dermatologia. O presente trabalho visou avaliar "in vitro" os possíveis efeitos antimicrobianos do óleo essencial de Rosmarinus officinalis e da tintura de própolis sobre cepa de Propionibacterium acnes (ATCC 1969). O óleo essencial foi extraído pela técnica de hidrodestilação e obteve-se a tintura de própolis por maceração. O ensaio antimicrobiano foi realizado pela técnica da diluição em tubos. O óleo foi testado em diferentes concentrações, variando de 16% a 0,0625% e a tintura de 10% a 0,072312%. Pode-se verificar que o óleo essencial de Rosmarinus officinalis L. não apresentou atividade antibacteriana contra a cepa de Propionibacterium acnes. A tintura de própolis teve ação em várias concentrações, sendo a concentração inibitória mínima de 0,625%. Palavras-chaves:Acne, Propionibacterium acnes, Rosmarinus officinalis, tintura de própolis.ABSTRACT: Evaluation of the antibacterial activity of the essential oil of Rosmarinus officinalis L. and propolis tincture against the bacterium that causes acne: Propionibacterium acnes. Acne is an extremely common skin disease. The pathogenesis of acne is multifactorial, including follicular hyperkeratinization, sebaceous hyperplasia and hypercolonization of bacteria. The Propionibacterium acnes has an important role in the inflammatory response of the pathogenesis of acne. Antibiotics are one of the drugs used in the treatment of acne. However, the adverse reactions caused by these drugs turn the treatment unpleasant, besides the existence of cases of bacterial resistance. For this reason, the use of natural products has been prominent in the dermatology area. This work intended to perform an in vitro evaluation of the possible antimicrobial effects of the essential oil of Rosmarinus officinalis and propolis tincture on the Propionibacterium acnes (ATCC 1969) strain. The essential oil was extracted by hydrodistillation, and the propolis tincture was obtained by maceration. The antimicrobial test was conducted by the tube dilution technique. The oil was tested in different concentrations varying between 16% and 0.0625%, and the tincture, between 10% and 0.072312%. We verified that the essential oil of Rosmarinus officinalis has no effects against the Propionibacterium acnes strain. The propolis tincture showed some action in several concentrations, being the minimal inhibitory concentration: 0.625%.

Avaliação Da Atividade Antibacteriana Do Pleurotus Ostreatus Isolados De Staphylococcus Aereus, Pseudomonas Aeruginosa E Escherichia Coli

“…Descriptores: Bioprospección; Hongo, Bacterias. 7,16 . Extrato Eluente C1 C2 C3 C1 C2 C3 C1 C2 C3 C1 C2 C3 E1 DMSO ------------E2 DMSO …”

Propolis and its Cosmetic Applications: A Technological Prospection

“…4 The chemical composition of propolis is subject to variations based on botanical biodiversity, seasonality and geographical location. 2,5 In general, it is composed of resin, wax, essential oils, pollen and other organic compounds, 2 among them flavonoids (flavones, flavonols and flavonones), terpenoids, aromatic acids, etc. 5 Therapeutic activities may occur through the synergism of these chemical compounds.…”

“…2,5 In general, it is composed of resin, wax, essential oils, pollen and other organic compounds, 2 among them flavonoids (flavones, flavonols and flavonones), terpenoids, aromatic acids, etc. 5 Therapeutic activities may occur through the synergism of these chemical compounds. 5 In addition, propolis contains minerals such as Mg, Ca, I, K, Na, Cu, Zn, Mn and Fe and some vitamins such as A, B1, B2, B6, C and E. 2 The biologically active substances of most types of propolis correspond to phenolic compounds, such as flavonoids (European propolis, derived from Populus species), prenylated phenylpropanoids (Brazilian green propolis, derived from Baccharis dracunculifolia) and polyprenylated benzophenonones (Venezuelan propolis, derived from Clusia species).…”

“…5 Therapeutic activities may occur through the synergism of these chemical compounds. 5 In addition, propolis contains minerals such as Mg, Ca, I, K, Na, Cu, Zn, Mn and Fe and some vitamins such as A, B1, B2, B6, C and E. 2 The biologically active substances of most types of propolis correspond to phenolic compounds, such as flavonoids (European propolis, derived from Populus species), prenylated phenylpropanoids (Brazilian green propolis, derived from Baccharis dracunculifolia) and polyprenylated benzophenonones (Venezuelan propolis, derived from Clusia species). The most produced Brazilian propolis is the green propolis, derived from Baccharis dracunculifolia (Asteraceae), its main constituents are prenylated phenylpropanoids and caffeoylquinic acids.…”

“…It is a disease with a multifactorial etiology, influenced by follicular hyperkeratinization, sebaceous hyperplasia, bacterial hypercolonization, immune reactions and inflammatory processes. 5,7 For acne treatment, topical products are widely used, whether or not associated with systemic medication. Often used keratolytics agents, alpha-hydroxy acids, benzoyl peroxide, retinoids, azelaic acid and antibiotics.…”