Autoradiographic Studies of the Distribution of 1-Aminocyclopentane Carboxylic Acid in Normal and Cancerous Mice

Berlinguet, Louis; Bégin, Nicole; Babineau, L. M.

doi:10.1139/y62-124

Cited by 12 publications

(7 citation statements)

References 3 publications

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“…These amino acids are primarily substrates for system L transport and have shown promising imaging properties in brain tumors. [151,152]. ACPC, also known as cycloleucine, has also been evaluated as a chemotherapeutic agent [153,154].…”

Section: Alicyclic Amino Acidsmentioning

confidence: 99%

Non-natural amino acids for tumor imaging using positron emission tomography and single photon emission computed tomography

McConathy

Goodman

2008

Cancer Metastasis Rev

109

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Amino acids are required nutrients for proliferating tumor cells, and amino acid transport is upregulated in many tumor types. Studies of radiolabeled amino acids in animals and humans demonstrate that amino acid based tracers have advantageous characteristics relative to 2-[(18)F]fluoro-2-deoxyglucose in certain tumors, particularly brain gliomas. Non-natural amino acids for tumor imaging generally have greater metabolic stability and can be labeled with longer-lived radionuclides for positron emission tomography and single photon emission computed tomography such as fluorine-18 and iodine-123. Amino acids enter cells via amino acid transport with varying selectivity based on their chemical structure. This review focuses on the rationale, biological basis, current status and future prospects of radiolabeled non-natural amino acids for tumor imaging and discusses various classes of these compounds including aromatic, alicyclic and alpha,alpha-dialkyl amino acids.

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Section: Alicyclic Amino Acidsmentioning

confidence: 99%

Non-natural amino acids for tumor imaging using positron emission tomography and single photon emission computed tomography

McConathy

Goodman

2008

Cancer Metastasis Rev

109

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“…Instead, two observers checked independently whether treated samples had (1) similar fluorescent pictures to those of control samples, or (2) wider distribution or higher density of DA than control samples, or (3) smaller distribution or lower density of DA than control samples. The data were adopted only when the two observers found similar results.…”

mentioning

confidence: 99%

Amines and the rat exocrine pancreas. 1. Effects of receptor blockers on turnover of L-dopa.

et al. 1979

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Abstract-The acinar cells of the exocrine pancreas have the capacity of efficiently take up and metabolize L-dopa. In the present study, the metabolism of L-dopa by the exocrine pancreas of the rat and effects of receptor blockers on the metabolism were studied by fluorescent histochemical and chemical methods. After i.v. administration of L-dopa (50 mg/kg), a large amount of dopamine (DA) was detected in the exocrine pancreas, and in the pancreatic juice large amounts of DA and its metabolites. DA blockers (haloperidol, sulpiride, and pimozide) and a-blockers (phenoxybenzamine, and phentolamine) produced a significant increase in the accumulation of DA after administration of L-dopa. On the other hand, (I-blockers (propranolol, and oxprenolol) were without effects. The excretion of DA into the pancreatic Juice appeared to be associated with the secretion of zymogen granules, thus DA serves as an indicator of pancreatic secretory activity, especially of enzyme secretion.Because DA and a blockers produced an increase in the accumulation of DA, dopaminergic and/or a adrenergic mechanisms probably exist in the exocrine pancreas of the rat and these mechanisms modify the enzyme secretion.The exocrine pancreas has a great capacity to take up amino acids and analogues of amino acids (1-5) from the blood, presumably reflecting the high protein synthesizing capacity of the organ. The exocrine pancreatic mechanism for the uptake and metabolism of amino acids L-dopa and L-5HTP has been studied (6-13). These amino acids are de carboxylated in the exocrine cells, and the corresponding amines can subsequently be me tabolized, probably mainly by oxidative deamination. These compounds are also taken up and transiently stored in the zymogen granules where they seem to be protected from enzymatic degradation. Reserpine, prenylamine, or desipramine prevented incorporation of DA into the pancreatic zymogen granules (14). These findings suggest that there are similarities, to sonic extent, between the exocrine pancreatic cells and the cells normally synthesizing and storing biogenic monoamines (i.e. adrenergic nerves and certain endocrine cell system).In sonic fluorescent histochernical experiments on the gastro-intestinal organs, we gave ra(s L-dopa and L-5HTP, and noticed that the fluorescence due to L-dopa and L-5HTPinjections was somewhat differently distributed in the exocrine pancreas.There is some possibility that L-dopa and L-5HTP are metabolized in a different manner by the exocrine pancreas, and a large amount of DA and 5-HT, accumulated intracellularly and extracellUlarly, could modify the exocrine pancreatic function. In the present experiments,

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“…Another amino acid which accumulates in the pancreas of mice, without being incorporated into proteins, is I-aminocyclopentane carboxylic acid (Berlinguet et al, 1962). Its pancreatic selectivity, however, is less pronounced than that of 4-iodophenylalanine.…”

Section: Discussionmentioning

confidence: 99%

“…Its pancreatic selectivity, however, is less pronounced than that of 4-iodophenylalanine. 1-Aminocyclopentane carboxylic acid is also concentrated by certain tumour tissues (Berlinguet et al, 1962).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Uptake of 125I-labelled 4-iodophenylalanine in tumours of mice.

Blomquist¹,

Flodh²,

Ullberg³

1969

Br J Cancer

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Autoradiographic Studies of the Distribution of 1-Aminocyclopentane Carboxylic Acid in Normal and Cancerous Mice

Cited by 12 publications

References 3 publications

Non-natural amino acids for tumor imaging using positron emission tomography and single photon emission computed tomography

Non-natural amino acids for tumor imaging using positron emission tomography and single photon emission computed tomography

Amines and the rat exocrine pancreas. 1. Effects of receptor blockers on turnover of L-dopa.

Uptake of 125I-labelled 4-iodophenylalanine in tumours of mice.

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