Autophagy inhibition enabled efficient photothermal therapy at a mild temperature

Zhou, Zhong; Yang, Yan; Hu, Kewen; Zou, Yuan; Li, Yiwen; Ma, Rui; Zhang, Qiang; Cheng, Yiyun

doi:10.1016/j.biomaterials.2017.06.030

Cited by 147 publications

(98 citation statements)

References 52 publications

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“…Very recently, Cheng's group demonstrated the application of these PDA–Fe 3+ as biomarkers for tracking PDA distribution in vivo. [ 39 ] They intravenously injected PDA–Fe 3+ (5.3% Fe 3+ by mass) to tumor‐bearing mice. The ICP‐MS analysis revealed the accumulation of PDA in the tumors even after 24 h. It is worth to note that this experiment can be only accomplished by high Fe 3+ loading sample due to the existing Fe 3+ background in organs.…”

Section: Fabrication and Characterization Of Mpdamentioning

confidence: 99%

“…The ICP‐MS analysis revealed the accumulation of PDA in the tumors even after 24 h. It is worth to note that this experiment can be only accomplished by high Fe 3+ loading sample due to the existing Fe 3+ background in organs. [ 39a ] Due to the high metal loading, this type of nanomaterials has also been extensively used to provide the metal source for metal oxides hybrids as nonprecious metal electrocatalysts. [ 20a,30 ]…”

Section: Fabrication and Characterization Of Mpdamentioning

confidence: 99%

“…Beside MRI, the high Fe 3+ concentration of these MPDA can be used as the marker to track the biodistribution of PDA by ICP‐MS. [ 39 ] Besides PDA‐M n + , PDA‐M x O y has also been used as MRI contrast agents. [ 17c,64,65 ] The PDA coating not only provided high colloidal stability but also allowed the surface functionalization of graphene quantum dot for photodynamic therapy.…”

Section: Application Of Mpda In Theranosticsmentioning

confidence: 99%

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Metal‐Containing Polydopamine Nanomaterials: Catalysis, Energy, and Theranostics

Wang

Zou

et al. 2020

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Polydopamine (PDA) is a major type of artificial melanin material with many interesting properties such as antioxidant activity, free‐radical scavenging, high photothermal conversion efficiency, and strong metal‐ion chelation. The high affinity of PDA to a wide range of metals/metal ions has offered a new class of functional metal‐containing polydopamine (MPDA) nanomaterials with promising functions and extensive applications. Understanding and controlling the metal coordination environment is vital to achieve desirable functions for which such materials can be exploited. MPDA nanomaterials with metal/metal ions as the active functions are reviewed, including their synthesis and metal coordination environment and their applications in catalysis, batteries, solar cells, capacitors, medical imaging, cancer therapy, antifouling, and antibacterial coating. The current trends, limitations, and future directions of this area are also explored.

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Section: Fabrication and Characterization Of Mpdamentioning

confidence: 99%

Section: Fabrication and Characterization Of Mpdamentioning

confidence: 99%

Section: Application Of Mpda In Theranosticsmentioning

confidence: 99%

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Metal‐Containing Polydopamine Nanomaterials: Catalysis, Energy, and Theranostics

Wang

Zou

et al. 2020

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218

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“…[14][15][16] However, autophagy is intensely activated by physiological stimuli or stress, including starvation, oxidation, PTT and chemotherapy. [17][18][19] Through degrading damaged organelles and misfolded proteins in autophagosomes, autophagy plays a vital role in maintaining the intracellular homeostasis. 20 PTT generates local heat and causes stress metabolite accumulation, by which the autophagy pathway was triggered.…”

Section: Introductionmentioning

confidence: 99%

<p>Gallbladder Cancer Progression Is Reversed by Nanomaterial-Induced Photothermal Therapy in Combination with Chemotherapy and Autophagy Inhibition</p>

Cai¹,

Wang²,

Wang³

et al. 2020

IJN

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Introduction: Gallbladder cancer (GBC) is the most common malignancy in biliary tract with extremely poor prognosis. Photothermal therapy (PTT) shows great promises for tumor therapy, which causes tumor cell death via selectively directed heating released by nanoparticles under the near-infrared irradiation. Through degrading damaged organelles and misfolded proteins in autophagosomes, autophagy plays a vital role in maintaining the intracellular homeostasis. The present study attempted to combine chemotherapy and autophagy blocking with PTT. Materials and Methods: We purchased multi-walled carbon nanotubes from Nanostructured and Amorphous Materials and performed PTT using an 808-nm diode laser. The cytotoxic effects of PTT and chemotherapy in vitro were assessed by cell viability analysis. The effects of PTT and chemotherapy on autophagy in vitro were assessed by GFP-LC3 and Western blot. And these results were confirmed by in vivo experiment. Results: Both PTT and chemotherapy could trigger cytoprotective autophagy to tolerate the cellular stresses and prolong the survival of GBC cell; therefore, the blocking of autophagy could enhance the efficacy of PTT and chemotherapy in GBC treatment in vitro and in vivo. Conclusion: Chemotherapeutic drug doxorubicin and autophagy inhibitor chloroquine could enhance the efficacy of nanoparticle-mediated hyperthermia in GBC.

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“…Hence, the inhibition of autophagy opens up the possibilities of enhancing the efficacy of photothermal ablation of cancer cells. Although the effect of autophagy inhibitors on enhancing PTT‐mediated tumor killing has recently been reported, the exact mechanism has not been well elucidated. In addition, multiple rounds and high doses of irradiation during the treatment may increase the long‐term risk of irradiation‐induced normal tissue injury and other cancers.…”

Section: Introductionmentioning

confidence: 99%

A Cascade‐Targeting Nanocapsule for Enhanced Photothermal Tumor Therapy with Aid of Autophagy Inhibition

Wang

et al. 2018

Adv Healthcare Materials

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Autophagy is a homeostatic lysosome-dependent metabolic process to eliminate damaged or dysfunctional cellular organelles, which is closely associated with tumor progression. Indocyanine green (ICG) can convert NIR light energy to localized heat for cancer cell and tissue ablation. However, the effect of autophagy modulation on ICG-mediated photothermal therapy remains unknown. In this study, it is found that primaquine (PQ) suppresses autophagy flux at a late stage through the impeding fusion of the autophagosome with the lysosome to form an autophagolysosome, leading to cell apoptosis or necrosis. This autophagosome-lysosome fusion inhibitory effect and the autophagosome accumulation are more evident in the photothermal therapy combined with autophagy inhibition. Motivated by this notable effect, a cascade-targeting nanocapsule (HCP) is constructed using an organic solvent-free strategy to coencapsulate PQ and ICG. By targeting the cluster designation 44 molecule and sequentially enhancing the cell-penetrating peptide-mediated endocytosis, the codelivery of PQ/ICG by HCP achieves selective recognition and reinforces the internalization by MCF-7 cells to exert a synergistic therapeutic effect on MCF-7 cells both in vitro and in vivo. The HCP system for the photothermal and autophagy inhibition combination therapy represents a novel strategy for the treatment of breast cancer.

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Autophagy inhibition enabled efficient photothermal therapy at a mild temperature

Cited by 147 publications

References 52 publications

Metal‐Containing Polydopamine Nanomaterials: Catalysis, Energy, and Theranostics

Metal‐Containing Polydopamine Nanomaterials: Catalysis, Energy, and Theranostics

<p>Gallbladder Cancer Progression Is Reversed by Nanomaterial-Induced Photothermal Therapy in Combination with Chemotherapy and Autophagy Inhibition</p>

A Cascade‐Targeting Nanocapsule for Enhanced Photothermal Tumor Therapy with Aid of Autophagy Inhibition

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