2018
DOI: 10.18632/aging.101586
View full text |Buy / Rent full text
|
Sign up to set email alerts
|

Abstract: The development of diabetic encephalopathy (DE) is enhanced by inflammatory macrophages, and is suppressed by macrophage autophagy. However, the molecular signaling that controls macrophage autophagy in DE remains ill-defined. Here, DE is induced in rats that received intraperitoneal injection of streptozotocin (STZ). In macrophages isolated from the brain of the rats, we detected downregulated autophagy activity and enhanced PI3k/Akt/mTOR/S6K1 signaling. In order to examine the role of autophagy and PI3k/Akt/… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
18
0

Year Published

2019
2019
2021
2021

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 29 publications
(18 citation statements)
references
References 28 publications
(27 reference statements)
0
18
0
Order By: Relevance
“…It has been demonstrated that PI3K/Akt/autophagy pathway is closely related to the regulation of cells migration and angiogenesis . The results also indicated the down‐regulation and up‐regulation of PI3K and Akt phosphorylation were found in EPCs with miR‐9‐5p mimics and inhibitor, respectively (Figure 5).…”
Section: Resultsmentioning
confidence: 86%
“…It has been demonstrated that PI3K/Akt/autophagy pathway is closely related to the regulation of cells migration and angiogenesis . The results also indicated the down‐regulation and up‐regulation of PI3K and Akt phosphorylation were found in EPCs with miR‐9‐5p mimics and inhibitor, respectively (Figure 5).…”
Section: Resultsmentioning
confidence: 86%
“…Moreover, it is common knowledge that as an upstream pathway, the PI3K/Akt/mTOR signal is critical for the regulation of autophagy. [30, 31, 32] But the function of CaSR and PI3K/Akt/mTOR in HPASMCs of hypoxic cell models has not been discussed. In the current study, we first found that the inhibition of the PI3K/Akt/mTOR pathway is critical for the inhibition of hypoxia-induced autophagy by NPS2390.…”
Section: Discussionmentioning
confidence: 99%
“…Homocysteine, an amino acid metabolite, regulates the connection between mTOR and lysosomal membranes and can inhibit autophagy through activating mTORC1 in vitro and in vivo [ 196 ]. PI3K/Akt/mTOR signaling regulated autophagy in macrophages in the development of diabetic encephalopathy and, in particular, chondrocytes by inhibiting miR-20 in osteoarthritis [ 44 , 45 ]. Curcumin, used in Indian and Chinese medicine as a wound-healing agent, among other uses, can also have a beneficial effect on osteoarthritis by possibly enhancing autophagy and reducing cell death and cartilage loss via Akt/mTOR signaling [ 197 ].…”
Section: Mtor Signalingmentioning
confidence: 99%