Autoradiographic detection of vasopressin binding sites, but not of oxytocin binding sites, in the sheep olfactory bulb

Lévy, F.; Dreifuss, Jean Jacques; Dubois‐Dauphin, Michel; Berti, Marina; Barberis, Claude; Tribollet, Eliane

doi:10.1016/0006-8993(92)91467-s

Cited by 13 publications

(2 citation statements)

References 33 publications

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“…Additionally, glia in the olfactory bulb displayed ir to VIM, an indicator of tanycytes (Chauvet et al, ). Of interest is that V1aR mRNA was found in the internal granular cell layer of the main olfactory bulb of rats (Ostrowski et al, ), and [ 3 H]vasopressin receptor binding was reported for the olfactory bulb of sheep (Levy et al, ) and guinea pigs (Tribollet et al, ). Peripherally administered protein (Balin et al, ) and peroxidase‐conjugated wheat germ agglutinin (Baker and Spencer, ) have been shown to enter the brain via the olfactory bulb.…”

Section: Discussionmentioning

confidence: 99%

Distribution of the vasotocin type 4 receptor throughout the brain of the chicken, Gallus gallus

Selvam

Jurkevich

Kuenzel

2014

J of Comparative Neurology

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The vasopressin 1a receptor (V1aR) has been shown to have a wide distribution throughout the mammalian brain and pituitary gland and mediates a number of physiological functions as well as social behavior following the binding of its agonist, vasopressin. The avian receptor homologous to the V1aR is the vasotocin 4 receptor (VT4R). Its mRNA distribution has been documented in brain regions of two species of songbird; however, its complete protein distribution in the brain has not been published to date for any avian species. The present work utilizes an antibody made to a sequence of the chicken VT4R to map its distribution from the olfactory bulbs to the caudal end of the brainstem in Gallus gallus. Unexpectedly, immunoreactivity (ir) for the VT4R was found not only in neurons but also in glia located in 10 circumventricular organs (CVOs), olfactory bulbs, hippocampus, and septum. Use of a second antibody made against vimentin provided evidence that some dual-labeled glial cells were tanycytes and radial glia. Additionally, the VT4R was identified in nuclei related to motor function, including the oculomotor complex and motor nucleus of the fourth, fifth, sixth, seventh, tenth, and twelfth cranial nerves. Possible functions for the VT4R are suggested that should have relevance not only to avian species but to other vertebrates because most classes, except for mammals, use vasotocin as the natural ligand for that receptor.

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Section: Discussionmentioning

confidence: 99%

Distribution of the vasotocin type 4 receptor throughout the brain of the chicken, Gallus gallus

Selvam

Jurkevich

Kuenzel

2014

J of Comparative Neurology

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“…Similarly, female prairie and montane voles have significantly greater Oxtr binding in the VMH than virgin females or males, although the expression patterns differ between the two species (Wang et al , 2000). Interestingly, specific Oxtr binding sites have not been found in the OB of postpartum ewes (Levy et al , 1992), despite an increase in Oxt levels in the same region (Levy et al , 1995). …”

Section: Behaviormentioning

confidence: 98%

Oxytocin: The Great Facilitator of Life

Lee

Macbeth

Pagani

et al. 2009

Progress in Neurobiology

635

634

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Oxytocin (Oxt) is a nonapeptide hormone best known for its role in lactation and parturition. Since 1906 when its uterine-contracting properties were described until 50 years later when its sequence was elucidated, research focused on its peripheral roles in reproduction. Only over the past several decades have researchers focused on what functions Oxt might have in the brain, the subject of this review. Immunohistochemical studies revealed that magnocellular neurons of the hypothalamic paraventricular and supraoptic nuclei are the neurons of origin for the Oxt released from the posterior pituitary. Smaller cells in various parts of the brain, as well as release from magnocellular dendrites, provide the Oxt responsible for modulating various behaviors at its only identified receptor. Although Oxt is implicated in a variety of “non-social” behaviors, such as learning, anxiety, feeding and pain perception, it is Oxt’s roles in various social behaviors that have come to the fore recently. Oxt is important for social memory and attachment, sexual and maternal behavior, and aggression. Recent work implicates Oxt in human bonding and trust as well. Human disorders characterized by aberrant social interactions, such as autism and schizophrenia, may also involve Oxt expression. Many, if not most, of Oxt’s functions, from social interactions (affiliation, aggression) and sexual behavior to eventual parturition, lactation and maternal behavior, may be viewed as specifically facilitating

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Oxytocin and vasopressin release in the olfactory bulb of parturient ewes: changes with maternal experience and effects on acetylcholine, γ-aminobutyric acid, glutamate and noradrenaline release

et al. 1995

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Autoradiographic detection of vasopressin binding sites, but not of oxytocin binding sites, in the sheep olfactory bulb

Cited by 13 publications

References 33 publications

Distribution of the vasotocin type 4 receptor throughout the brain of the chicken, Gallus gallus

Distribution of the vasotocin type 4 receptor throughout the brain of the chicken, Gallus gallus

Oxytocin: The Great Facilitator of Life

Oxytocin and vasopressin release in the olfactory bulb of parturient ewes: changes with maternal experience and effects on acetylcholine, γ-aminobutyric acid, glutamate and noradrenaline release

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