Autoradiographic localization of receptors for glucagon-like peptide-1(7–36) amide in rat brain

Uttenthal, L. O.; Toledano, A; Blázquez, Enrique

doi:10.1016/0143-4179(92)90036-v

Cited by 80 publications

(39 citation statements)

References 24 publications

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“…So, although c-FL1 in a region does not necessarily imply that there is a direct action of the treatment on that region of the CNS, the present data are consistent with a receptor-mediated role for leptin in the integration of food intake and body weight in hypothalamus and possibly limbic regions as well. Messenger RNA transcripts encoding for preproglucagon precursors have been found in the NTS (6), and GLP-1 binding sites have been localized in many brain areas, including those that expressed GLP-l-induced c-FL1 in the present experiment (4,24,28). Thus it is possible that GLP-1 is involved in relaying visceral information at the level of the NTS and that secondary ascending fiber systems projecting from the NTS activate the c-FLI-positive areas identified in the present study (14).…”

Section: Discussionmentioning

confidence: 99%

Central infusions of leptin and GLP-1-(7-36) amide differentially stimulate c-FLI in the rat brain

Dijk

Thiele

Donahey

et al. 1996

American Journal of Physiology-Regulatory, Integrative and Comp

102

103

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Section: Discussionmentioning

confidence: 99%

Central infusions of leptin and GLP-1-(7-36) amide differentially stimulate c-FLI in the rat brain

Dijk

Thiele

Donahey

et al. 1996

American Journal of Physiology-Regulatory, Integrative and Comp

102

103

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“…Moreover, GLP-1 receptors are also expressed in the area postrema of the rat brain, which could interact with circulating GLP-1 (27,28). In our experimental procedure, hyperglycemia was induced by a systemic glucose infusion; therefore, under these conditions, GLP-1 secretion from the gut is not increased.…”

Section: Discussionmentioning

confidence: 99%

Brain Glucagon-Like Peptide-1 Regulates Arterial Blood Flow, Heart Rate, and Insulin Sensitivity

et al. 2008

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OBJECTIVE-To ascertain the importance and mechanisms underlying the role of brain glucagon-like peptide (GLP)-1 in the control of metabolic and cardiovascular function. GLP-1 is a gut hormone secreted in response to oral glucose absorption that regulates glucose metabolism and cardiovascular function. GLP-1 is also produced in the brain, where its contribution to central regulation of metabolic and cardiovascular homeostasis remains incompletely understood.RESEARCH DESIGN AND METHODS-Awake free-moving mice were infused with the GLP-1 receptor agonist exendin-4 (Ex4) into the lateral ventricle of the brain in the basal state or during hyperinsulinemic eu-/hyperglycemic clamps. Arterial femoral blood flow, whole-body insulin-stimulated glucose utilization, and heart rates were continuously recorded. RESULTS-A continuous 3-h brain infusion of Ex4 decreasedfemoral arterial blood flow and whole-body glucose utilization in the awake free-moving mouse clamped in a hyperinsulinemichyperglycemic condition, only demonstrating that this effect was strictly glucose dependent. However, the heart rate remained unchanged. The metabolic and vascular effects of Ex4 were markedly attenuated by central infusion of the GLP-1 receptor (GLP-1R) antagonist exendin-9 (Ex9) and totally abolished in GLP-1 receptor knockout mice. A correlation was observed between the metabolic rate and the vascular flow in control and Ex4-infused mice, which disappeared in Ex9 and GLP-1R knockout mice. Moreover, hypothalamic nitric oxide synthase activity and the concentration of reactive oxygen species (ROS) were also reduced in a GLP-1R-dependent manner, whereas the glutathione antioxidant capacity was increased. Central GLP-1 activated vagus nerve activity, and complementation with ROS donor dose-dependently reversed the effect of brain GLP-1 signaling on peripheral blood flow.CONCLUSIONS-Our data demonstrate that central GLP-1 signaling is an essential component of circuits integrating cardiovascular and metabolic responses to hyperglycemia.

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“…The anorexigenic effects of GLP-1 and OXM are blocked by the antagonist, exendin(9-39), when administered centrally (Turton et al 1996, Dakin et al 2001. GLP-1 receptors are present in both the NTS and hypothalamus (Uttenthal et al 1992, Shughrue et al 1996, and are also widespread in the periphery: in the pancreas, lung, brain, kidney, gastrointestinal tract and heart (Wei & Mojsov 1995, Bullock et al 1996.…”

Section: Proglucagon Productsmentioning

confidence: 99%

Appetite control

Wynne¹,

Stanley²,

McGowan³

et al. 2005

Journal of Endocrinology

473

403

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Our understanding of the physiological systems that regulate food intake and body weight has increased immensely over the past decade. Brain centres, including the hypothalamus, brainstem and reward centres, signal via neuropeptides which regulate energy homeostasis. Insulin and hormones synthesized by adipose tissue reflect the long-term nutritional status of the body and are able to influence these circuits. Circulating gut hormones modulate these pathways acutely and result in appetite stimulation or satiety effects. This review discusses central neuronal networks and peripheral signals which contribute energy homeostasis, and how a loss of the homeostatic process may result in obesity. It also considers future therapeutic targets for the treatment of obesity.

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Autoradiographic localization of receptors for glucagon-like peptide-1(7–36) amide in rat brain

Cited by 80 publications

References 24 publications

Central infusions of leptin and GLP-1-(7-36) amide differentially stimulate c-FLI in the rat brain

Central infusions of leptin and GLP-1-(7-36) amide differentially stimulate c-FLI in the rat brain

Brain Glucagon-Like Peptide-1 Regulates Arterial Blood Flow, Heart Rate, and Insulin Sensitivity

Appetite control

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