Autophagy modulation in animal models of corneal diseases: a systematic review

Martínez-Chacón, Guadalupe; Vela, Francisco Javier; Campos, Jose; Abellán, E. Doménech; Yakhine-Diop, Sokhna M. S.; Ballestín, Alberto

doi:10.1007/s11010-020-03832-5

Cited by 5 publications

(3 citation statements)

References 89 publications

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“…Importantly, we demonstrated that Col8a2 Q455K/Q455K and Col8a2 L450W/L450W mice, which recapitulate features of early-onset FECD including guttae and endothelial pleomorphism ( Jun et al, 2012 ; Meng et al, 2013 ), had softer DMs that preceded endothelial cell loss ( Leonard et al, 2023 ). Furthermore, this model demonstrates endoplasmic reticulum stress, unfolded protein response and altered autophagy critical in the pathogenesis of FECD ( Martínez-Chacón et al, 2020 ; Meng et al, 2013 ). Mechanotransduction and autophagy are highly interconnected and regulate each other in a process known as mechanoautophagy ( Ravasio et al, 2022 ).…”

Section: Corneal Endotheliummentioning

confidence: 89%

Squishy matters – Corneal mechanobiology in health and disease

Thomasy,

Leonard,

Greiner

et al. 2024

Progress in Retinal and Eye Research

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Section: Corneal Endotheliummentioning

confidence: 89%

Squishy matters – Corneal mechanobiology in health and disease

Thomasy,

Leonard,

Greiner

et al. 2024

Progress in Retinal and Eye Research

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“…[ 35 ] In animal models, autophagy modulators were used in various routes of administration for the treatment of DED. [ 51 ] Interestingly, anti-inflammatory agents like cyclosporine and lifitegrast shown to have a role in autophagy and inflammation in dry patients [ Fig. 5 ].…”

Section: Autophagy Modulators In Dry Eye Disease-associated Stressmentioning

confidence: 99%

Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface

Jeyabalan

Pillai²,

Khamar³

et al. 2023

Indian Journal of Ophthalmology

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Dry eye disease (DED) is a chronic ocular surface disorder, associated with inflammation, which can cause severe morbidity, visual compromise, and loss of quality of life, affecting up to 5–50% of the world population. In DED, ocular surface damage and tear film instability due to abnormal tear secretion lead to ocular surface pain, discomfort, and epithelial barrier disruption. Studies have shown the involvement of autophagy regulation in dry eye disease as a pathogenic mechanism along with the inflammatory response. Autophagy is a self-degradation pathway in mammalian cells that reduces the excessive inflammation driven by the secretion of inflammatory factors in tears. Specific autophagy modulators are already available for the management of DED currently. However, growing studies on autophagy regulation in DED might further encourage the development of autophagy modulating drugs that reduce the pathological response at the ocular surface. In this review, we summarize the role of autophagy in the pathogenesis of dry eye disease and explore its therapeutic application.

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“…The inhibition of autophagy can inhibit the formation of neovascularization induced by VEGF [ 104 ]. Dysfunctional autophagy is implicated in corneal diseases such as granular corneal dystrophy type 2, keratoconus, dry eye, and Schnyder corneal dystrophy [ 9 , 125 , 126 , 127 ]. Keratocytes in the stroma play a significant role in corneal repair by producing myofibroblasts through several cytokines, growth factors, and extracellular matrix (ECM) components.…”

Section: Dysregulated or Delayed Autophagy And Its Late Effectsmentioning

confidence: 99%

Autophagy in Extracellular Matrix and Wound Healing Modulation in the Cornea

Kempuraj

Mohan

2022

Biomedicines

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Autophagy is a robust cellular mechanism for disposing of harmful molecules or recycling them to cells, which also regulates physiopathological processes in cornea. Dysregulated autophagy causes inefficient clearance of unwanted proteins and cellular debris, mitochondrial disorganization, defective inflammation, organ dysfunctions, cell death, and diseases. The cornea accounts for two-thirds of the refraction of light that occurs in the eyes, but is prone to trauma/injury and infection. The extracellular matrix (ECM) is a noncellular dynamic macromolecular network in corneal tissues comprised of collagens, proteoglycans, elastin, fibronectin, laminins, hyaluronan, and glycoproteins. The ECM undergoes remodeling by matrix-degrading enzymes and maintains corneal transparency. Autophagy plays an important role in the ECM and wound healing maintenance. Delayed/dysregulated autophagy impacts the ECM and wound healing, and can lead to corneal dysfunction. Stromal wound healing involves responses from the corneal epithelium, basement membrane, keratocytes, the ECM, and many cytokines and chemokines, including transforming growth factor beta-1 and platelet-derived growth factor. Mild corneal injuries self-repair, but greater injuries lead to corneal haze/scars/fibrosis and vision loss due to disruptions in the ECM, autophagy, and normal wound healing processes. Presently, the precise role of autophagy and ECM remodeling in corneal wound healing is elusive. This review discusses recent trends in autophagy and ECM modulation in the context of corneal wound healing and homeostasis.

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Autophagy modulation in animal models of corneal diseases: a systematic review

Cited by 5 publications

References 89 publications

Squishy matters – Corneal mechanobiology in health and disease

Squishy matters – Corneal mechanobiology in health and disease

Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface

Autophagy in Extracellular Matrix and Wound Healing Modulation in the Cornea

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