Autophagy impairment in Parkinson’s disease

Karabiyik, Cansu; Lee, Min Jae; Rubinsztein, David C.

doi:10.1042/ebc20170023

Cited by 127 publications

(96 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Defects in lysosomes are common denominators of neuronal diseases and found in, for example, Alzheimer's (Zare-Shahabadi et al, 2015), Parkinson's (Karabiyik et al, 2017) and Huntington's disease (Zhao et al, 2016). Lysosome-associated neurodegeneration is induced by a combination of mechanisms, most importantly, the accumulation of undegraded material (Jiang et al, 2014) and dysregulated signaling (Peng et al, 2012a).…”

Section: Neurological Defectsmentioning

confidence: 99%

CORVET, CHEVI and HOPS – multisubunit tethers of the endo-lysosomal system in health and disease

Beek

Jonker

Welle

et al. 2019

Journal of Cell Science

View full text Add to dashboard Cite

Multisubunit tethering complexes (MTCs) are multitasking hubs that form a link between membrane fusion, organelle motility and signaling. CORVET, CHEVI and HOPS are MTCs of the endo-lysosomal system. They regulate the major membrane flows required for endocytosis, lysosome biogenesis, autophagy and phagocytosis. In addition, individual subunits control complex-independent transport of specific cargoes and exert functions beyond tethering, such as attachment to microtubules and SNARE activation. Mutations in CHEVI subunits lead to arthrogryposis, renal dysfunction and cholestasis (ARC) syndrome, while defects in CORVET and, particularly, HOPS are associated with neurodegeneration, pigmentation disorders, liver malfunction and various forms of cancer. Diseases and phenotypes, however, vary per affected subunit and a concise overview of MTC protein function and associated human pathologies is currently lacking. Here, we provide an integrated overview on the cellular functions and pathological defects associated with CORVET, CHEVI or HOPS proteins, both with regard to their complexes and as individual subunits. The combination of these data provides novel insights into how mutations in endo-lysosomal proteins lead to human pathologies.

show abstract

Section: Neurological Defectsmentioning

confidence: 99%

CORVET, CHEVI and HOPS – multisubunit tethers of the endo-lysosomal system in health and disease

Beek

Jonker

Welle

et al. 2019

Journal of Cell Science

View full text Add to dashboard Cite

show abstract

“…In recent years, several pieces of evidence suggest that autophagy plays an important role in neurogenic disorders, such as HD, PD, Alzheimer's, and amyotrophic lateral sclerosis (Karabiyik, Lee, & Rubinsztein, 2017;Ouyang et al, 2018;Shi et al, 2012). However, other studies have shown that excessive autophagy could be related to neuronal death in cerebral ischemia (Fornai et al, 2008;Kabuta, Suzuki, & Wada, 2006;Shi et al, 2012).…”

Section: Ormond Et Al In a Study Used Stem Cells Alone Or In Combinamentioning

confidence: 99%

Stem Cell Therapy: Curcumin Does the Trick

Sharifi

Vahed

Ahmadian

et al. 2019

Phytotherapy Research

View full text Add to dashboard Cite

Curcumin is a dietary polyphenol and a bioactive phytochemical agent that possesses anti‐inflammatory, antioxidant, anticancer, and chemopreventive properties. Some of the predominant activities of stem cells include regeneration of identical cells and the ability to maintain the proliferation and multipotentiality. However, these cells could be stimulated to differentiate into specific cell types. Curcumin protects some stem cells from toxicity and can stimulate proliferation and differentiation of stem cells. In the present review, we summarize the antioxidant, stemness activity, antiaging, and neuroprotective as well as wound healing and regenerative effects of curcumin.

show abstract

“…Andrew Tee and Charlotte Johnston [11] provide an excellent primer on cancer autophagy and how mTOR-dependent signalling and regulation of autophagy in neoplastic disease offers potential vulnerabilities that provide tractable therapeutic targets that may work in certain disease contexts. The role of autophagy in Parkinson's disease is supported by evidence that Parkinson's disease-associated genes lead to autophagy impairment and so David Rubinzstein and colleagues [12] explain how this leads to disease pathology, but also more importantly, how our evolving understanding of brain autophagy could pave the way for exiting new therapies for the treatment of Parkinson's and possibly other neurodegenerative diseases. Cancer and neurodegenerative diseases are poignantly debilitating diseases, with the former associated with high disease recurrence risk and mortality, and the latter with progressive loss of cognitive abilities and control.…”

mentioning

confidence: 94%

Signalling mechanisms in autophagy: an introduction to the issue

Lane

Korolchuk

Murray

2017

Essays in Biochemistry

View full text Add to dashboard Cite

Essays in Biochemistry volume 61 (issue 6), entitled Signalling Mechanisms in Autophagy, covers a range of topics in autophagy signalling, touching on emerging new details on the mechanisms of autophagy regulation, novel aspects of selective autophagy and how autophagy functions in organelle homeostasis. It also looks at how autophagy research is leading to better understanding of human disease and plant biology that can be exploited for the benefit of society.The molecular understanding of autophagy has come a long way in a relatively short period of time, beginning with the seminal work of Yoshinori Ohsumi in the 1990s, for which he was awarded the 2016 Nobel Prize in Physiology or Medicine. This issue of Essays in Biochemistry contains a series of reviews of the current state-of-the-art in the field of autophagy signalling and its relationship to disease pathologies. While fantastic advances have been made in our collective knowledge of how autophagy is regulated in cell type-and tissue-specific manners, and how different autophagy cargoes are collected for disposal, these reviews also highlight that an enormous amount of work remains to be done. This can be achieved more rapidly by sharing ideas, knowledge, expertise and resources.In this respect, the formation of a large network of European autophagy researchers into the TRANSAUTOPHAGY network (http://cost-transautophagy.eu) has been a major step forward in synergising collective resources and expertise. The Action itself was the brainchild of Caty Casas Louzao, of the Universitat Autònoma de Barcelona, Spain, and she has been the champion of the efforts to establish a cohesive network of European autophagy researchers. Funded by a grant from the European Commission under its COST Association umbrella, TRANSAUTOPHAGY (CA15138) draws together autophagy researchers from across 31 European and associated countries representing academic and industrial research, and will run until the end of April 2020. Many of the authors of review articles in this collection are participants of this network and are supported in their networking activities and publications through funding from the TRANSAUTOPHAGY Action.

show abstract

Autophagy impairment in Parkinson’s disease

Cited by 127 publications

References 89 publications

CORVET, CHEVI and HOPS – multisubunit tethers of the endo-lysosomal system in health and disease

CORVET, CHEVI and HOPS – multisubunit tethers of the endo-lysosomal system in health and disease

Stem Cell Therapy: Curcumin Does the Trick

Signalling mechanisms in autophagy: an introduction to the issue

Contact Info

Product

Resources

About