Autophagy is involved in regulating the immune response of dendritic cells to influenza A (H1N1) pdm09 infection

Abstract

SummaryAutophagy can mediate antiviral immunity. However, it remains unknown whether autophagy regulates the immune response of dendritic cells (DCs) to influenza A (H1N1) pdm09 infection. In this study, we found that infection with the H1N1 virus induced DC autophagy in an endocytosis-dependent manner. Compared with autophagy-deficient Beclin-1 +/À mice, we found that bone-marrow-derived DCs from wild-type mice (WT BMDCs) presented a more mature phenotype on H1N1 infection. Wildtype BMDCs secreted higher levels of interleukin-6 (IL-6), tumour necrosis factor-a ( Our data indicate that autophagy is important in the regulation of the DC immune response to H1N1 infection, thereby extending our understanding of host immune responses to the virus.

Palmitic acid stimulates interleukin‐8 via the TLR4/NF‐κB/ROS pathway and induces mitochondrial dysfunction in bovine oviduct epithelial cells

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“…Interestingly, dendritic cells from autophagy-deficient Beclin-1 (+/-) mice secreted lower levels of proinflammatory cytokines than those from wild-type mice. 34 In general, autophagy blocks the induction of apoptosis, and apoptosis-associated caspase activation shuts off the autophagic process. 35 We showed that pre-treatment with bafilomycin A1 sensitized OECs to PA-induced cell death.…”

Inhibition of H1N1 influenza virus by selenium nanoparticles loaded with zanamivir through p38 and JNK signaling pathways

“…6B, expressions of p-JNK and p-p38 raised in untreated H1N1 infection group, consistent with the previous report. 51 But both the expression evidently decreased aer treated with Se@ZNV. The…”

Nonstructural protein 6 of porcine epidemic diarrhea virus induces autophagy to promote viral replication via the PI3K/Akt/mTOR axis

“…Autophagy plays important roles in modulating viral replication and antiviral immune response (McFarlane et al, 2011;Mohl et al, 2012;Monastyrska et al, 2013;Paul and Munz, 2016;Radtke et al, 2013). Increasing evidence indicates that autophagy plays both anti-viral and pro-viral roles in the life cycles and pathogenesis of a wide range of viruses (Chiramel et al, 2013;Jackson, 2015;Zang et al, 2016). Previous studies have shown that coronavirus infection is associated with the autophagic process, and that the nonstructural proteins of coronavirus induce the formation of autophagosomes from the endoplasmic reticulum via an omegasome intermediate (Cottam et al, 2011).…”