Autophagy in the Lifetime of Plants: From Seed to Seed

Wang, S; Hu, Weiming; Liu, Fen

doi:10.3390/ijms231911410

Cited by 9 publications

(16 citation statements)

References 119 publications

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“…The first level of defense involves the induction of transmembrane pattern-recognition receptors of the host plant that distinguish microorganism molecular signatures: microbe-associated molecular patterns (MAMPs) and pathogen-associated molecular patterns (PAMPs) [ 6 ]. Commonly occurring bacterial MAMPs include flagellin, surface polysaccharides, lipopolysaccharides, and exopolysaccharides [ 6 , 13 , 14 ].…”

Section: Autophagy Pathway Role and Regulationmentioning

confidence: 99%

“…A pattern-triggered immunity reaction includes the production of peroxidases, activated oxygen species, changes in calcium concentration, and modulation of defense through the activity of transcriptional regulators. Defense mechanisms at the level of the plant organism are manifested as stomatal closure, cell-wall strengthening, and the production of antimicrobial compounds [ 14 ]. The pathogens are able to retaliate the plant defense reactions and to suppress host immunity by secreting effectors via the bacterial type III secretion system (T3SS) [ 15 ] into the plant cell or the apoplast [ 16 ].…”

Section: Autophagy Pathway Role and Regulationmentioning

confidence: 99%

“…Another type of autophagy in plant cells, mega-autophagy, is the cell autolysis and degradation during the process of programmed cell death (PCD) [ 12 , 13 ]. For a detailed description of autophagy regulatory processes in plants, we recommend several excellent reviews [ 10 , 11 , 12 , 13 , 14 ].…”

Section: Autophagy-related Genes and Autophagosomementioning

confidence: 99%

“…The TOR complex is a sensor of the nutritional status of the cell and at the same time a negative regulator of autophagy. It consists of the kinase TOR, RAPTOR (regulatory-associated protein of TOR) that promotes complex stabilization and substrate recognition, and the regulatory subunit LST8 [ 13 , 14 ].…”

Section: Autophagy-related Genes and Autophagosomementioning

confidence: 99%

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Autophagy and Symbiosis: Membranes, ER, and Speculations

Semenova,

Petina,

Fedorova

2024

IJMS

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The interaction of plants and soil bacteria rhizobia leads to the formation of root nodule symbiosis. The intracellular form of rhizobia, the symbiosomes, are able to perform the nitrogen fixation by converting atmospheric dinitrogen into ammonia, which is available for plants. The symbiosis involves the resource sharing between two partners, but this exchange does not include equivalence, which can lead to resource scarcity and stress responses of one of the partners. In this review, we analyze the possible involvement of the autophagy pathway in the process of the maintenance of the nitrogen-fixing bacteria intracellular colony and the changes in the endomembrane system of the host cell. According to in silico expression analysis, ATG genes of all groups were expressed in the root nodule, and the expression was developmental zone dependent. The analysis of expression of genes involved in the response to carbon or nitrogen deficiency has shown a suboptimal access to sugars and nitrogen in the nodule tissue. The upregulation of several ER stress genes was also detected. Hence, the root nodule cells are under heavy bacterial infection, carbon deprivation, and insufficient nitrogen supply, making nodule cells prone to autophagy. We speculate that the membrane formation around the intracellular rhizobia may be quite similar to the phagophore formation, and the induction of autophagy and ER stress are essential to the success of this process.

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Section: Autophagy Pathway Role and Regulationmentioning

confidence: 99%

Section: Autophagy Pathway Role and Regulationmentioning

confidence: 99%

Section: Autophagy-related Genes and Autophagosomementioning

confidence: 99%

Section: Autophagy-related Genes and Autophagosomementioning

confidence: 99%

See 2 more Smart Citations

Autophagy and Symbiosis: Membranes, ER, and Speculations

Semenova,

Petina,

Fedorova

2024

IJMS

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“…Autophagy is a highly conserved self-degradation mechanism for eukaryotes ( Nakatogawa, 2020 ; Wang S. et al., 2022 ). The autophagy process can be divided into distinct stages including induction, cargo recognition, phagophore formation, phagophore expansion and closure, and autophagosome fusion with vacuole and breakdown of the inclusion ( Nakatogawa, 2020 ; Su et al., 2020 ).…”

Section: An Overview Of the Vesicle Trafficking Networkmentioning

confidence: 99%

Vesicle trafficking in rice: too little is known

Zhu,

Yin,

Guo

et al. 2023

Front. Plant Sci.

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The vesicle trafficking apparatus is a fundamental machinery to maintain the homeostasis of membrane-enclosed organelles in eukaryotic cells. Thus, it is broadly conserved in eukaryotes including plants. Intensive studies in the model organisms have produced a comprehensive picture of vesicle trafficking in yeast and human. However, with respect to the vesicle trafficking of plants including rice, our understanding of the components and their coordinated regulation is very limited. At present, several vesicle trafficking apparatus components and cargo proteins have been identified and characterized in rice, but there still remain large unknowns concerning the organization and function of the rice vesicle trafficking system. In this review, we outline the main vesicle trafficking pathways of rice based on knowledge obtained in model organisms, and summarize current advances of rice vesicle trafficking. We also propose to develop methodologies applicable to rice and even other crops for further exploring the mysteries of vesicle trafficking in plants.

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The emerging roles of miRNA-mediated autophagy in ovarian cancer

Ding,

Huang,

et al. 2024

Cell Death Dis

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Ovarian cancer is one of the common tumors of the female reproductive organs. It has a high mortality rate, is highly heterogeneous, and early detection and primary prevention are very complex. Autophagy is a cellular process in which cytoplasmic substrates are targeted for degradation in lysosomes through membrane structures called autophagosomes. The periodic elimination of damaged, aged, and redundant cellular molecules or organelles through the sequential translation between amino acids and proteins by two biological processes, protein synthesis, and autophagic protein degradation, helps maintain cellular homeostasis. A growing number of studies have found that autophagy plays a key regulatory role in ovarian cancer. Interestingly, microRNAs regulate gene expression at the posttranscriptional level and thus can regulate the development and progression of ovarian cancer through the regulation of autophagy in ovarian cancer. Certain miRNAs have recently emerged as important regulators of autophagy-related gene expression in cancer cells. Moreover, miRNA analysis studies have now identified a sea of aberrantly expressed miRNAs in ovarian cancer tissues that can affect autophagy in ovarian cancer cells. In addition, miRNAs in plasma and stromal cells in tumor patients can affect the expression of autophagy-related genes and can be used as biomarkers of ovarian cancer progression. This review focuses on the potential significance of miRNA-regulated autophagy in the diagnosis and treatment of ovarian cancer.

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Autophagy in the Lifetime of Plants: From Seed to Seed

Cited by 9 publications

References 119 publications

Autophagy and Symbiosis: Membranes, ER, and Speculations

Autophagy and Symbiosis: Membranes, ER, and Speculations

Vesicle trafficking in rice: too little is known

The emerging roles of miRNA-mediated autophagy in ovarian cancer

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