Autoradiographische Untersuchungen zur Synthese von DNS, Kollagen und Mucopolysacchariden bei der experimentellen Proliferation der Aortenintima

Kunz, J; Kranz, D; Keim, O.

doi:10.1007/bf00960489

Cited by 15 publications

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other vascular systems studied included various forms of injury to arterioles. In a study of double stenosis of the aorta, Kunz et al (14) examined intimal cell proliferation and the uptake of isotopically-labeled thymidine or proline by the cells. They were not certain of the origin of the ceils in the proliferative lesions that they produced, although they suggested that the cells might be related to smooth muscle.…”

Section: Aortamentioning

confidence: 99%

The Smooth Muscle Cell

Ross

Klebanoff

1971

The Journal of Cell Biology

316

View full text Add to dashboard Cite

A B S T R A C TThese studies have examined the ability of smooth muscle cells from developing aorta of the prepubertal rat to utilize amino acids in the synthesis and secretion of connective tissue proteins. Prepubertal rats, previously given either an alcohol carrier or estradiol-17-beta, were each given an intravenous injection of proline-SH. The animals were sacrificed after 15 and 30 man, and 4 hr. Light and electron microscope radioautographs of the aortic smooth muscle and of the myometrial cells demonstrated that the aortic cells, in both groups of animals, and the myometrial cells, in the estrogen-stimulated animals, took up the proline and rapidly secreted it in both collagen and elastic fibers within 4 hr. In contrast, the myometrial cells of the nonstimulated animal took up relatively small amounts of proline and retained most of the amino acid within the cells. Electron microscope radioautographs demonstrated that the organelles involved in this activity were the rough endoplasmic reticulum and Golgi complex together with peripheral elements, presumed to be small vesicles. These studies have demonstrated that the smooth muscle cells of the developing aorta and of the estrogen-stimulated myometrinm have a capacity to synthesize and secrete proteins associated with the extracellular connective tissue matrix.

show abstract

Section: Aortamentioning

confidence: 99%