Uptake of 125I-labelled 4-iodophenylalanine in tumours of mice.

Blomquist, Lars; Flodh, H; Ullberg, Sven

doi:10.1038/bjc.1969.22

Cited by 8 publications

(2 citation statements)

References 3 publications

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“…present in the serum which are differentially taken up by tumor and normal cells 8. Since the elevated uptake of glucose and increased glycolitic activity of cancer cells has been first reported by Otto Warburg,9 it has been shown that in addition to glucose many molecules (amino acids, vitamins) are accumulated in cancer cells 10–12. The accumulation of these substances by cancer cells is utilized in positron emission tomography,13 and targeting strategies has been started to emerge on the basis of amino acid and vitamin accumulation 14, 15.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effect of tolerogenic dendritic cells in established collagen‐induced arthritis is associated with a reduction in Th17 responses

Stoop¹,

Harry²,

Delwig³

et al. 2010

Arthritis & Rheumatism

123

114

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Results. Tolerogenic DCs displayed a semimature phenotype, produced low levels of inflammatory cytokines, and exhibited low T cell stimulatory capacity. Upon intravenous injection into arthritic mice, tolerogenic DCs migrated to the spleen, liver, lung, feet, and draining lymph nodes. Treatment of arthritic mice with type II collagen-pulsed tolerogenic DCs, but not unpulsed tolerogenic DCs or mature DCs, significantly inhibited disease severity and progression. This improvement coincided with a significant decrease in the number of Th17 cells and an increase in the number of interleukin-10-producing CD4؉ T cells, whereas tolerogenic DC treatment had no detectable effect on Th1 cells or interleukin-17-producing ␥/␦ T cells.Conclusion. Treatment with type II collagenpulsed tolerogenic DCs decreases the proportion of Th17 cells in arthritic mice and simultaneously reduces the severity and progression of arthritis.

show abstract

Section: Introductionmentioning

confidence: 99%

Therapeutic effect of tolerogenic dendritic cells in established collagen‐induced arthritis is associated with a reduction in Th17 responses

Stoop¹,

Harry²,

Delwig³

et al. 2010

Arthritis & Rheumatism

123

114

View full text Add to dashboard Cite

show abstract

“…8 Since the elevated uptake of glucose and increased glycolitic activity of cancer cells has been first reported by Otto Warburg, 9 it has been shown that in addition to glucose many molecules (amino acids, vitamins) are accumulated in cancer cells. [10][11][12] The accumulation of these substances by cancer cells is utilized in positron emission tomography, 13 and targeting strategies has been started to emerge on the basis of amino acid and vitamin accumulation. 14,15 In recent years it became increasingly clear that there are a significant number of common signaling pathways regulating both cellular metabolism and cell proliferation.…”

Section: Introductionmentioning

confidence: 99%

A mixture of amino acids and other small molecules present in the serum suppresses the growth of murine and human tumors in vivo

Kulcsár¹,

Gaál

Kulcsár³

et al. 2012

Intl Journal of Cancer

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Previously we have hypothesized that the small molecules which are selectively accumulated in cancer cells might participate in a non-immunological antitumor surveillance mechanism. We demonstrated earlier that a mixture of experimentally selected substances (“active mixture”, AM: l-arginine, l-histidine, l-methionine, l-phenylalanine, l-tyrosine, l-tryptophan, l-ascorbate, d-biotin, pyridoxine, riboflavin, adenine, l(-)malate) possesses a selective toxic effect in vitro on a variety of tumor cell lines, and we have shown that the AM selectively induces apoptosis of cancer cells in vitro. To explore the in vivo significance of our earlier findings we examined the antitumor effect of AM in Colon 26 murine colorectal adenocarcinoma, B16 murine melanoma, MXT murine mammary carcinoma, S180 murine sarcoma, P388 murine lymphoid leukemia, HL-60 human promyeloid leukemia, PC-3 human prostate carcinoma, and HT-29 human colon carcinoma tumor models. Treatment of tumor bearing mice with AM inhibited the growth of the tumors investigated, with an inhibitory effect ranging from 40 to 69%. The AM had a comparable antitumor effect with 5-fluorouracil and cisplatin in the Colon-26 tumor model, and combined treatment with AM and 5-fluorouracil or cisplatin resulted in an enhanced tumor growth inhibitory effect. The AM induced apoptosis through the mitochondrial pathway and induced G1 arrest in PC-3 cells and increased the number of apoptotic cells in PC-3 xenografts. These findings suggest that the AM might offer an interesting perspective in the treatment of cancer and in combination with other treatments may offer hope for a more effective cancer therapy.

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Active mixture of serum-circulating small molecules selectively inhibits proliferation and triggers apoptosis in cancer cells via induction of ER stress

Scheffer¹,

Kulcsár²,

Nagyéri

et al. 2020

Cellular Signalling

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Uptake of 125I-labelled 4-iodophenylalanine in tumours of mice.

Abstract: Images Fig. 1

Cited by 8 publications

References 3 publications

Therapeutic effect of tolerogenic dendritic cells in established collagen‐induced arthritis is associated with a reduction in Th17 responses

Therapeutic effect of tolerogenic dendritic cells in established collagen‐induced arthritis is associated with a reduction in Th17 responses

A mixture of amino acids and other small molecules present in the serum suppresses the growth of murine and human tumors in vivo

Active mixture of serum-circulating small molecules selectively inhibits proliferation and triggers apoptosis in cancer cells via induction of ER stress

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