Autosomal dominant polycystic disease with associated arachnoid cysts and subdural cystic hygroma requiring shunting

Herman, T. E.; Siegel, Marilyn J.

doi:10.1038/jp.2010.67

Cited by 6 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, we detected arachnoid cysts in 12.8% of all examined Suisse ADPKD patients. Aside from several case reports [ 19 – 21 , 23 – 27 ], there are three analyses of ADPKD cohorts reporting a prevalence of arachnoid cysts which ranges from 5.2 to 8.1% ( Table 3 ) [ 13 , 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

Growth of arachnoid cysts in patients with autosomal dominant polycystic kidney disease: serial imaging and clinical relevance

Krauer

Ahmadli

Kollias

et al. 2012

Clinical Kidney Journal

View full text Add to dashboard Cite

BackgroundAutosomal dominant polycystic kidney disease (ADPKD) is an inherited disorder that results in the growth of cysts in the kidneys and other organs. Multisystemic involvement is common including affection of the central nervous system with cerebral aneurysms and arachnoid cysts.MethodsThis is a prospective cohort study to investigate the prevalence and growth rate of arachnoid cysts in ADPKD patients. Participants enrolled in the SUISSE ADPKD cohort were offered cranial imaging for the detection of intracranial alterations. In the case of identified arachnoid cysts, patients were suggested to undergo follow-up imaging to assess the growth rate of the cysts. Volume of arachnoid cysts at the baseline and at follow-up visits was assessed by manual segmentation on a dedicated workstation.ResultsA total of 109 ADPKD patients agreed to undergo cranial imaging. In 14 (12.8%) patients (9 males and 5 females), 18 singular arachnoid cysts were identified. The baseline volumes of individual cysts ranged from 1.8 to 337.6 cm3. During a mean follow-up period of 24 months, the volume changes of 12 individual arachnoid cysts of nine patients ranged from −3.1 to 3.7 cm3. Cystic lesions were mostly localized in the middle fossa. All affected patients were clinically asymptomatic.ConclusionsWe found a higher prevalence of arachnoid cysts in ADPKD patients with more advanced disease. There was a large variability in size and growth. These arachnoid cysts were clinically silent and their growth pattern was subtle and unpredictable, in contrast to the much more foreseeable growth of the renal cysts.

show abstract