volume 10, issue 10, P2772-2782 2018
DOI: 10.18632/aging.101586
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Beiyun Wang, Yuan Zhong, Qinjie Li, Liang Cui, Gaozhong Huang

Abstract: The development of diabetic encephalopathy (DE) is enhanced by inflammatory macrophages, and is suppressed by macrophage autophagy. However, the molecular signaling that controls macrophage autophagy in DE remains ill-defined. Here, DE is induced in rats that received intraperitoneal injection of streptozotocin (STZ). In macrophages isolated from the brain of the rats, we detected downregulated autophagy activity and enhanced PI3k/Akt/mTOR/S6K1 signaling. In order to examine the role of autophagy and PI3k/Akt/…

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